Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              20     299
XP_005269721                                                           20     299
NP_055855                                                              17    2528
XP_006712426                                                           17    2528
XP_006712425                                                           17    2528
XP_006712424                                                           17    2528
NP_001273718                                                           17    4312
NP_001748                                                              17    4312
NP_001274268                                                           16    5631
NP_001073138                                                           16    5631
NP_112187                                                              16    5631
NP_001274266                                                           16    5631
NP_001274267                                                           16    5631
NP_001009183                                                           16    5631
NP_001009182                                                           16    5631
NP_003607                                                              16    5631
XP_006724143                                                           16    5631
NP_001275668                                                           16    7355
NP_004399                                                              16    7355
NP_001275667                                                           16    7355
NP_001005336                                                           16    7355
NP_001275666                                                           16    7355
NP_001275938                                                           16    7355
NP_060512                                                              16    7355
XP_006722030                                                           16    7355
XP_005258052                                                           16    7355
XP_005255224                                                           16    7355
XP_006721087                                                           16    7355
XP_006720436                                                           16    7355
XP_005254183                                                           16    7355
XP_006717057                                                           16    7355
XP_006717056                                                           16    7355
XP_005251826                                                           16    7355
XP_005251825                                                           16    7355
XP_005251821                                                           16    7355
XP_005251820                                                           16    7355
XP_006717055                                                           16    7355
XP_005249650                                                           16    7355
XP_005249649                                                           16    7355
NP_031368                                                              16    7355
NP_777584                                                              16    7355
NP_006374                                                              16    7355
NP_001269645                                                           15    9605
NP_036579                                                              15    9605
NP_001269646                                                           15    9605
NP_001269647                                                           15    9605
NP_653297                                                              15    9605
NP_775970                                                              15    9605
NP_056150                                                              15    9605
NP_060018                                                              15    9605
NP_001127894                                                           15    9605
NP_919269                                                              15    9605
NP_001182719                                                           15    9605
XP_006726617                                                           15    9605
XP_006720409                                                           15    9605
XP_005269093                                                           15    9605
XP_006719370                                                           15    9605
XP_006719369                                                           15    9605
XP_006719368                                                           15    9605
XP_005250173                                                           15    9605
XP_005247648                                                           15    9605
XP_005247647                                                           15    9605
XP_005247646                                                           15    9605
XP_005247645                                                           15    9605
XP_005264966                                                           15    9605
XP_006711224                                                           15    9605
XP_006711223                                                           15    9605
XP_006711222                                                           15    9605
XP_006711221                                                           15    9605
XP_006711220                                                           15    9605
XP_006710039                                                           15    9605
NP_064629                                                              15    9605
>NP_036462
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FFGKRDITS 9
           FFGKRDI S
Sbjct: 587 FFGKRDIRS 595
>XP_005269721
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FFGKRDITS 9
           FFGKRDI S
Sbjct: 587 FFGKRDIRS 595
>NP_055855
          Length = 2098

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    FFGKRDIT 8
            F+GK D+T
Sbjct: 1246 FYGKNDLT 1253
>XP_006712426
          Length = 1237

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           F+GK D+T
Sbjct: 552 FYGKNDLT 559
>XP_006712425
          Length = 1349

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           F+GK D+T
Sbjct: 552 FYGKNDLT 559
>XP_006712424
          Length = 1376

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           F+GK D+T
Sbjct: 552 FYGKNDLT 559
>NP_001273718
          Length = 173

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FFGKRDI 7
           FFG RD+
Sbjct: 115 FFGTRDV 121
>NP_001748
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   FFGKRDI 7
           FFG RD+
Sbjct: 115 FFGTRDV 121
>NP_001274268
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FFGKRDIT 8
          F GK+D+T
Sbjct: 91 FEGKKDVT 98
>NP_001073138
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FFGKRDIT 8
          F GK+D+T
Sbjct: 91 FEGKKDVT 98
>NP_112187
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FFGKRDIT 8
          F GK+D+T
Sbjct: 91 FEGKKDVT 98
>NP_001274266
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FFGKRDIT 8
          F GK+D+T
Sbjct: 91 FEGKKDVT 98
>NP_001274267
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  FFGKRDIT 8
          F GK+D+T
Sbjct: 91 FEGKKDVT 98
>NP_001009183
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           +FG+RD T
Sbjct: 201 WFGERDFT 208
>NP_001009182
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           +FG+RD T
Sbjct: 186 WFGERDFT 193
>NP_003607
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FFGKRDIT 8
           +FG+RD T
Sbjct: 201 WFGERDFT 208
>XP_006724143
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FGKRDI 7
          FGKRD+
Sbjct: 27 FGKRDL 32
>NP_001275668
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>NP_004399
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>NP_001275667
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>NP_001005336
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>NP_001275666
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>NP_001275938
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRDITS 9
           KRDITS
Sbjct: 128 KRDITS 133
>NP_060512
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRDITS 9
           KRDITS
Sbjct: 128 KRDITS 133
>XP_006722030
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRDITS 9
           KRDITS
Sbjct: 128 KRDITS 133
>XP_005258052
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KRDITS 9
           KRDITS
Sbjct: 128 KRDITS 133
>XP_005255224
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FGKRDIT 8
           FGK DIT
Sbjct: 98  FGKVDIT 104
>XP_006721087
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FGKRDIT 8
           FGK DIT
Sbjct: 98  FGKVDIT 104
>XP_006720436
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FFGKRDI 7
          FF K+DI
Sbjct: 21 FFNKKDI 27
>XP_005254183
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FFGKRDI 7
          FF K+DI
Sbjct: 21 FFNKKDI 27
>XP_006717057
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_006717056
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_005251826
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_005251825
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_005251821
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_005251820
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_006717055
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GKRDITS 9
           GK+DIT+
Sbjct: 244 GKKDITA 250
>XP_005249650
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FGK ++TS
Sbjct: 192 FGKPEVTS 199
>XP_005249649
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FGK ++TS
Sbjct: 315 FGKPEVTS 322
>NP_031368
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FGK ++TS
Sbjct: 290 FGKPEVTS 297
>NP_777584
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FGKRDIT 8
           FGK DIT
Sbjct: 98  FGKVDIT 104
>NP_006374
          Length = 187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  FFGKRDI 7
          FF K+DI
Sbjct: 21 FFNKKDI 27
>NP_001269645
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           +G RD+T+
Sbjct: 371 YGNRDLTT 378
>NP_036579
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           +G RD+T+
Sbjct: 371 YGNRDLTT 378
>NP_001269646
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           +G RD+T+
Sbjct: 371 YGNRDLTT 378
>NP_001269647
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           +G RD+T+
Sbjct: 313 YGNRDLTT 320
>NP_653297
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 494 FFNEKDILS 502
>NP_775970
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FFGKRDIT 8
           FF K D+T
Sbjct: 176 FFSKLDLT 183
>NP_056150
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FG +D+T+
Sbjct: 751 FGTKDVTT 758
>NP_060018
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>NP_001127894
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>NP_919269
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    GKRDIT 8
            GK+DIT
Sbjct: 1720 GKKDIT 1725
>NP_001182719
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KRDITS 9
           KRD+TS
Sbjct: 146 KRDVTS 151
>XP_006726617
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GKRDIT 8
           GK+DIT
Sbjct: 799 GKKDIT 804
>XP_006720409
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GKRDIT 8
           GK+DIT
Sbjct: 799 GKKDIT 804
>XP_005269093
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FGKRDIT 8
           FGK D+T
Sbjct: 186 FGKVDVT 192
>XP_006719370
          Length = 2076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FG +D+T+
Sbjct: 617 FGTKDVTT 624
>XP_006719369
          Length = 2200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FG +D+T+
Sbjct: 741 FGTKDVTT 748
>XP_006719368
          Length = 2209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           FG +D+T+
Sbjct: 751 FGTKDVTT 758
>XP_005250173
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FGKRDITS 9
           +G RD+T+
Sbjct: 371 YGNRDLTT 378
>XP_005247648
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>XP_005247647
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>XP_005247646
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>XP_005247645
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  FFGKRD 6
          FF KRD
Sbjct: 12 FFAKRD 17
>XP_005264966
          Length = 1843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    GKRDIT 8
            GK+DIT
Sbjct: 1720 GKKDIT 1725
>XP_006711224
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 494 FFNEKDILS 502
>XP_006711223
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 494 FFNEKDILS 502
>XP_006711222
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 452 FFNEKDILS 460
>XP_006711221
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 494 FFNEKDILS 502
>XP_006711220
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FFGKRDITS 9
           FF ++DI S
Sbjct: 494 FFNEKDILS 502
>XP_006710039
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GKRDIT 8
           GK+DIT
Sbjct: 695 GKKDIT 700
>NP_064629
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FGKRDIT 8
           FGK D+T
Sbjct: 186 FGKVDVT 192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.150    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 549,639
Number of extensions: 814
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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