Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_002072                                                              18    1935
NP_006150                                                              17    3301
NP_001138582                                                           17    3301
NP_001138581                                                           17    3301
NP_001138580                                                           17    3301
NP_001138579                                                           17    3301
XP_005268962                                                           17    3301
NP_001273206                                                           16    5631
NP_001273207                                                           16    5631
NP_001273208                                                           16    5631
NP_006313                                                              16    5631
NP_076404                                                              16    5631
XP_005268350                                                           16    5631
NP_115495                                                              16    7355
NP_079170                                                              16    7355
NP_997191                                                              16    7355
NP_001248323                                                           16    7355
NP_001248321                                                           16    7355
NP_001152956                                                           16    7355
NP_835231                                                              16    7355
NP_065810                                                              16    7355
XP_006720684                                                           16    7355
XP_006713679                                                           16    7355
XP_006713678                                                           16    7355
XP_005247487                                                           16    7355
XP_005247486                                                           16    7355
XP_006711682                                                           16    7355
NP_001012985                                                           15    9605
NP_001275582                                                           15    9605
NP_004850                                                              15    9605
NP_112219                                                              15    9605
NP_004791                                                              15    9605
NP_001129203                                                           15    9605
NP_078921                                                              15    9605
XP_006722979                                                           15    9605
XP_005257069                                                           15    9605
XP_006716463                                                           15    9605
XP_006716462                                                           15    9605
XP_005263404                                                           15    9605
XP_005263403                                                           15    9605
XP_006714474                                                           15    9605
XP_006714473                                                           15    9605
XP_006714472                                                           15    9605
XP_005263402                                                           15    9605
XP_005263401                                                           15    9605
XP_005263399                                                           15    9605
XP_005263400                                                           15    9605
XP_006714471                                                           15    9605
XP_005263398                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           VRLYYRVM
Sbjct: 450 VRLYYRVM 457
>NP_002072
          Length = 558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           E+RLYYR
Sbjct: 147 ELRLYYR 153
>NP_006150
          Length = 816

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 124 EVRLHYR 130
>NP_001138582
          Length = 839

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 147 EVRLHYR 153
>NP_001138581
          Length = 815

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 123 EVRLHYR 129
>NP_001138580
          Length = 816

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 124 EVRLHYR 130
>NP_001138579
          Length = 866

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 174 EVRLHYR 180
>XP_005268962
          Length = 816

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+YR
Sbjct: 124 EVRLHYR 130
>NP_001273206
          Length = 897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           E+R YYR++
Sbjct: 321 ELREYYRLL 329
>NP_001273207
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           E+R YYR++
Sbjct: 331 ELREYYRLL 339
>NP_001273208
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           E+R YYR++
Sbjct: 331 ELREYYRLL 339
>NP_006313
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           E+R YYR++
Sbjct: 331 ELREYYRLL 339
>NP_076404
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVRLYY 6
           EVR+YY
Sbjct: 348 EVRIYY 353
>XP_005268350
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           E+R YYR++
Sbjct: 331 ELREYYRLL 339
>NP_115495
          Length = 6306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VRLYYRVM 9
            VRL+Y+ M
Sbjct: 4298 VRLWYKTM 4305
>NP_079170
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EVRLYYRV 8
           ++RLY++V
Sbjct: 405 DIRLYHKV 412
>NP_997191
          Length = 1888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           EV++Y+ +M
Sbjct: 458 EVKIYFPIM 466
>NP_001248323
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EVRLYYRV 8
           ++RLY++V
Sbjct: 355 DIRLYHKV 362
>NP_001248321
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EVRLYYRV 8
           ++RLY++V
Sbjct: 379 DIRLYHKV 386
>NP_001152956
          Length = 1736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           EV++Y+ +M
Sbjct: 458 EVKIYFPIM 466
>NP_835231
          Length = 263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+Y+
Sbjct: 140 EVRLFYQ 146
>NP_065810
          Length = 4700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VRLYYRV 8
            V+LYY+V
Sbjct: 4528 VQLYYKV 4534
>XP_006720684
          Length = 4713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VRLYYRV 8
            V+LYY+V
Sbjct: 4541 VQLYYKV 4547
>XP_006713679
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+Y+
Sbjct: 138 EVRLFYQ 144
>XP_006713678
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+Y+
Sbjct: 162 EVRLFYQ 168
>XP_005247487
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+Y+
Sbjct: 201 EVRLFYQ 207
>XP_005247486
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRLYYR 7
           EVRL+Y+
Sbjct: 213 EVRLFYQ 219
>XP_006711682
          Length = 1739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           EV++Y+ +M
Sbjct: 309 EVKIYFPIM 317
>NP_001012985
          Length = 1706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>NP_001275582
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    VRLYYRVM 9
            V LYYR +
Sbjct: 1405 VELYYRAI 1412
>NP_004850
          Length = 1675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    VRLYYRVM 9
            V LYYR +
Sbjct: 1401 VELYYRAI 1408
>NP_112219
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EVRLYYRV 8
          E RL+Y+V
Sbjct: 73 ESRLFYKV 80
>NP_004791
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   EVRLYYRVM 9
           ++++YY V+
Sbjct: 213 DIKIYYHVV 221
>NP_001129203
          Length = 153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EVRLYY 6
          +VRLYY
Sbjct: 41 KVRLYY 46
>NP_078921
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EVRLYY 6
          +VRLYY
Sbjct: 41 KVRLYY 46
>XP_006722979
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EVRLYYRV 8
          E RL+Y+V
Sbjct: 73 ESRLFYKV 80
>XP_005257069
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    VRLYYRVM 9
            V LYYR +
Sbjct: 1401 VELYYRAI 1408
>XP_006716463
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EVRLYY 6
          +VRLYY
Sbjct: 46 KVRLYY 51
>XP_006716462
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EVRLYY 6
          +VRLYY
Sbjct: 46 KVRLYY 51
>XP_005263404
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263403
          Length = 1672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_006714474
          Length = 1674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_006714473
          Length = 1675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_006714472
          Length = 1706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263402
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263401
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263399
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263400
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_006714471
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
>XP_005263398
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VRLYYRVM 9
           +R+Y+RV+
Sbjct: 272 LRMYHRVL 279
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.152    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 460,254
Number of extensions: 616
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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