Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     869
NP_114111                                                              16    5631
NP_001128342                                                           16    5631
NP_597728                                                              16    5631
NP_001154485                                                           16    5631
NP_001154483                                                           16    5631
NP_001154482                                                           16    5631
NP_001154481                                                           16    5631
NP_001154484                                                           16    5631
XP_005250685                                                           16    5631
XP_005250684                                                           16    5631
XP_005250683                                                           16    5631
XP_005250682                                                           16    5631
XP_005250681                                                           16    5631
XP_005250680                                                           16    5631
XP_005250679                                                           16    5631
XP_005250678                                                           16    5631
NP_061986                                                              16    7355
XP_005258788                                                           16    7355
NP_003931                                                              15    9605
NP_001263215                                                           15    9605
NP_056169                                                              15    9605
XP_005256331                                                           15    9605
NP_001122107                                                           15    9605
NP_001122105                                                           15    9605
NP_001091643                                                           15    9605
NP_056487                                                              15    9605

>NP_443179
          Length = 2170

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   EVGVRSSR 8
           EVGVRSSR
Sbjct: 409 EVGVRSSR 416



>NP_114111
          Length = 343

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_001128342
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EVGVRSSR 8
           EVG RSSR
Sbjct: 178 EVGDRSSR 185



>NP_597728
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EVGVRSSR 8
           EVG RSSR
Sbjct: 178 EVGDRSSR 185



>NP_001154485
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_001154483
          Length = 284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_001154482
          Length = 284

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_001154481
          Length = 308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_001154484
          Length = 249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250685
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250684
          Length = 204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250683
          Length = 204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250682
          Length = 204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250681
          Length = 271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250680
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250679
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>XP_005250678
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EVGVRSSR 8
          E+G+RSS+
Sbjct: 37 ELGIRSSK 44



>NP_061986
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGVRSSRF 9
           +GV++SRF
Sbjct: 94  LGVKTSRF 101



>XP_005258788
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGVRSSRF 9
           +GV++SRF
Sbjct: 94  LGVKTSRF 101



>NP_003931
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GVRSSRF 9
           GV++SRF
Sbjct: 568 GVKTSRF 574



>NP_001263215
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VGVRSSR 8
           VG RSSR
Sbjct: 332 VGARSSR 338



>NP_056169
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EVGVRSSRF 9
          E+G+R S+F
Sbjct: 73 ELGLRISKF 81



>XP_005256331
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVGVRSS 7
           E+G+RSS
Sbjct: 364 ELGIRSS 370



>NP_001122107
          Length = 1639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EVGVRS 6
           EVGVRS
Sbjct: 255 EVGVRS 260



>NP_001122105
          Length = 1639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EVGVRS 6
           EVGVRS
Sbjct: 255 EVGVRS 260



>NP_001091643
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVGVRSS 7
           E+G+RSS
Sbjct: 364 ELGIRSS 370



>NP_056487
          Length = 1639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EVGVRS 6
           EVGVRS
Sbjct: 255 EVGVRS 260



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.136    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 335,922
Number of extensions: 398
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)