Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
NP_573568                                                              18    1482
XP_005259549                                                           18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
NP_775082                                                              16    5631
NP_003377                                                              16    5631
NP_001035536                                                           16    5631
XP_005248374                                                           16    5631
XP_005248373                                                           16    5631
XP_005248371                                                           16    5631
XP_005248370                                                           16    5631
NP_001186308                                                           16    7355
NP_001186307                                                           16    7355
NP_065923                                                              16    7355
NP_060522                                                              16    7355
NP_004184                                                              16    7355
XP_005259586                                                           16    7355
XP_005256097                                                           16    7355
XP_006718114                                                           16    7355
XP_005270318                                                           16    7355
XP_006718113                                                           16    7355
XP_006718112                                                           16    7355
XP_006718111                                                           16    7355
XP_006718110                                                           16    7355
XP_005264816                                                           16    7355
XP_005264815                                                           16    7355
XP_005264814                                                           16    7355
NP_036567                                                              16    7355
NP_000436                                                              15    9605
NP_958780                                                              15    9605
NP_958781                                                              15    9605
NP_958785                                                              15    9605
NP_958783                                                              15    9605
NP_958786                                                              15    9605
NP_067653                                                              15    9605
NP_004658                                                              15    9605
NP_001284                                                              15    9605
NP_001177779                                                           15    9605
NP_001177776                                                           15    9605
NP_037448                                                              15    9605
NP_001008226                                                           15    9605
NP_001177778                                                           15    9605
NP_001177777                                                           15    9605
NP_958782                                                              15    9605
NP_958784                                                              15    9605
NP_473366                                                              15    9605
NP_116221                                                              15    9605
NP_061114                                                              15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_005271567                                                           15    9605
XP_005271566                                                           15    9605
XP_005271565                                                           15    9605
XP_005271564                                                           15    9605
XP_005271563                                                           15    9605
XP_005251041                                                           15    9605
XP_005251040                                                           15    9605
XP_006716653                                                           15    9605
XP_006716652                                                           15    9605
XP_005251039                                                           15    9605
XP_005251038                                                           15    9605
XP_005251036                                                           15    9605
XP_005251037                                                           15    9605
XP_005251035                                                           15    9605
XP_006716651                                                           15    9605
XP_005251034                                                           15    9605
XP_005251033                                                           15    9605
XP_006715647                                                           15    9605
XP_006715646                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            EVV TEDAL
Sbjct: 2466 EVVLTEDAL 2474
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            EVV TEDAL
Sbjct: 2458 EVVLTEDAL 2466
>NP_573568
          Length = 312

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           EV +TEDAL
Sbjct: 114 EVTKTEDAL 122
>XP_005259549
          Length = 1349

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           EV +TEDAL
Sbjct: 114 EVTKTEDAL 122
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            EVV TEDAL
Sbjct: 2419 EVVLTEDAL 2427
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            EVV TEDAL
Sbjct: 2498 EVVLTEDAL 2506
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            EVV TEDAL
Sbjct: 2511 EVVLTEDAL 2519
>NP_775082
          Length = 2721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VRTEDAL 9
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_003377
          Length = 2812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VRTEDAL 9
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_001035536
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVVRTED 7
           E+V+TED
Sbjct: 310 EIVKTED 316
>XP_005248374
          Length = 377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVVRTED 7
           E+V+TED
Sbjct: 310 EIVKTED 316
>XP_005248373
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVVRTED 7
           E+V+TED
Sbjct: 310 EIVKTED 316
>XP_005248371
          Length = 711

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVVRTED 7
           E+V+TED
Sbjct: 310 EIVKTED 316
>XP_005248370
          Length = 767

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVVRTED 7
           E+V+TED
Sbjct: 310 EIVKTED 316
>NP_001186308
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>NP_001186307
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>NP_065923
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           E VRTE+A+
Sbjct: 691 EKVRTEEAV 699
>NP_060522
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EVVRTEDAL 9
           E+++TED+L
Sbjct: 724 ELLQTEDSL 732
>NP_004184
          Length = 1859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_005259586
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVRTEDAL 9
           VVRT+D L
Sbjct: 383 VVRTKDVL 390
>XP_005256097
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EVVRTEDAL 9
           E+++TED+L
Sbjct: 696 ELLQTEDSL 704
>XP_006718114
          Length = 1850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_005270318
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_006718113
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_006718112
          Length = 1889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_006718111
          Length = 1892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_006718110
          Length = 1893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EVVRTED 7
          EV+R+ED
Sbjct: 70 EVIRSED 76
>XP_005264816
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           E VRTE+A+
Sbjct: 310 EKVRTEEAV 318
>XP_005264815
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           E VRTE+A+
Sbjct: 586 EKVRTEEAV 594
>XP_005264814
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVVRTEDAL 9
           E VRTE+A+
Sbjct: 691 EKVRTEEAV 699
>NP_036567
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVRTEDAL 9
           VVRT+D L
Sbjct: 540 VVRTKDVL 547
>NP_000436
          Length = 4574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1427 EVVRREEA 1434
>NP_958780
          Length = 4533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1386 EVVRREEA 1393
>NP_958781
          Length = 4525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1378 EVVRREEA 1385
>NP_958785
          Length = 4551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1404 EVVRREEA 1411
>NP_958783
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1368 EVVRREEA 1375
>NP_958786
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1400 EVVRREEA 1407
>NP_067653
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EVVRTED 7
          E+VRT D
Sbjct: 75 EIVRTRD 81
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            E+V +EDA+
Sbjct: 3471 EIVSSEDAV 3479
>NP_001284
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           VRTED++
Sbjct: 205 VRTEDSI 211
>NP_001177779
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_001177776
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_037448
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_001008226
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_001177778
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_001177777
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRTEDAL 9
           +R+EDAL
Sbjct: 164 IRSEDAL 170
>NP_958782
          Length = 4684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1537 EVVRREEA 1544
>NP_958784
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1400 EVVRREEA 1407
>NP_473366
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 65 EVVRTE 70
>NP_116221
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVRTEDAL 9
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
>NP_061114
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 65 EVVRTE 70
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            E+V +EDA+
Sbjct: 3385 EIVSSEDAV 3393
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            E+V +EDA+
Sbjct: 3433 EIVSSEDAV 3441
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            E+V +EDA+
Sbjct: 3433 EIVSSEDAV 3441
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EVVRTEDAL 9
            E+V +EDA+
Sbjct: 3466 EIVSSEDAV 3474
>XP_005271567
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 78 EVVRTE 83
>XP_005271566
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 78 EVVRTE 83
>XP_005271565
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 78 EVVRTE 83
>XP_005271564
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 78 EVVRTE 83
>XP_005271563
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  EVVRTE 6
          EVVRTE
Sbjct: 78 EVVRTE 83
>XP_005251041
          Length = 4520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1373 EVVRREEA 1380
>XP_005251040
          Length = 4524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1377 EVVRREEA 1384
>XP_006716653
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1382 EVVRREEA 1389
>XP_006716652
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1382 EVVRREEA 1389
>XP_005251039
          Length = 4530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1383 EVVRREEA 1390
>XP_005251038
          Length = 4538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1391 EVVRREEA 1398
>XP_005251036
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1405 EVVRREEA 1412
>XP_005251037
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1405 EVVRREEA 1412
>XP_005251035
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1409 EVVRREEA 1416
>XP_006716651
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1432 EVVRREEA 1439
>XP_005251034
          Length = 4685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1538 EVVRREEA 1545
>XP_005251033
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EVVRTEDA 8
            EVVR E+A
Sbjct: 1542 EVVRREEA 1549
>XP_006715647
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVRTEDAL 9
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
>XP_006715646
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVRTEDAL 9
           ++RT+D+L
Sbjct: 104 IIRTKDSL 111
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.128    0.307 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 454,221
Number of extensions: 697
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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