Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     299
XP_006713721                                                           20     299
NP_002477                                                              17    2528
XP_005252054                                                           17    2528
NP_001265249                                                           16    7355
NP_001002755                                                           16    7355
NP_056515                                                              16    7355
NP_001094379                                                           16    7355
NP_004858                                                              16    7355
NP_001012417                                                           16    7355
NP_001165052                                                           16    7355
XP_006712051                                                           16    7355
NP_001942                                                              15    9605
NP_001077057                                                           15    9605
NP_001941                                                              15    9605
NP_001135780                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  FISVTQEAE 9
          F+SVTQEAE
Sbjct: 70 FVSVTQEAE 78
>XP_006713721
          Length = 1068

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  FISVTQEAE 9
          F+SVTQEAE
Sbjct: 70 FVSVTQEAE 78
>NP_002477
          Length = 790

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FISVTQEAE 9
           F+SVTQE +
Sbjct: 152 FVSVTQEED 160
>XP_005252054
          Length = 723

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  FISVTQEAE 9
          F+SVTQE +
Sbjct: 85 FVSVTQEED 93
>NP_001265249
          Length = 93

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SVTQEAE 9
          SVT+EAE
Sbjct: 84 SVTEEAE 90
>NP_001002755
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FISVTQEAE 9
           FI+VT+E E
Sbjct: 118 FITVTKENE 126
>NP_056515
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FISVTQEAE 9
           FI+VT+E E
Sbjct: 94  FITVTKENE 102
>NP_001094379
          Length = 112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SVTQEAE 9
           SVT+EAE
Sbjct: 103 SVTEEAE 109
>NP_004858
          Length = 263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FISVTQEAE 9
           F+ VT+EA+
Sbjct: 108 FLPVTEEAD 116
>NP_001012417
          Length = 152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SVTQEAE 9
           SVT+EAE
Sbjct: 143 SVTEEAE 149
>NP_001165052
          Length = 219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FISVTQEAE 9
          F+ VT+EA+
Sbjct: 64 FLPVTEEAD 72
>XP_006712051
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   FISVTQEAE 9
           FI+VT+E E
Sbjct: 94  FITVTKENE 102
>NP_001942
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FISVTQEAE 9
          F+S+ QEA+
Sbjct: 62 FVSLLQEAK 70
>NP_001077057
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FISVTQEAE 9
          F+S+ QEA+
Sbjct: 62 FVSLLQEAK 70
>NP_001941
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FISVTQEAE 9
          F+S+ QEA+
Sbjct: 29 FVSLLQEAK 37
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ISVTQEAE 9
           ISV+QE E
Sbjct: 629 ISVSQECE 636
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.121    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 378,043
Number of extensions: 393
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package