Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     509
NP_060785                                                              20     509
NP_361014                                                              20     509
NP_003621                                                              17    3301
XP_006710739                                                           17    3301
XP_005270979                                                           17    3301
NP_056972                                                              17    3301
NP_001243092                                                           16    5631
NP_001243095                                                           16    5631
NP_001157                                                              16    5631
NP_001750                                                              16    5631
NP_031382                                                              16    5631
XP_005253870                                                           16    5631
XP_005250289                                                           16    5631
NP_056171                                                              16    7355
NP_874365                                                              16    7355
NP_001165907                                                           16    7355
NP_000284                                                              16    7355
NP_002628                                                              16    7355
NP_001027005                                                           16    7355
NP_000283                                                              16    7355
NP_001116142                                                           16    7355
NP_001191102                                                           16    7355
NP_001364                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_733827                                                              16    7355
NP_001028750                                                           16    7355
NP_037389                                                              16    7355
XP_006724724                                                           16    7355
XP_005274607                                                           16    7355
XP_005274605                                                           16    7355
XP_006724560                                                           16    7355
XP_006724559                                                           16    7355
XP_005256041                                                           16    7355
XP_005256040                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
XP_006711798                                                           16    7355
NP_001254479                                                           16    7355
NP_000065                                                              15    9605
NP_598375                                                              15    9605
NP_056993                                                              15    9605
NP_001119580                                                           15    9605
NP_000330                                                              15    9605
NP_001119579                                                           15    9605
NP_694539                                                              15    9605
NP_001180404                                                           15    9605
NP_005151                                                              15    9605
NP_001129101                                                           15    9605
XP_006724221                                                           15    9605
XP_005256176                                                           15    9605
XP_005262773                                                           15    9605
XP_006714140                                                           15    9605
XP_005262771                                                           15    9605
XP_005262770                                                           15    9605
XP_005262769                                                           15    9605
XP_005262768                                                           15    9605
NP_065172                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FIQNLVTLE 9
           FI+NLVTLE
Sbjct: 538 FIRNLVTLE 546
>NP_060785
          Length = 627

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FIQNLVTLE 9
           FI+NLVTLE
Sbjct: 576 FIRNLVTLE 584
>NP_361014
          Length = 707

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FIQNLVTLE 9
           FI+NLVTLE
Sbjct: 656 FIRNLVTLE 664
>NP_003621
          Length = 373

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   FIQNLVTLE 9
           F+Q+L+T+E
Sbjct: 344 FVQDLLTME 352
>XP_006710739
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IQNLVTLE 9
           IQN++TLE
Sbjct: 138 IQNIMTLE 145
>XP_005270979
          Length = 728

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IQNLVTLE 9
           IQN++TLE
Sbjct: 138 IQNIMTLE 145
>NP_056972
          Length = 728

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IQNLVTLE 9
           IQN++TLE
Sbjct: 138 IQNIMTLE 145
>NP_001243092
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           FIQNLV+
Sbjct: 112 FIQNLVS 118
>NP_001243095
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  FIQNLVT 7
          FIQNLV+
Sbjct: 63 FIQNLVS 69
>NP_001157
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           FIQNLV+
Sbjct: 112 FIQNLVS 118
>NP_001750
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IQNLVTLE 9
          +QNL+T+E
Sbjct: 27 LQNLLTIE 34
>NP_031382
          Length = 1761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   FIQNLVTL 8
           +IQ+LVTL
Sbjct: 216 YIQDLVTL 223
>XP_005253870
          Length = 217

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IQNLVTLE 9
          +QNL+T+E
Sbjct: 27 LQNLLTIE 34
>XP_005250289
          Length = 1761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   FIQNLVTL 8
           +IQ+LVTL
Sbjct: 216 YIQDLVTL 223
>NP_056171
          Length = 1630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IQNLVTLE 9
           + NLVTLE
Sbjct: 150 LANLVTLE 157
>NP_874365
          Length = 1655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IQNLVTLE 9
           + NLVTLE
Sbjct: 150 LANLVTLE 157
>NP_001165907
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>NP_000284
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 201 FIQNLV 206
>NP_002628
          Length = 1223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>NP_001027005
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 194 FIQNLV 199
>NP_000283
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>NP_001116142
          Length = 1210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>NP_001191102
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 97  FIQNLV 102
>NP_001364
          Length = 4515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            FI+NL+ ++
Sbjct: 4118 FIENLIAMQ 4126
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            F++N+ TL+
Sbjct: 6588 FVENVATLQ 6596
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            F++N+ TL+
Sbjct: 5661 FVENVATLQ 5669
>NP_733827
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 97  FIQNLV 102
>NP_001028750
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 97  FIQNLV 102
>NP_037389
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 97  FIQNLV 102
>XP_006724724
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>XP_005274607
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>XP_005274605
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>XP_006724560
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>XP_006724559
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 164 FIQNLV 169
>XP_005256041
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 194 FIQNLV 199
>XP_005256040
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           FIQNLV
Sbjct: 201 FIQNLV 206
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            F++N+ TL+
Sbjct: 6589 FVENVATLQ 6597
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            F++N+ TL+
Sbjct: 6589 FVENVATLQ 6597
>XP_006711798
          Length = 4586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            FI+NL+ ++
Sbjct: 4189 FIENLIAMQ 4197
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    FIQNLVTLE 9
            F++N+ TL+
Sbjct: 6905 FVENVATLQ 6913
>NP_000065
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLVTLE 9
           NLVTLE
Sbjct: 151 NLVTLE 156
>NP_598375
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 963 YIQNLLT 969
>NP_056993
          Length = 2371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NLVTLE 9
           NLVTLE
Sbjct: 884 NLVTLE 889
>NP_001119580
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           F+QNLV
Sbjct: 325 FVQNLV 330
>NP_000330
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           F+QNLV
Sbjct: 325 FVQNLV 330
>NP_001119579
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           F+QNLV
Sbjct: 324 FVQNLV 329
>NP_694539
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           F+Q+LVT
Sbjct: 262 FVQDLVT 268
>NP_001180404
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           F+Q+LVT
Sbjct: 262 FVQDLVT 268
>NP_005151
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QNLVTLE 9
           QNL+T+E
Sbjct: 598 QNLLTME 604
>NP_001129101
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           F+Q+LVT
Sbjct: 262 FVQDLVT 268
>XP_006724221
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QNLVTLE 9
           QNL+T+E
Sbjct: 485 QNLLTME 491
>XP_005256176
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FIQNLV 6
           F+QNLV
Sbjct: 324 FVQNLV 329
>XP_005262773
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 419 YIQNLLT 425
>XP_006714140
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 591 YIQNLLT 597
>XP_005262771
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 857 YIQNLLT 863
>XP_005262770
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 857 YIQNLLT 863
>XP_005262769
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 896 YIQNLLT 902
>XP_005262768
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   FIQNLVT 7
           +IQNL+T
Sbjct: 926 YIQNLLT 932
>NP_065172
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QNLVTLE 9
          +N+VTLE
Sbjct: 78 ENIVTLE 84
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.146    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 359,438
Number of extensions: 648
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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