Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              18    1135
NP_002871                                                              18    1135
XP_005250103                                                           18    1135
XP_005250102                                                           18    1135
XP_005265416                                                           18    1135
XP_005265415                                                           18    1135
XP_005265414                                                           18    1135
XP_005265412                                                           18    1135
NP_001243125                                                           17    2528
NP_001645                                                              17    2528
XP_006724592                                                           17    2528
NP_000523                                                              17    3301
NP_001032671                                                           17    3301
NP_001171485                                                           17    3301
NP_001265557                                                           17    3301
NP_001265555                                                           17    3301
NP_001265554                                                           17    3301
NP_001265556                                                           17    3301
NP_057736                                                              17    3301
XP_005247565                                                           17    3301
NP_001013725                                                           17    4312
XP_005254450                                                           17    4312
XP_005254449                                                           17    4312
NP_006741                                                              16    5631
NP_001623                                                              16    7355
XP_005246496                                                           16    7355
NP_072088                                                              16    7355
NP_112603                                                              16    7355
NP_000247                                                              15    9605
NP_001268666                                                           15    9605
NP_004444                                                              15    9605
NP_001268667                                                           15    9605
NP_005902                                                              15    9605
NP_783322                                                              15    9605
NP_783324                                                              15    9605
NP_071901                                                              15    9605
NP_783323                                                              15    9605
NP_919289                                                              15    9605
NP_000420                                                              15    9605
XP_006726466                                                           15    9605
XP_006719291                                                           15    9605
XP_006719290                                                           15    9605
XP_006719289                                                           15    9605
XP_006718301                                                           15    9605
XP_005269900                                                           15    9605
XP_005269899                                                           15    9605
XP_006716827                                                           15    9605
XP_005251508                                                           15    9605
XP_005251507                                                           15    9605
XP_006712969                                                           15    9605
XP_005275995                                                           15    9605
NP_110382                                                              15    9605
>NP_004324
          Length = 766

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 595 FGLATVKSR 603
>NP_002871
          Length = 648

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 487 FGLATVKSR 495
>XP_005250103
          Length = 758

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 595 FGLATVKSR 603
>XP_005250102
          Length = 767

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 595 FGLATVKSR 603
>XP_005265416
          Length = 534

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 373 FGLATVKSR 381
>XP_005265415
          Length = 567

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 406 FGLATVKSR 414
>XP_005265414
          Length = 615

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 454 FGLATVKSR 462
>XP_005265412
          Length = 648

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT KSR
Sbjct: 487 FGLATVKSR 495
>NP_001243125
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT K+R
Sbjct: 451 FGLATVKTR 459
>NP_001645
          Length = 606

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT K+R
Sbjct: 448 FGLATVKTR 456
>XP_006724592
          Length = 611

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FGLAT K+R
Sbjct: 453 FGLATVKTR 461
>NP_000523
          Length = 539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FG+A DK++
Sbjct: 93  FGMAADKNK 101
>NP_001032671
          Length = 330

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GLATDKSR 9
           GLATD+ R
Sbjct: 305 GLATDRKR 312
>NP_001171485
          Length = 559

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FG+A DK++
Sbjct: 93  FGMAADKNK 101
>NP_001265557
          Length = 687

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG A+DK R
Sbjct: 604 FGTASDKER 612
>NP_001265555
          Length = 564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG A+DK R
Sbjct: 481 FGTASDKER 489
>NP_001265554
          Length = 836

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG A+DK R
Sbjct: 753 FGTASDKER 761
>NP_001265556
          Length = 564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG A+DK R
Sbjct: 481 FGTASDKER 489
>NP_057736
          Length = 848

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG A+DK R
Sbjct: 765 FGTASDKER 773
>XP_005247565
          Length = 447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   FGLATDKSR 9
           FG+A DK++
Sbjct: 93  FGMAADKNK 101
>NP_001013725
          Length = 1649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGLATD
Sbjct: 867 FGLATD 872
>XP_005254450
          Length = 1505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGLATD
Sbjct: 867 FGLATD 872
>XP_005254449
          Length = 1626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGLATD
Sbjct: 867 FGLATD 872
>NP_006741
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GLATDKSR 9
           GLA D+SR
Sbjct: 148 GLAADQSR 155
>NP_001623
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FGLA  K+R
Sbjct: 397 FGLAPGKAR 405
>XP_005246496
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FGLA  K+R
Sbjct: 412 FGLAPGKAR 420
>NP_072088
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LATDKSR 9
           LA+DKSR
Sbjct: 200 LASDKSR 206
>NP_112603
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FGLA  K+R
Sbjct: 394 FGLAPGKAR 402
>NP_000247
          Length = 1274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FGLATDKSR 9
          +GLAT+ +R
Sbjct: 55 YGLATEGTR 63
>NP_001268666
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG+ T+K R
Sbjct: 100 FGILTEKYR 108
>NP_004444
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGLATDKSR 9
           FG+ T+K R
Sbjct: 147 FGILTEKYR 155
>NP_001268667
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  FGLATDKSR 9
          FG+ T+K R
Sbjct: 86 FGILTEKYR 94
>NP_005902
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FGLATDKS 8
           FG ATD++
Sbjct: 139 FGYATDET 146
>NP_783322
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 151 FGLSTD 156
>NP_783324
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 151 FGLSTD 156
>NP_071901
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 135 FGLSTD 140
>NP_783323
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 135 FGLSTD 140
>NP_919289
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    FGLATD 6
            FGL+TD
Sbjct: 1235 FGLSTD 1240
>NP_000420
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FGLATDKS 8
           FG ATD++
Sbjct: 139 FGYATDET 146
>XP_006726466
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLATDKS 8
           GLA DKS
Sbjct: 228 GLAQDKS 234
>XP_006719291
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 185 FGLSTD 190
>XP_006719290
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 185 FGLSTD 190
>XP_006719289
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 185 FGLSTD 190
>XP_006718301
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  FGLATDKSR 9
          +GLAT+ +R
Sbjct: 55 YGLATEGTR 63
>XP_005269900
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FGLATDKS 8
           FG ATD++
Sbjct: 98  FGYATDET 105
>XP_005269899
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FGLATDKS 8
           FG ATD++
Sbjct: 139 FGYATDET 146
>XP_006716827
          Length = 910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 777 FGLSTD 782
>XP_005251508
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 874 FGLSTD 879
>XP_005251507
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FGLATD 6
           FGL+TD
Sbjct: 946 FGLSTD 951
>XP_006712969
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLATDKS 8
           GLA DKS
Sbjct: 228 GLAQDKS 234
>XP_005275995
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLATDKS 8
           GLA DKS
Sbjct: 228 GLAQDKS 234
>NP_110382
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LATDKS 8
           LATDKS
Sbjct: 275 LATDKS 280
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.134    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,326
Number of extensions: 595
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package