Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              19     665
XP_006714104                                                           19     665
XP_005265800                                                           19     665
XP_006714103                                                           19     665
XP_006714102                                                           19     665
XP_006714896                                                           17    2528
NP_079429                                                              17    2528
NP_001276062                                                           17    4312
NP_001002860                                                           17    4312
NP_036433                                                              17    4312
XP_006725229                                                           17    4312
XP_006720258                                                           17    4312
XP_005250782                                                           17    4312
NP_870987                                                              16    5631
NP_001164056                                                           16    5631
NP_694566                                                              16    5631
XP_006716781                                                           16    5631
XP_005251409                                                           16    5631
XP_005251408                                                           16    5631
XP_006716780                                                           16    5631
NP_006751                                                              16    7355
NP_001185928                                                           16    7355
NP_705872                                                              16    7355
NP_705871                                                              16    7355
NP_079242                                                              16    7355
NP_705870                                                              16    7355
NP_705869                                                              16    7355
NP_065909                                                              16    7355
XP_005254747                                                           16    7355
XP_005254746                                                           16    7355
XP_005254745                                                           16    7355
XP_005254744                                                           16    7355
XP_005254743                                                           16    7355
XP_005254742                                                           16    7355
XP_006712812                                                           16    7355
XP_005263827                                                           16    7355
XP_005263826                                                           16    7355
XP_005263825                                                           16    7355
XP_005263824                                                           16    7355
XP_006712811                                                           16    7355
XP_001718723                                                           16    7355
NP_078821                                                              16    7355
NP_001139400                                                           16    7355
NP_004309                                                              15    9605
NP_003676                                                              15    9605
NP_060997                                                              15    9605
NP_001104268                                                           15    9605
NP_000037                                                              15    9605
NP_078837                                                              15    9605
NP_001158222                                                           15    9605
NP_058651                                                              15    9605
NP_543145                                                              15    9605
NP_001186867                                                           15    9605
XP_005259725                                                           15    9605
XP_005266579                                                           15    9605
XP_006719929                                                           15    9605
XP_006716512                                                           15    9605
XP_005251307                                                           15    9605
XP_005251306                                                           15    9605
XP_005251305                                                           15    9605
XP_005251304                                                           15    9605
XP_005251303                                                           15    9605
XP_006716511                                                           15    9605
XP_005251301                                                           15    9605
XP_005251300                                                           15    9605
XP_005251299                                                           15    9605
XP_005251298                                                           15    9605
XP_005251297                                                           15    9605
XP_005251296                                                           15    9605
XP_005251295                                                           15    9605
XP_005251293                                                           15    9605
XP_005251292                                                           15    9605
XP_005248225                                                           15    9605
XP_006714028                                                           15    9605
>NP_006197
          Length = 1089

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVSRQYPMS 9
          EVS QYPMS
Sbjct: 54 EVSWQYPMS 62
>XP_006714104
          Length = 832

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVSRQYPMS 9
          EVS QYPMS
Sbjct: 79 EVSWQYPMS 87
>XP_005265800
          Length = 1089

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVSRQYPMS 9
          EVS QYPMS
Sbjct: 54 EVSWQYPMS 62
>XP_006714103
          Length = 1111

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVSRQYPMS 9
          EVS QYPMS
Sbjct: 76 EVSWQYPMS 84
>XP_006714102
          Length = 1114

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVSRQYPMS 9
          EVS QYPMS
Sbjct: 79 EVSWQYPMS 87
>XP_006714896
          Length = 1461

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EVSRQYP 7
          EVSR+YP
Sbjct: 61 EVSRRYP 67
>NP_079429
          Length = 1461

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EVSRQYP 7
          EVSR+YP
Sbjct: 61 EVSRRYP 67
>NP_001276062
          Length = 781

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E  R+YP+S
Sbjct: 653 EARREYPLS 661
>NP_001002860
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    EVSRQYPMS 9
            E  R+YP+S
Sbjct: 1004 EARREYPLS 1012
>NP_036433
          Length = 1455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SRQYPMS 9
            +RQYP+S
Sbjct: 1129 TRQYPLS 1135
>XP_006725229
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    EVSRQYPMS 9
            E  R+YP+S
Sbjct: 1004 EARREYPLS 1012
>XP_006720258
          Length = 1132

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    EVSRQYPMS 9
            E  R+YP+S
Sbjct: 1004 EARREYPLS 1012
>XP_005250782
          Length = 1441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SRQYPMS 9
            +RQYP+S
Sbjct: 1115 TRQYPLS 1121
>NP_870987
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 333 RQYPLS 338
>NP_001164056
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EVSRQY 6
           EVSRQY
Sbjct: 233 EVSRQY 238
>NP_694566
          Length = 1458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EVSRQY 6
           EVSRQY
Sbjct: 222 EVSRQY 227
>XP_006716781
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 159 RQYPLS 164
>XP_005251409
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 333 RQYPLS 338
>XP_005251408
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 333 RQYPLS 338
>XP_006716780
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 333 RQYPLS 338
>NP_006751
          Length = 184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E SR+ PMS
Sbjct: 128 ESSREIPMS 136
>NP_001185928
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_705872
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_705871
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_079242
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_705870
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_705869
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>NP_065909
          Length = 1011

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254747
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254746
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254745
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254744
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254743
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_005254742
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SRQYPM 8
          SRQYP+
Sbjct: 38 SRQYPV 43
>XP_006712812
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 515 RQYPVS 520
>XP_005263827
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 488 RQYPVS 493
>XP_005263826
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 489 RQYPVS 494
>XP_005263825
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 489 RQYPVS 494
>XP_005263824
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 514 RQYPVS 519
>XP_006712811
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 515 RQYPVS 520
>XP_001718723
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VSRQYPMS 9
           V+R YPM+
Sbjct: 193 VTRTYPMT 200
>NP_078821
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 515 RQYPVS 520
>NP_001139400
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RQYPMS 9
           RQYP+S
Sbjct: 515 RQYPVS 520
>NP_004309
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 366 ELVRKYPQS 374
>NP_003676
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EVSRQYP 7
           E+SRQ P
Sbjct: 459 EISRQLP 465
>NP_060997
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           E+S+Q+P
Sbjct: 282 EISKQHP 288
>NP_001104268
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           E+S+Q+P
Sbjct: 282 EISKQHP 288
>NP_000037
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           ++SR+YP
Sbjct: 486 DLSREYP 492
>NP_078837
          Length = 864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           E+S+Q+P
Sbjct: 282 EISKQHP 288
>NP_001158222
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 337 ELVRKYPQS 345
>NP_058651
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   EVSRQYP 7
           E+S+ YP
Sbjct: 305 EISKMYP 311
>NP_543145
          Length = 111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EVSRQYP 7
          +VSR YP
Sbjct: 86 DVSRPYP 92
>NP_001186867
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  SRQYP 7
          SRQYP
Sbjct: 36 SRQYP 40
>XP_005259725
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EVSRQYP 7
           E+SRQ P
Sbjct: 459 EISRQLP 465
>XP_005266579
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           E+S+Q+P
Sbjct: 282 EISKQHP 288
>XP_006719929
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EVSRQYP 7
           E+S+Q+P
Sbjct: 282 EISKQHP 288
>XP_006716512
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 171 ELVRKYPQS 179
>XP_005251307
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 304 ELVRKYPQS 312
>XP_005251306
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 309 ELVRKYPQS 317
>XP_005251305
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 318 ELVRKYPQS 326
>XP_005251304
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 319 ELVRKYPQS 327
>XP_005251303
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 323 ELVRKYPQS 331
>XP_006716511
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 323 ELVRKYPQS 331
>XP_005251301
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 332 ELVRKYPQS 340
>XP_005251300
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 338 ELVRKYPQS 346
>XP_005251299
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 347 ELVRKYPQS 355
>XP_005251298
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 351 ELVRKYPQS 359
>XP_005251297
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 352 ELVRKYPQS 360
>XP_005251296
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 362 ELVRKYPQS 370
>XP_005251295
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 366 ELVRKYPQS 374
>XP_005251293
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 380 ELVRKYPQS 388
>XP_005251292
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVSRQYPMS 9
           E+ R+YP S
Sbjct: 381 ELVRKYPQS 389
>XP_005248225
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   EVSRQYP 7
           E+S+ YP
Sbjct: 226 EISKMYP 232
>XP_006714028
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   EVSRQYP 7
           E+S+ YP
Sbjct: 245 EISKMYP 251
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.119    0.321 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,696
Number of extensions: 613
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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