Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              20     299
NP_001120972                                                           20     299
XP_006716054                                                           20     299
XP_006716053                                                           20     299
XP_006716052                                                           20     299
XP_006716051                                                           20     299
NP_000531                                                              18    1935
NP_001036188                                                           18    1935
XP_006723382                                                           18    1935
XP_006723381                                                           18    1935
XP_006723380                                                           18    1935
NP_776249                                                              17    4312
NP_001188386                                                           17    4312
NP_938207                                                              17    4312
NP_112562                                                              17    4312
NP_001269869                                                           17    4312
NP_001034934                                                           17    4312
XP_006722041                                                           17    4312
XP_005257576                                                           17    4312
XP_006722040                                                           17    4312
XP_006722039                                                           17    4312
XP_005257575                                                           17    4312
XP_005267408                                                           17    4312
XP_005246372                                                           17    4312
NP_002401                                                              16    5631
XP_006719941                                                           16    5631
XP_006719940                                                           16    5631
XP_005263727                                                           16    5631
XP_005263726                                                           16    5631
XP_006712598                                                           16    5631
XP_005263725                                                           16    5631
XP_006712597                                                           16    5631
XP_005263723                                                           16    5631
NP_113619                                                              16    5631
NP_066408                                                              16    7355
NP_003504                                                              16    7355
NP_002096                                                              16    7355
NP_005752                                                              16    7355
NP_542163                                                              16    7355
NP_061883                                                              16    7355
NP_778235                                                              16    7355
NP_003508                                                              16    7355
NP_003500                                                              16    7355
NP_254280                                                              16    7355
NP_066390                                                              16    7355
NP_003501                                                              16    7355
NP_003505                                                              16    7355
NP_003502                                                              16    7355
NP_003503                                                              16    7355
NP_734466                                                              16    7355
NP_001035807                                                           16    7355
NP_066409                                                              16    7355
NP_003507                                                              16    7355
XP_006719249                                                           16    7355
NP_079232                                                              16    7355
NP_808760                                                              16    7355
NP_066544                                                              16    7355
NP_001275938                                                           15    9605
NP_001035362                                                           15    9605
NP_919226                                                              15    9605
NP_056073                                                              15    9605
NP_060512                                                              15    9605
NP_443098                                                              15    9605
XP_006722030                                                           15    9605
XP_005258052                                                           15    9605
XP_005273894                                                           15    9605
XP_006717082                                                           15    9605
XP_006717081                                                           15    9605
NP_878253                                                              15    9605
>NP_000236
          Length = 1390

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 596 FDLKKTRVL 604
>NP_001120972
          Length = 1408

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 596 FDLKKTRVL 604
>XP_006716054
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 166 FDLKKTRVL 174
>XP_006716053
          Length = 960

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 166 FDLKKTRVL 174
>XP_006716052
          Length = 1409

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 615 FDLKKTRVL 623
>XP_006716051
          Length = 1427

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   FDLKKTRVV 9
           FDLKKTRV+
Sbjct: 615 FDLKKTRVL 623
>NP_000531
          Length = 5038

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    FDLKKTRVV 9
            FDL K RVV
Sbjct: 1463 FDLSKVRVV 1471
>NP_001036188
          Length = 5033

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    FDLKKTRVV 9
            FDL K RVV
Sbjct: 1463 FDLSKVRVV 1471
>XP_006723382
          Length = 5027

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    FDLKKTRVV 9
            FDL K RVV
Sbjct: 1463 FDLSKVRVV 1471
>XP_006723381
          Length = 5031

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    FDLKKTRVV 9
            FDL K RVV
Sbjct: 1462 FDLSKVRVV 1470
>XP_006723380
          Length = 5032

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    FDLKKTRVV 9
            FDL K RVV
Sbjct: 1463 FDLSKVRVV 1471
>NP_776249
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FDLKKT 6
           FDLKKT
Sbjct: 317 FDLKKT 322
>NP_001188386
          Length = 1497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 318 DLEKTRLV 325
>NP_938207
          Length = 1491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 312 DLEKTRLV 319
>NP_112562
          Length = 1451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 312 DLEKTRLV 319
>NP_001269869
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DLKKTRV 8
           DL+KTRV
Sbjct: 321 DLRKTRV 327
>NP_001034934
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DLKKTRV 8
           DL+KTRV
Sbjct: 321 DLRKTRV 327
>XP_006722041
          Length = 1445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 315 DLEKTRLV 322
>XP_005257576
          Length = 1454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 315 DLEKTRLV 322
>XP_006722040
          Length = 1466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 315 DLEKTRLV 322
>XP_006722039
          Length = 1491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 312 DLEKTRLV 319
>XP_005257575
          Length = 1494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DLKKTRVV 9
           DL+KTR+V
Sbjct: 315 DLEKTRLV 322
>XP_005267408
          Length = 414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   FDLKKT 6
           FDLKKT
Sbjct: 317 FDLKKT 322
>XP_005246372
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DLKKTRV 8
           DL+KTRV
Sbjct: 223 DLRKTRV 229
>NP_002401
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_006719941
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           DLKKTR
Sbjct: 509 DLKKTR 514
>XP_006719940
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           DLKKTR
Sbjct: 638 DLKKTR 643
>XP_005263727
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_005263726
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_006712598
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_005263725
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_006712597
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>XP_005263723
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  FDLKKTRVV 9
          +DLKKT  V
Sbjct: 80 YDLKKTLAV 88
>NP_113619
          Length = 828

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           DLKKTR
Sbjct: 638 DLKKTR 643
>NP_066408
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003504
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_002096
          Length = 143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_005752
          Length = 1568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    FDLKKT 6
            FD+KKT
Sbjct: 1430 FDIKKT 1435
>NP_542163
          Length = 128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_061883
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DLKKTRVV 9
           D+KKTR +
Sbjct: 393 DIKKTRKI 400
>NP_778235
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003508
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003500
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_254280
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_066390
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003501
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003505
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003502
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003503
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_734466
          Length = 131

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_001035807
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_066409
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_003507
          Length = 130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>XP_006719249
          Length = 1555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    FDLKKT 6
            FD+KKT
Sbjct: 1417 FDIKKT 1422
>NP_079232
          Length = 643

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKKTRVV 9
           LKKTRV+
Sbjct: 125 LKKTRVM 131
>NP_808760
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_066544
          Length = 128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DLKKTRVV 9
          D KKTR++
Sbjct: 73 DNKKTRII 80
>NP_001275938
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           D+KKTR
Sbjct: 148 DMKKTR 153
>NP_001035362
          Length = 1762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FDLKKTRVV 9
           +DL+  RVV
Sbjct: 325 YDLRSNRVV 333
>NP_919226
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   FDLKKTRV 8
           FD K T+V
Sbjct: 462 FDFKSTKV 469
>NP_056073
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKKTRV 8
           LKKTRV
Sbjct: 779 LKKTRV 784
>NP_060512
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           D+KKTR
Sbjct: 148 DMKKTR 153
>NP_443098
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   FDLKKTRVV 9
           +DL+  RVV
Sbjct: 325 YDLRSNRVV 333
>XP_006722030
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           D+KKTR
Sbjct: 148 DMKKTR 153
>XP_005258052
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLKKTR 7
           D+KKTR
Sbjct: 148 DMKKTR 153
>XP_005273894
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FDLKKT 6
           FDLK+T
Sbjct: 247 FDLKRT 252
>XP_006717082
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKKTRV 8
           LKKTRV
Sbjct: 711 LKKTRV 716
>XP_006717081
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKKTRV 8
           LKKTRV
Sbjct: 769 LKKTRV 774
>NP_878253
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   FDLKKT 6
           FDLK+T
Sbjct: 247 FDLKRT 252
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.146    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 434,320
Number of extensions: 625
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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