Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1935
NP_055078                                                              17    2528
NP_647473                                                              17    2528
NP_001240795                                                           17    2528
NP_001017423                                                           17    4312
NP_002851                                                              17    4312
XP_006717996                                                           17    4312
NP_848591                                                              17    4312
NP_001195                                                              16    5631
NP_000318                                                              16    5631
NP_079452                                                              16    5631
NP_064612                                                              16    5631
XP_005260736                                                           16    5631
XP_006723616                                                           16    5631
XP_006723615                                                           16    5631
XP_005260735                                                           16    5631
XP_005256332                                                           16    5631
XP_006714452                                                           16    5631
XP_005263363                                                           16    5631
XP_005263362                                                           16    5631
XP_006714426                                                           16    5631
XP_006714425                                                           16    5631
XP_006714424                                                           16    5631
XP_006714423                                                           16    5631
XP_006714420                                                           16    5631
XP_006714419                                                           16    5631
XP_006714418                                                           16    5631
XP_006714417                                                           16    5631
XP_005263359                                                           16    5631
XP_006714416                                                           16    5631
XP_006714415                                                           16    5631
XP_006714414                                                           16    5631
XP_006714413                                                           16    5631
XP_006714412                                                           16    5631
XP_006714411                                                           16    5631
XP_006714410                                                           16    5631
XP_006714409                                                           16    5631
XP_006714408                                                           16    5631
NP_001152980                                                           16    7355
NP_002216                                                              16    7355
NP_001265281                                                           16    7355
NP_055797                                                              16    7355
NP_653167                                                              16    7355
NP_001012747                                                           16    7355
NP_073616                                                              16    7355
NP_001258777                                                           16    7355
XP_005267484                                                           16    7355
XP_005267483                                                           16    7355
XP_005267482                                                           16    7355
XP_005267481                                                           16    7355
XP_005267480                                                           16    7355
XP_005267479                                                           16    7355
XP_005267478                                                           16    7355
XP_005267477                                                           16    7355
XP_006717299                                                           16    7355
XP_005272263                                                           16    7355
XP_005251533                                                           16    7355
XP_006716840                                                           16    7355
XP_006715690                                                           16    7355
NP_002188                                                              16    7355
NP_001012771                                                           16    7355
NP_619526                                                              16    7355
NP_000949                                                              15    9605
NP_004647                                                              15    9605
NP_001269659                                                           15    9605
NP_055675                                                              15    9605
NP_001269661                                                           15    9605
NP_001269660                                                           15    9605
NP_001269658                                                           15    9605
NP_653292                                                              15    9605
XP_005248384                                                           15    9605
XP_005248383                                                           15    9605
XP_005264729                                                           15    9605
>NP_443179
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           EVGV SSRV
Sbjct: 409 EVGVRSSRV 417
>NP_055078
          Length = 716

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           VGVG+SR+
Sbjct: 356 VGVGASRI 363
>NP_647473
          Length = 773

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           VGVG+SR+
Sbjct: 413 VGVGASRI 420
>NP_001240795
          Length = 683

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           VGVG+SR+
Sbjct: 323 VGVGASRI 330
>NP_001017423
          Length = 793

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           EVG+ +SR+
Sbjct: 736 EVGISTSRI 744
>NP_002851
          Length = 795

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           EVG+ +SR+
Sbjct: 738 EVGISTSRI 746
>XP_006717996
          Length = 795

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           EVG+ +SR+
Sbjct: 738 EVGISTSRI 746
>NP_848591
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           +GVGSSR+
Sbjct: 224 LGVGSSRM 231
>NP_001195
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EVGVGSSRV 9
          ++G+G SR+
Sbjct: 43 DLGIGESRI 51
>NP_000318
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VGVGSSR 8
          VGVG+SR
Sbjct: 79 VGVGASR 85
>NP_079452
          Length = 1382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           E+GVGSS
Sbjct: 207 ELGVGSS 213
>NP_064612
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGVGSSRV 9
           VGVG SR+
Sbjct: 514 VGVGISRI 521
>XP_005260736
          Length = 1033

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           E+GVGSS
Sbjct: 207 ELGVGSS 213
>XP_006723616
          Length = 1223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EVGVGSS 7
          E+GVGSS
Sbjct: 48 ELGVGSS 54
>XP_006723615
          Length = 1382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           E+GVGSS
Sbjct: 207 ELGVGSS 213
>XP_005260735
          Length = 1398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           E+GVGSS
Sbjct: 223 ELGVGSS 229
>XP_005256332
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VGVGSSRV 9
           VGVG SR+
Sbjct: 365 VGVGISRI 372
>XP_006714452
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263363
          Length = 1092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263362
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714426
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714425
          Length = 1155

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 114 GVGSSRL 120
>XP_006714424
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 145 GVGSSRL 151
>XP_006714423
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714420
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714419
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714418
          Length = 1300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714417
          Length = 1319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263359
          Length = 1340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714416
          Length = 1346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 305 GVGSSRL 311
>XP_006714415
          Length = 1347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714414
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 328 GVGSSRL 334
>XP_006714413
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 328 GVGSSRL 334
>XP_006714412
          Length = 1372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714411
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 336 GVGSSRL 342
>XP_006714410
          Length = 1385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714409
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714408
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GVGSSRV 9
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>NP_001152980
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVGVGSSRV 9
           E+G G+S V
Sbjct: 374 EIGAGTSEV 382
>NP_002216
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EVGVGSSRV 9
           E+G G+S V
Sbjct: 404 EIGAGTSEV 412
>NP_001265281
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EVGVGSSR 8
           E G GSSR
Sbjct: 773 EYGAGSSR 780
>NP_055797
          Length = 2341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>NP_653167
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           EVG+G+S
Sbjct: 133 EVGIGNS 139
>NP_001012747
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EVGVGSSRV 9
           E+GV  SRV
Sbjct: 137 EIGVPESRV 145
>NP_073616
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GVGSSRV 9
          G GSSRV
Sbjct: 75 GAGSSRV 81
>NP_001258777
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           EVG+G+S
Sbjct: 136 EVGIGNS 142
>XP_005267484
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267483
          Length = 2230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267482
          Length = 2243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267481
          Length = 2293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 100 QIGSGSSRL 108
>XP_005267480
          Length = 2336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267479
          Length = 2344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267478
          Length = 2348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_005267477
          Length = 2349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EVGVGSSRV 9
           ++G GSSR+
Sbjct: 156 QIGSGSSRL 164
>XP_006717299
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GVGSSRV 9
          G GSSRV
Sbjct: 75 GAGSSRV 81
>XP_005272263
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GVGSSRV 9
          G GSSRV
Sbjct: 75 GAGSSRV 81
>XP_005251533
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EVGVGSSR 8
           E G GSSR
Sbjct: 773 EYGAGSSR 780
>XP_006716840
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EVGVGSSR 8
           E G GSSR
Sbjct: 781 EYGAGSSR 788
>XP_006715690
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EVGVGSSRV 9
           E GVG SRV
Sbjct: 140 ERGVGLSRV 148
>NP_002188
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EVGVGSSR 8
           E G GSSR
Sbjct: 773 EYGAGSSR 780
>NP_001012771
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EVGVGSS 7
           EVG+G+S
Sbjct: 116 EVGIGNS 122
>NP_619526
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  GVGSSRV 9
          G GSSRV
Sbjct: 75 GAGSSRV 81
>NP_000949
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
>NP_004647
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GVGSSRV 9
           GVG SRV
Sbjct: 380 GVGRSRV 386
>NP_001269659
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVGVGS 6
           EVG+GS
Sbjct: 220 EVGIGS 225
>NP_055675
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVGVGS 6
           EVG+GS
Sbjct: 222 EVGIGS 227
>NP_001269661
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  EVGVGS 6
          EVG+GS
Sbjct: 87 EVGIGS 92
>NP_001269660
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVGVGS 6
           EVG+GS
Sbjct: 220 EVGIGS 225
>NP_001269658
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVGVGS 6
           EVG+GS
Sbjct: 222 EVGIGS 227
>NP_653292
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EVGVGSSRV 9
          E GVG+ R+
Sbjct: 16 EAGVGAGRL 24
>XP_005248384
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
>XP_005248383
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VGVGSSRV 9
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
>XP_005264729
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EVGVGS 6
           EVG+GS
Sbjct: 220 EVGIGS 225
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.129    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 468,672
Number of extensions: 714
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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