Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_115492                                                              18    1135
NP_001014402                                                           18    1135
XP_005266631                                                           18    1135
NP_001191005                                                           17    2528
NP_008975                                                              17    2528
NP_001026871                                                           17    2528
XP_005266862                                                           17    2528
XP_005266861                                                           17    2528
XP_006711211                                                           17    3301
NP_443197                                                              17    3301
NP_476506                                                              16    7355
NP_476505                                                              16    7355
NP_004360                                                              16    7355
NP_476508                                                              16    7355
NP_476507                                                              16    7355
NP_055080                                                              16    7355
XP_006716338                                                           16    7355
XP_005273438                                                           16    7355
XP_005273435                                                           16    7355
XP_006716336                                                           16    7355
XP_005246123                                                           16    7355
XP_005246122                                                           16    7355
XP_006712316                                                           16    7355
NP_004971                                                              15    9605
NP_751948                                                              15    9605
NP_006238                                                              15    9605
NP_001191213                                                           15    9605
NP_009115                                                              15    9605
NP_001138427                                                           15    9605
NP_001171482                                                           15    9605
NP_001171481                                                           15    9605
NP_064619                                                              15    9605
NP_694996                                                              15    9605
NP_009029                                                              15    9605
NP_002967                                                              15    9605
NP_001265227                                                           15    9605
NP_001826                                                              15    9605
NP_060557                                                              15    9605
NP_003495                                                              15    9605
XP_005261342                                                           15    9605
XP_005261343                                                           15    9605
XP_006724391                                                           15    9605
XP_005261338                                                           15    9605
XP_005277858                                                           15    9605
XP_006724390                                                           15    9605
XP_006724389                                                           15    9605
XP_005277857                                                           15    9605
XP_005254619                                                           15    9605
XP_005254618                                                           15    9605
XP_005250863                                                           15    9605
XP_006713018                                                           15    9605
XP_005264896                                                           15    9605
XP_006712745                                                           15    9605
XP_006712744                                                           15    9605
XP_006712743                                                           15    9605
XP_006710825                                                           15    9605
XP_006710695                                                           15    9605
XP_006710694                                                           15    9605
XP_006710693                                                           15    9605
XP_006710692                                                           15    9605
XP_005270908                                                           15    9605
NP_001162023                                                           15    9605
NP_659400                                                              15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EYDSSIVFY 9
           EYDS IVFY
Sbjct: 748 EYDSIIVFY 756
>NP_115492
          Length = 490

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDSS+V+Y
Sbjct: 22 YDSSMVYY 29
>NP_001014402
          Length = 490

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDSS+V+Y
Sbjct: 22 YDSSMVYY 29
>XP_005266631
          Length = 490

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDSS+V+Y
Sbjct: 22 YDSSMVYY 29
>NP_001191005
          Length = 311

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDS++V+Y
Sbjct: 22 YDSAMVYY 29
>NP_008975
          Length = 491

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDS++V+Y
Sbjct: 22 YDSAMVYY 29
>NP_001026871
          Length = 548

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EYDSSIVFY 9
           +YD ++VFY
Sbjct: 102 DYDYTLVFY 110
>XP_005266862
          Length = 438

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDS++V+Y
Sbjct: 22 YDSAMVYY 29
>XP_005266861
          Length = 491

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  YDSSIVFY 9
          YDS++V+Y
Sbjct: 22 YDSAMVYY 29
>XP_006711211
          Length = 183

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EYDSSIVFY 9
           E DS+IV+Y
Sbjct: 145 ESDSTIVYY 153
>NP_443197
          Length = 171

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EYDSSIVFY 9
           E DS+IV+Y
Sbjct: 145 ESDSTIVYY 153
>NP_476506
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 391 FDSSLVF 397
>NP_476505
          Length = 1036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 190 FDSSLVF 196
>NP_004360
          Length = 3177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 597 FDSSLVF 603
>NP_476508
          Length = 2971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 391 FDSSLVF 397
>NP_476507
          Length = 2570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 190 FDSSLVF 196
>NP_055080
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 658 DSSVVFH 664
>XP_006716338
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 568 DSSVVFH 574
>XP_005273438
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 658 DSSVVFH 664
>XP_005273435
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 658 DSSVVFH 664
>XP_006716336
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 658 DSSVVFH 664
>XP_005246123
          Length = 2770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 190 FDSSLVF 196
>XP_005246122
          Length = 2977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 597 FDSSLVF 603
>XP_006712316
          Length = 3010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YDSSIVF 8
           +DSS+VF
Sbjct: 597 FDSSLVF 603
>NP_004971
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>NP_751948
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>NP_006238
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EYDSSIVFY 9
          +Y+++I FY
Sbjct: 43 DYENAIKFY 51
>NP_001191213
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EYDSSIVFY 9
          +Y+++I FY
Sbjct: 43 DYENAIKFY 51
>NP_009115
          Length = 1504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SSIVFY 9
            SS+VFY
Sbjct: 1164 SSVVFY 1169
>NP_001138427
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EYDSSIVFY 9
           +YD+ + FY
Sbjct: 273 QYDNLLFFY 281
>NP_001171482
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EYDSSIVFY 9
           EYD  +V Y
Sbjct: 227 EYDLRLVLY 235
>NP_001171481
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EYDSSIVFY 9
           EYD  +V Y
Sbjct: 305 EYDLRLVLY 313
>NP_064619
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EYDSSIVFY 9
           +YD+ + FY
Sbjct: 273 QYDNLLFFY 281
>NP_694996
          Length = 2526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 777 DSSLVFH 783
>NP_009029
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 900 YDSSVV 905
>NP_002967
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YDSSIVFY 9
           +DS IVF+
Sbjct: 572 FDSMIVFH 579
>NP_001265227
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DSSIVFY 9
           DSS+VF+
Sbjct: 777 DSSLVFH 783
>NP_001826
          Length = 1583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 900 YDSSVV 905
>NP_060557
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  YDSSIVFY 9
          Y S ++FY
Sbjct: 66 YSSYVIFY 73
>NP_003495
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EYDSSIVFY 9
           EYD  +V Y
Sbjct: 273 EYDLRLVLY 281
>XP_005261342
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EYDSSIVFY 9
           EYD  +V Y
Sbjct: 305 EYDLRLVLY 313
>XP_005261343
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EYDSSIVFY 9
           EYD  +V Y
Sbjct: 273 EYDLRLVLY 281
>XP_006724391
          Length = 1567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 921 YDSSVV 926
>XP_005261338
          Length = 1570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 921 YDSSVV 926
>XP_005277858
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 921 YDSSVV 926
>XP_006724390
          Length = 1623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 883 YDSSVV 888
>XP_006724389
          Length = 1653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 921 YDSSVV 926
>XP_005277857
          Length = 1661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YDSSIV 7
           YDSS+V
Sbjct: 921 YDSSVV 926
>XP_005254619
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EYDSSIVFY 9
           +YD+ + FY
Sbjct: 273 QYDNLLFFY 281
>XP_005254618
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EYDSSIVFY 9
           +YD+ + FY
Sbjct: 273 QYDNLLFFY 281
>XP_005250863
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  EYDSSIVFY 9
          EY+  +V Y
Sbjct: 32 EYEKQVVLY 40
>XP_006713018
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SSIVFY 9
           SS+VFY
Sbjct: 658 SSVVFY 663
>XP_005264896
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SSIVFY 9
           SS+VFY
Sbjct: 773 SSVVFY 778
>XP_006712745
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YDSSIVFY 9
           +DS IVF+
Sbjct: 572 FDSMIVFH 579
>XP_006712744
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YDSSIVFY 9
           +DS IVF+
Sbjct: 572 FDSMIVFH 579
>XP_006712743
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YDSSIVFY 9
           +DS IVF+
Sbjct: 572 FDSMIVFH 579
>XP_006710825
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  YDSSIVFY 9
          Y S ++FY
Sbjct: 61 YSSYVIFY 68
>XP_006710695
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>XP_006710694
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>XP_006710693
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>XP_006710692
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>XP_005270908
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 5/8 (62%)

Query: 2   YDSSIVFY 9
           YD  + FY
Sbjct: 114 YDDELAFY 121
>NP_001162023
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  YDSSIVFY 9
          Y S ++FY
Sbjct: 66 YSSYVIFY 73
>NP_659400
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  EYDSSIVFY 9
          EY+  +V Y
Sbjct: 32 EYEKQVVLY 40
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.140    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,264
Number of extensions: 746
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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