Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              18    1135
XP_006714104                                                           18    1135
XP_005265800                                                           18    1135
XP_006714103                                                           18    1135
XP_006714102                                                           18    1135
NP_006816                                                              17    2528
NP_000386                                                              17    4312
XP_005261397                                                           17    4312
XP_006710230                                                           16    5631
NP_001265546                                                           16    7355
NP_001265545                                                           16    7355
NP_001138619                                                           16    7355
NP_005934                                                              16    7355
NP_001138618                                                           16    7355
NP_001138620                                                           16    7355
NP_004327                                                              16    7355
NP_001243228                                                           16    7355
NP_004373                                                              16    7355
NP_775832                                                              16    7355
NP_001068566                                                           16    7355
NP_001243084                                                           15    9605
NP_003493                                                              15    9605
NP_851393                                                              15    9605
NP_055740                                                              15    9605
NP_075067                                                              15    9605
XP_005255666                                                           15    9605
XP_005255665                                                           15    9605
XP_005255664                                                           15    9605
XP_005268786                                                           15    9605
XP_005268785                                                           15    9605
XP_005268784                                                           15    9605
XP_005268782                                                           15    9605
XP_005268781                                                           15    9605
XP_006719352                                                           15    9605
XP_005268779                                                           15    9605
XP_006719351                                                           15    9605
XP_006719350                                                           15    9605
XP_006719349                                                           15    9605
XP_006719348                                                           15    9605
XP_006719347                                                           15    9605
XP_005268772                                                           15    9605
XP_006719346                                                           15    9605
XP_006719345                                                           15    9605
XP_006719344                                                           15    9605
XP_006719343                                                           15    9605
XP_006719342                                                           15    9605
XP_006719341                                                           15    9605
XP_005268768                                                           15    9605
XP_006719340                                                           15    9605
>NP_006197
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FGESEVSRQ 9
          FGESEVS Q
Sbjct: 50 FGESEVSWQ 58
>XP_006714104
          Length = 832

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FGESEVSRQ 9
          FGESEVS Q
Sbjct: 75 FGESEVSWQ 83
>XP_005265800
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FGESEVSRQ 9
          FGESEVS Q
Sbjct: 50 FGESEVSWQ 58
>XP_006714103
          Length = 1111

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FGESEVSRQ 9
          FGESEVS Q
Sbjct: 72 FGESEVSWQ 80
>XP_006714102
          Length = 1114

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  FGESEVSRQ 9
          FGESEVS Q
Sbjct: 75 FGESEVSWQ 83
>NP_006816
          Length = 602

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   GESEVSR 8
           GESEVSR
Sbjct: 193 GESEVSR 199
>NP_000386
          Length = 897

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   FGESEVS 7
           FG+SEVS
Sbjct: 529 FGDSEVS 535
>XP_005261397
          Length = 903

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   FGESEVS 7
           FG+SEVS
Sbjct: 535 FGDSEVS 541
>XP_006710230
          Length = 332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   FGESEVS 7
           FGE EVS
Sbjct: 178 FGEKEVS 184
>NP_001265546
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   FGESEVSR 8
           FGE  VSR
Sbjct: 553 FGERSVSR 560
>NP_001265545
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   FGESEVSR 8
           FGE  VSR
Sbjct: 533 FGERSVSR 540
>NP_001138619
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE EVSR
Sbjct: 295 GEDEVSR 301
>NP_005934
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   FGESEVS 7
           FG SEVS
Sbjct: 331 FGNSEVS 337
>NP_001138618
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE EVSR
Sbjct: 364 GEDEVSR 370
>NP_001138620
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE EVSR
Sbjct: 335 GEDEVSR 341
>NP_004327
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   FGESEVSR 8
           FGE  VSR
Sbjct: 553 FGERSVSR 560
>NP_001243228
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE EVSR
Sbjct: 160 GEDEVSR 166
>NP_004373
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE EVSR
Sbjct: 335 GEDEVSR 341
>NP_775832
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  ESEVSRQ 9
          E+EVSRQ
Sbjct: 61 ENEVSRQ 67
>NP_001068566
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   FGESEVS 7
           FG SEVS
Sbjct: 331 FGNSEVS 337
>NP_001243084
          Length = 2290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GESEVSRQ 9
            GE E+SR+
Sbjct: 1883 GEDELSRE 1890
>NP_003493
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE E+SR
Sbjct: 639 GEKEISR 645
>NP_851393
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE E+SR
Sbjct: 639 GEKEISR 645
>NP_055740
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 442 FGQMSLSRQ 450
>NP_075067
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+ E +RQ
Sbjct: 193 FGKGECARQ 201
>XP_005255666
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE E+SR
Sbjct: 639 GEKEISR 645
>XP_005255665
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE E+SR
Sbjct: 688 GEKEISR 694
>XP_005255664
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GESEVSR 8
           GE E+SR
Sbjct: 688 GEKEISR 694
>XP_005268786
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 137 FGQMSLSRQ 145
>XP_005268785
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 169 FGQMSLSRQ 177
>XP_005268784
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 203 FGQMSLSRQ 211
>XP_005268782
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 442 FGQMSLSRQ 450
>XP_005268781
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 455 FGQMSLSRQ 463
>XP_006719352
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 490 FGQMSLSRQ 498
>XP_005268779
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 500 FGQMSLSRQ 508
>XP_006719351
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 516 FGQMSLSRQ 524
>XP_006719350
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 516 FGQMSLSRQ 524
>XP_006719349
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 516 FGQMSLSRQ 524
>XP_006719348
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 522 FGQMSLSRQ 530
>XP_006719347
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 524 FGQMSLSRQ 532
>XP_005268772
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 534 FGQMSLSRQ 542
>XP_006719346
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 540 FGQMSLSRQ 548
>XP_006719345
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 542 FGQMSLSRQ 550
>XP_006719344
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 554 FGQMSLSRQ 562
>XP_006719343
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 556 FGQMSLSRQ 564
>XP_006719342
          Length = 1090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 556 FGQMSLSRQ 564
>XP_006719341
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 565 FGQMSLSRQ 573
>XP_005268768
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 566 FGQMSLSRQ 574
>XP_006719340
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FGESEVSRQ 9
           FG+  +SRQ
Sbjct: 574 FGQMSLSRQ 582
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.123    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,062
Number of extensions: 641
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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