Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           18    1135
NP_001257437                                                           18    1135
NP_006281                                                              18    1135
XP_005267176                                                           18    1135
NP_001153705                                                           16    7355
NP_000692                                                              16    7355
NP_001153706                                                           16    7355
NP_001735                                                              16    7355
XP_006710718                                                           16    7355
NP_570848                                                              15    9605
NP_570850                                                              15    9605
NP_570849                                                              15    9605
NP_570844                                                              15    9605
NP_570845                                                              15    9605
NP_570846                                                              15    9605
NP_570847                                                              15    9605
NP_056375                                                              15    9605
NP_115646                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_004749                                                              15    9605
NP_077729                                                              15    9605
NP_001248764                                                           15    9605
XP_006722241                                                           15    9605
XP_006722240                                                           15    9605
XP_006722238                                                           15    9605
XP_005257864                                                           15    9605
XP_006722237                                                           15    9605
XP_006722236                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
XP_006711023                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_001257436
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVRKLVVLK 9
          EVRKLV LK
Sbjct: 88 EVRKLVALK 96
>NP_001257437
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVRKLVVLK 9
          EVRKLV LK
Sbjct: 88 EVRKLVALK 96
>NP_006281
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVRKLVVLK 9
          EVRKLV LK
Sbjct: 88 EVRKLVALK 96
>XP_005267176
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EVRKLVVLK 9
          EVRKLV LK
Sbjct: 88 EVRKLVALK 96
>NP_001153705
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EVRKLVV 7
            EVRKL++
Sbjct: 1003 EVRKLII 1009
>NP_000692
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EVRKLVV 7
            EVRKL++
Sbjct: 1003 EVRKLII 1009
>NP_001153706
          Length = 992

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRKLVV 7
           EVRKL++
Sbjct: 972 EVRKLII 978
>NP_001735
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRKLVVL 8
           VRKL+VL
Sbjct: 277 VRKLIVL 283
>XP_006710718
          Length = 992

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVRKLVV 7
           EVRKL++
Sbjct: 972 EVRKLII 978
>NP_570848
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 261 ELRKLVLQK 269
>NP_570850
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 297 ELRKLVLQK 305
>NP_570849
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 279 ELRKLVLQK 287
>NP_570844
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 206 ELRKLVLQK 214
>NP_570845
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 224 ELRKLVLQK 232
>NP_570846
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 243 ELRKLVLQK 251
>NP_570847
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 260 ELRKLVLQK 268
>NP_056375
          Length = 960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EVRKLVVLK 9
           E+RKLV+ K
Sbjct: 242 ELRKLVLQK 250
>NP_115646
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRKLVVLK 9
           +RKL VLK
Sbjct: 636 LRKLTVLK 643
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 18615 DLRKVVVLR 18623
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 18740 DLRKVVVLR 18748
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 26039 DLRKVVVLR 26047
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 25112 DLRKVVVLR 25120
>NP_004749
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 795 RRLVVLK 801
>NP_077729
          Length = 1797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 735 RRLVVLK 741
>NP_001248764
          Length = 1848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 795 RRLVVLK 801
>XP_006722241
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 355 RRLVVLK 361
>XP_006722240
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 355 RRLVVLK 361
>XP_006722238
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 735 RRLVVLK 741
>XP_005257864
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 795 RRLVVLK 801
>XP_006722237
          Length = 1900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 788 RRLVVLK 794
>XP_006722236
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RKLVVLK 9
           R+LVVLK
Sbjct: 795 RRLVVLK 801
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 14352 DLRKVVVLR 14360
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 15711 DLRKVVVLR 15719
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 25667 DLRKVVVLR 25675
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 27173 DLRKVVVLR 27181
>XP_006711023
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRKLVVLK 9
           +RKL VLK
Sbjct: 641 LRKLTVLK 648
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 27680 DLRKVVVLR 27688
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1     EVRKLVVLK 9
             ++RK+VVL+
Sbjct: 18807 DLRKVVVLR 18815
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.145    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 345,622
Number of extensions: 489
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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