Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     390
XP_006713721                                                           20     390
NP_775821                                                              17    3301
XP_005251455                                                           17    3301
XP_005251456                                                           17    3301
XP_005251454                                                           17    3301
NP_001243754                                                           17    4312
NP_001243752                                                           17    4312
NP_001123991                                                           17    4312
NP_001229771                                                           17    4312
NP_001229772                                                           17    4312
NP_001123992                                                           17    4312
NP_009083                                                              17    4312
NP_001229770                                                           17    4312
NP_001243753                                                           17    4312
XP_006718369                                                           17    4312
NP_056344                                                              16    5631
NP_002010                                                              16    5631
NP_001153392                                                           16    5631
NP_001153503                                                           16    5631
NP_001153502                                                           16    5631
XP_006715519                                                           16    5631
NP_036342                                                              16    7355
NP_001093149                                                           16    7355
NP_065433                                                              16    7355
NP_689707                                                              16    7355
NP_001153101                                                           16    7355
NP_003636                                                              16    7355
NP_997253                                                              16    7355
NP_001137159                                                           16    7355
XP_005251870                                                           16    7355
NP_001003750                                                           16    7355
NP_073753                                                              15    9605
NP_064541                                                              15    9605
NP_689854                                                              15    9605
NP_683692                                                              15    9605
NP_114110                                                              15    9605
NP_060700                                                              15    9605
NP_006832                                                              15    9605
XP_005261216                                                           15    9605
XP_006719336                                                           15    9605
XP_006719335                                                           15    9605
XP_005274406                                                           15    9605
XP_006715822                                                           15    9605
XP_005249870                                                           15    9605
XP_005249869                                                           15    9605
XP_005248208                                                           15    9605
XP_005248207                                                           15    9605
XP_006714021                                                           15    9605
XP_005265461                                                           15    9605
XP_006713017                                                           15    9605
NP_703148                                                              15    9605
>NP_006209
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FAIGMLVCE 9
           FAIGM VCE
Sbjct: 119 FAIGMPVCE 127
>XP_006713721
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   FAIGMLVCE 9
           FAIGM VCE
Sbjct: 119 FAIGMPVCE 127
>NP_775821
          Length = 1326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IGMLVC
Sbjct: 835 IGMLVC 840
>XP_005251455
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IGMLVC
Sbjct: 843 IGMLVC 848
>XP_005251456
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IGMLVC
Sbjct: 843 IGMLVC 848
>XP_005251454
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IGMLVC
Sbjct: 843 IGMLVC 848
>NP_001243754
          Length = 561

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>NP_001243752
          Length = 90

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>NP_001123991
          Length = 606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 41 FSVGLTVCK 49
>NP_001229771
          Length = 584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>NP_001229772
          Length = 561

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>NP_001123992
          Length = 629

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 41 FSVGLTVCK 49
>NP_009083
          Length = 557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 41 FSVGLTVCK 49
>NP_001229770
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>NP_001243753
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 45 FSVGLTVCK 53
>XP_006718369
          Length = 572

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  FAIGMLVCE 9
          F++G+ VC+
Sbjct: 56 FSVGLTVCK 64
>NP_056344
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FAIGMLVC 8
           F+I +LVC
Sbjct: 593 FSINLLVC 600
>NP_002010
          Length = 1338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IGMLVCE 9
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001153392
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IGMLVCE 9
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001153503
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IGMLVCE 9
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001153502
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IGMLVCE 9
           IG+L CE
Sbjct: 202 IGLLTCE 208
>XP_006715519
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   FAIGMLVC 8
           F+I +LVC
Sbjct: 583 FSINLLVC 590
>NP_036342
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AIGMLVC 8
           A+G+L+C
Sbjct: 94  AVGLLMC 100
>NP_001093149
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AIGMLVC 8
           A+G+L+C
Sbjct: 94  AVGLLMC 100
>NP_065433
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  FAIGMLVC 8
          FAI +LVC
Sbjct: 90 FAIFILVC 97
>NP_689707
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IG+LVC
Sbjct: 558 IGLLVC 563
>NP_001153101
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IGMLVCE 9
           +G+LVC+
Sbjct: 369 VGLLVCK 375
>NP_003636
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IGMLVCE 9
           +G+LVC+
Sbjct: 422 VGLLVCK 428
>NP_997253
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIGMLVC 8
          A+G LVC
Sbjct: 11 AVGWLVC 17
>NP_001137159
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGMLVC 8
           IG+LVC
Sbjct: 533 IGLLVC 538
>XP_005251870
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AIGMLVC 8
           A+G+L+C
Sbjct: 94  AVGLLMC 100
>NP_001003750
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   FAIGMLVCE 9
           F +G++ CE
Sbjct: 103 FFVGLVCCE 111
>NP_073753
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2   AIGMLVC 8
           A+G+++C
Sbjct: 683 ALGLIIC 689
>NP_064541
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIGMLVC 8
          AIG L+C
Sbjct: 17 AIGFLLC 23
>NP_689854
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   GMLVCE 9
           G+L+CE
Sbjct: 388 GVLICE 393
>NP_683692
          Length = 3051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    GMLVCE 9
            G+L+CE
Sbjct: 1895 GVLICE 1900
>NP_114110
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AIGMLVC 8
           A+G LVC
Sbjct: 170 ALGALVC 176
>NP_060700
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3    IGMLVCE 9
            IG+ +CE
Sbjct: 1032 IGLYICE 1038
>NP_006832
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   AIGMLVC 8
           A+G+L C
Sbjct: 411 AVGLLTC 417
>XP_005261216
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AIGMLVCE 9
          A+G  VCE
Sbjct: 60 AMGFCVCE 67
>XP_006719336
          Length = 1779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   GMLVCE 9
           G+L+CE
Sbjct: 332 GVLICE 337
>XP_006719335
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   GMLVCE 9
           G+L+CE
Sbjct: 388 GVLICE 393
>XP_005274406
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AIGMLVC 8
           A+G LVC
Sbjct: 136 ALGALVC 142
>XP_006715822
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIGMLVC 8
          AIG L+C
Sbjct: 17 AIGFLLC 23
>XP_005249870
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIGMLVC 8
          AIG L+C
Sbjct: 17 AIGFLLC 23
>XP_005249869
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  AIGMLVC 8
          AIG L+C
Sbjct: 25 AIGFLLC 31
>XP_005248208
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    GMLVCE 9
            G+L+CE
Sbjct: 1895 GVLICE 1900
>XP_005248207
          Length = 3098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    GMLVCE 9
            G+L+CE
Sbjct: 1895 GVLICE 1900
>XP_006714021
          Length = 3112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    GMLVCE 9
            G+L+CE
Sbjct: 1895 GVLICE 1900
>XP_005265461
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2   AIGMLVC 8
           A+G+++C
Sbjct: 617 ALGLIIC 623
>XP_006713017
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   AIGMLVC 8
           A+G+L C
Sbjct: 411 AVGLLTC 417
>NP_703148
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   AIGMLVC 8
           A+G L+C
Sbjct: 472 AVGSLIC 478
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.154    0.509 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,865
Number of extensions: 766
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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