Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001278086                                                           16    7355
NP_001229510                                                           16    7355
NP_061866                                                              16    7355
NP_001181876                                                           16    7355
NP_937887                                                              16    7355
NP_937884                                                              16    7355
NP_004944                                                              16    7355
NP_001181875                                                           16    7355
NP_937885                                                              16    7355
NP_886553                                                              16    7355
NP_001230133                                                           16    7355
NP_001135936                                                           16    7355
NP_057665                                                              16    7355
NP_848594                                                              16    7355
XP_005260790                                                           16    7355
XP_005260787                                                           16    7355
XP_005260789                                                           16    7355
XP_006723640                                                           16    7355
XP_006723639                                                           16    7355
XP_005260788                                                           16    7355
XP_006723638                                                           16    7355
XP_006723637                                                           16    7355
XP_006723636                                                           16    7355
XP_006719330                                                           16    7355
XP_005253911                                                           16    7355
XP_006719329                                                           16    7355
XP_006719328                                                           16    7355
NP_062551                                                              16    7355
NP_958441                                                              15    9605
NP_958439                                                              15    9605
NP_958440                                                              15    9605
NP_005219                                                              15    9605
XP_005268803                                                           15    9605
XP_005268802                                                           15    9605
XP_005268801                                                           15    9605
XP_005268800                                                           15    9605
XP_005268799                                                           15    9605
XP_006716155                                                           15    9605
NP_075051                                                              15    9605
NP_056090                                                              15    9605

>NP_001278086
          Length = 1559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 582 FIFASMQK 589



>NP_001229510
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 707 FMTMQKM 713



>NP_061866
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>NP_001181876
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 629 FIFASMQK 636



>NP_937887
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 535 FIFASMQK 542



>NP_937884
          Length = 1599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 622 FIFASMQK 629



>NP_004944
          Length = 1404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 426 FIFASMQK 433



>NP_001181875
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 629 FIFASMQK 636



>NP_937885
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 458 FIFASMQK 465



>NP_886553
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FLFMSLQK 8
           F+F S+QK
Sbjct: 622 FIFASMQK 629



>NP_001230133
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FLFMSLQKM 9
           F++++L+KM
Sbjct: 109 FIYLALRKM 117



>NP_001135936
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FLFMSLQKM 9
           F++++L+KM
Sbjct: 109 FIYLALRKM 117



>NP_057665
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   FLFMSLQKM 9
           F++++L+KM
Sbjct: 109 FIYLALRKM 117



>NP_848594
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+M+LQK+
Sbjct: 292 LYMNLQKL 299



>XP_005260790
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 452 FMTMQKM 458



>XP_005260787
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 624 FMTMQKM 630



>XP_005260789
          Length = 850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 613 FMTMQKM 619



>XP_006723640
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>XP_006723639
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>XP_005260788
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>XP_006723638
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>XP_006723637
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 658 FMTMQKM 664



>XP_006723636
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FMSLQKM 9
           FM++QKM
Sbjct: 707 FMTMQKM 713



>XP_006719330
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+M+LQK+
Sbjct: 292 LYMNLQKL 299



>XP_005253911
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+M+LQK+
Sbjct: 292 LYMNLQKL 299



>XP_006719329
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+M+LQK+
Sbjct: 292 LYMNLQKL 299



>XP_006719328
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+M+LQK+
Sbjct: 292 LYMNLQKL 299



>NP_062551
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LFMSLQKM 9
           L+MSL+K+
Sbjct: 109 LYMSLEKL 116



>NP_958441
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FMSLQKM 9
          F+SLQ+M
Sbjct: 48 FLSLQRM 54



>NP_958439
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FMSLQKM 9
          F+SLQ+M
Sbjct: 48 FLSLQRM 54



>NP_958440
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FMSLQKM 9
          F+SLQ+M
Sbjct: 48 FLSLQRM 54



>NP_005219
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  FMSLQKM 9
          F+SLQ+M
Sbjct: 48 FLSLQRM 54



>XP_005268803
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 460 LYMSMQK 466



>XP_005268802
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 461 LYMSMQK 467



>XP_005268801
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 272 LYMSMQK 278



>XP_005268800
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 273 LYMSMQK 279



>XP_005268799
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 461 LYMSMQK 467



>XP_006716155
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   FLFMSLQK 8
           F++++LQK
Sbjct: 472 FIYLALQK 479



>NP_075051
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   FLFMSLQK 8
           F++++LQK
Sbjct: 615 FIYLALQK 622



>NP_056090
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LFMSLQK 8
           L+MS+QK
Sbjct: 460 LYMSMQK 466



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.355    0.150    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,957
Number of extensions: 333
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.1 bits)
S2: 28 (15.4 bits)