Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     509
NP_036462                                                              20     509
NP_001243397                                                           20     509
NP_001092882                                                           20     509
NP_006757                                                              20     509
NP_001092883                                                           20     509
XP_005269721                                                           20     509
XP_005273706                                                           20     509
NP_001964                                                              17    4312
XP_005245008                                                           17    4312
XP_005245007                                                           17    4312
NP_068567                                                              17    4312
NP_001073901                                                           16    5631
NP_009029                                                              16    7355
NP_001269862                                                           16    7355
NP_116208                                                              16    7355
NP_001826                                                              16    7355
NP_001244027                                                           16    7355
NP_001239429                                                           16    7355
NP_001239428                                                           16    7355
NP_001244026                                                           16    7355
XP_006724391                                                           16    7355
XP_005261338                                                           16    7355
XP_005277858                                                           16    7355
XP_006724390                                                           16    7355
XP_006724389                                                           16    7355
XP_005277857                                                           16    7355
NP_001004334                                                           15    9605
NP_001138502                                                           15    9605
NP_001103132                                                           15    9605

>NP_001243398
          Length = 1781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1248 ETVQAVQSL 1256



>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1540 ETVQAVQSL 1548



>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1357 ETVQAVQSL 1365



>NP_001092882
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1423 ETVQAVQSL 1431



>NP_006757
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1423 ETVQAVQSL 1431



>NP_001092883
          Length = 2004

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1423 ETVQAVQSL 1431



>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1540 ETVQAVQSL 1548



>XP_005273706
          Length = 1997

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETVQAIQSL 9
            ETVQA+QSL
Sbjct: 1416 ETVQAVQSL 1424



>NP_001964
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETVQAIQSL 9
           ET+QA+++L
Sbjct: 220 ETIQALETL 228



>XP_005245008
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETVQAIQSL 9
           ET+QA+++L
Sbjct: 220 ETIQALETL 228



>XP_005245007
          Length = 431

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETVQAIQSL 9
           ET+QA+++L
Sbjct: 220 ETIQALETL 228



>NP_068567
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETVQAIQSL 9
           ET+QA+++L
Sbjct: 220 ETIQALETL 228



>NP_001073901
          Length = 505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETVQAIQSL 9
           ET+QA++ L
Sbjct: 149 ETIQALEEL 157



>NP_009029
          Length = 1640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 396 ETVQKFQSI 404



>NP_001269862
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ETVQAIQSL 9
          +TV A+QSL
Sbjct: 15 QTVLAVQSL 23



>NP_116208
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ETVQAIQSL 9
          +TV A+QSL
Sbjct: 15 QTVLAVQSL 23



>NP_001826
          Length = 1583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 396 ETVQKFQSI 404



>NP_001244027
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TVQAIQSL 9
           +VQA+QSL
Sbjct: 141 SVQALQSL 148



>NP_001239429
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TVQAIQSL 9
           +VQA+QSL
Sbjct: 127 SVQALQSL 134



>NP_001239428
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TVQAIQSL 9
           +VQA+QSL
Sbjct: 141 SVQALQSL 148



>NP_001244026
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TVQAIQSL 9
           +VQA+QSL
Sbjct: 141 SVQALQSL 148



>XP_006724391
          Length = 1567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 417 ETVQKFQSI 425



>XP_005261338
          Length = 1570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 417 ETVQKFQSI 425



>XP_005277858
          Length = 1604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 417 ETVQKFQSI 425



>XP_006724390
          Length = 1623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 379 ETVQKFQSI 387



>XP_006724389
          Length = 1653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 417 ETVQKFQSI 425



>XP_005277857
          Length = 1661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETVQAIQSL 9
           ETVQ  QS+
Sbjct: 417 ETVQKFQSI 425



>NP_001004334
          Length = 2367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETVQAIQSL 9
            +TV+A+Q L
Sbjct: 1520 QTVKAVQKL 1528



>NP_001138502
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETVQAIQSL 9
           +TV+ +QSL
Sbjct: 149 QTVECLQSL 157



>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETVQAIQSL 9
            + VQA+QS+
Sbjct: 2106 KVVQAVQSM 2114



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.115    0.253 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 250,476
Number of extensions: 361
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)