Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     229
NP_671714                                                              21     229
XP_006715890                                                           21     229
XP_005250160                                                           21     229
XP_005250159                                                           21     229
NP_004774                                                              18    1482
NP_001171134                                                           17    3301
NP_060621                                                              17    3301
NP_001171136                                                           17    3301
XP_006712674                                                           17    3301
XP_006712673                                                           17    3301
XP_006712672                                                           17    3301
XP_005246722                                                           17    3301
NP_001171135                                                           17    3301
NP_000436                                                              17    4312
NP_958780                                                              17    4312
NP_958781                                                              17    4312
NP_958785                                                              17    4312
NP_958783                                                              17    4312
NP_958786                                                              17    4312
NP_001779                                                              17    4312
NP_001229885                                                           17    4312
NP_001011553                                                           17    4312
NP_958782                                                              17    4312
NP_958784                                                              17    4312
NP_060729                                                              17    4312
XP_005253074                                                           17    4312
XP_006718326                                                           17    4312
XP_005253073                                                           17    4312
XP_006716654                                                           17    4312
XP_005251041                                                           17    4312
XP_005251040                                                           17    4312
XP_006716653                                                           17    4312
XP_006716652                                                           17    4312
XP_005251039                                                           17    4312
XP_005251038                                                           17    4312
XP_005251036                                                           17    4312
XP_005251037                                                           17    4312
XP_005251035                                                           17    4312
XP_006716651                                                           17    4312
XP_005251034                                                           17    4312
XP_005251033                                                           17    4312
XP_006715873                                                           17    4312
XP_006715872                                                           17    4312
XP_006715871                                                           17    4312
XP_006715870                                                           17    4312
XP_006715869                                                           17    4312
NP_543016                                                              16    5631
NP_079148                                                              16    5631
XP_005266042                                                           16    5631
XP_005266041                                                           16    5631
NP_071351                                                              16    7355
NP_065842                                                              16    7355
NP_001155059                                                           16    7355
NP_002094                                                              16    7355
NP_079418                                                              16    7355
NP_001139395                                                           16    7355
NP_065894                                                              16    7355
XP_005254476                                                           16    7355
XP_005254474                                                           16    7355
NP_003867                                                              16    7355
NP_004554                                                              15    9605
NP_001264243                                                           15    9605
NP_001137359                                                           15    9605
NP_001264242                                                           15    9605
NP_004227                                                              15    9605
XP_006723846                                                           15    9605
XP_006722543                                                           15    9605
XP_006720221                                                           15    9605
XP_006720220                                                           15    9605
NP_689683                                                              15    9605
NP_001004703                                                           15    9605
NP_001157903                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETTLEAQHK 9
            ETTL+AQHK
Sbjct: 3176 ETTLKAQHK 3184
>NP_671714
          Length = 3899

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETTLEAQHK 9
            ETTL+AQHK
Sbjct: 3168 ETTLKAQHK 3176
>XP_006715890
          Length = 3860

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETTLEAQHK 9
            ETTL+AQHK
Sbjct: 3129 ETTLKAQHK 3137
>XP_005250160
          Length = 3939

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETTLEAQHK 9
            ETTL+AQHK
Sbjct: 3208 ETTLKAQHK 3216
>XP_005250159
          Length = 3952

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETTLEAQHK 9
            ETTL+AQHK
Sbjct: 3221 ETTLKAQHK 3229
>NP_004774
          Length = 1049

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ETTLEAQHK 9
           ETT +AQHK
Sbjct: 774 ETTPKAQHK 782
>NP_001171134
          Length = 2446

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1715 TLECQHK 1721
>NP_060621
          Length = 2472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1715 TLECQHK 1721
>NP_001171136
          Length = 2446

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1715 TLECQHK 1721
>XP_006712674
          Length = 2436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1679 TLECQHK 1685
>XP_006712673
          Length = 2441

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1684 TLECQHK 1690
>XP_006712672
          Length = 2443

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1686 TLECQHK 1692
>XP_005246722
          Length = 2472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1715 TLECQHK 1721
>NP_001171135
          Length = 2446

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    TLEAQHK 9
            TLE QHK
Sbjct: 1715 TLECQHK 1721
>NP_000436
          Length = 4574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 897 TRLEAQHQ 904
>NP_958780
          Length = 4533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 856 TRLEAQHQ 863
>NP_958781
          Length = 4525

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 848 TRLEAQHQ 855
>NP_958785
          Length = 4551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 874 TRLEAQHQ 881
>NP_958783
          Length = 4515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 838 TRLEAQHQ 845
>NP_958786
          Length = 4547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 870 TRLEAQHQ 877
>NP_001779
          Length = 437

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 390 LEAQHK 395
>NP_001229885
          Length = 401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 354 LEAQHK 359
>NP_001011553
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 389 LEAQHK 394
>NP_958782
          Length = 4684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTLEAQHK 9
            T LEAQH+
Sbjct: 1007 TRLEAQHQ 1014
>NP_958784
          Length = 4547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 870 TRLEAQHQ 877
>NP_060729
          Length = 1141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E  LEAQH+
Sbjct: 345 EQKLEAQHR 353
>XP_005253074
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E  LEAQH+
Sbjct: 345 EQKLEAQHR 353
>XP_006718326
          Length = 968

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E  LEAQH+
Sbjct: 115 EQKLEAQHR 123
>XP_005253073
          Length = 1198

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E  LEAQH+
Sbjct: 345 EQKLEAQHR 353
>XP_006716654
          Length = 3562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTLEAQHK 9
            T LEAQH+
Sbjct: 1012 TRLEAQHQ 1019
>XP_005251041
          Length = 4520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 843 TRLEAQHQ 850
>XP_005251040
          Length = 4524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 847 TRLEAQHQ 854
>XP_006716653
          Length = 4529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 852 TRLEAQHQ 859
>XP_006716652
          Length = 4529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 852 TRLEAQHQ 859
>XP_005251039
          Length = 4530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 853 TRLEAQHQ 860
>XP_005251038
          Length = 4538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 861 TRLEAQHQ 868
>XP_005251036
          Length = 4552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 875 TRLEAQHQ 882
>XP_005251037
          Length = 4552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 875 TRLEAQHQ 882
>XP_005251035
          Length = 4556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 879 TRLEAQHQ 886
>XP_006716651
          Length = 4579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTLEAQHK 9
           T LEAQH+
Sbjct: 902 TRLEAQHQ 909
>XP_005251034
          Length = 4685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTLEAQHK 9
            T LEAQH+
Sbjct: 1008 TRLEAQHQ 1015
>XP_005251033
          Length = 4689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTLEAQHK 9
            T LEAQH+
Sbjct: 1012 TRLEAQHQ 1019
>XP_006715873
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 380 LEAQHK 385
>XP_006715872
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 398 LEAQHK 403
>XP_006715871
          Length = 446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 399 LEAQHK 404
>XP_006715870
          Length = 447

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 400 LEAQHK 405
>XP_006715869
          Length = 448

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQHK
Sbjct: 401 LEAQHK 406
>NP_543016
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTLEAQH 8
           TTL AQH
Sbjct: 378 TTLAAQH 384
>NP_079148
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETTLEAQHK 9
           ++TLEAQ++
Sbjct: 446 DSTLEAQYR 454
>XP_005266042
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETTLEAQHK 9
           ++TLEAQ++
Sbjct: 390 DSTLEAQYR 398
>XP_005266041
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ETTLEAQHK 9
           ++TLEAQ++
Sbjct: 390 DSTLEAQYR 398
>NP_071351
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TLEAQHK 9
          +LEAQH+
Sbjct: 83 SLEAQHR 89
>NP_065842
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETTLEAQHK 9
           ETT +++HK
Sbjct: 746 ETTPKSEHK 754
>NP_001155059
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TTLEAQH 8
           T +EAQH
Sbjct: 198 TAIEAQH 204
>NP_002094
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TTLEAQH 8
           T +EAQH
Sbjct: 262 TAIEAQH 268
>NP_079418
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETTLEAQHK 9
           ETT +++HK
Sbjct: 598 ETTPKSEHK 606
>NP_001139395
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLEAQHK 9
           TLEAQ+K
Sbjct: 385 TLEAQNK 391
>NP_065894
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLEAQHK 9
           TLEAQ+K
Sbjct: 631 TLEAQNK 637
>XP_005254476
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLEAQHK 9
           TLEAQ+K
Sbjct: 631 TLEAQNK 637
>XP_005254474
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLEAQHK 9
           TLEAQ+K
Sbjct: 637 TLEAQNK 643
>NP_003867
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ETTLEAQHK 9
          E  LEAQ+K
Sbjct: 50 EQALEAQYK 58
>NP_004554
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E+T  A+HK
Sbjct: 481 ESTAAAEHK 489
>NP_001264243
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           +TT E QH+
Sbjct: 611 KTTAEPQHQ 619
>NP_001137359
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ETTLEA 6
           ETTLEA
Sbjct: 140 ETTLEA 145
>NP_001264242
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           +TT E QH+
Sbjct: 611 KTTAEPQHQ 619
>NP_004227
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ETTLEA 6
           ETTLEA
Sbjct: 133 ETTLEA 138
>XP_006723846
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           ++ LEA HK
Sbjct: 326 DSLLEADHK 334
>XP_006722543
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQH+
Sbjct: 137 LEAQHR 142
>XP_006720221
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E+T  A+HK
Sbjct: 481 ESTAAAEHK 489
>XP_006720220
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           E+T  A+HK
Sbjct: 347 ESTAAAEHK 355
>NP_689683
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LEAQHK 9
           LEAQH+
Sbjct: 114 LEAQHR 119
>NP_001004703
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TLEAQHK 9
           +LEA+HK
Sbjct: 227 SLEARHK 233
>NP_001157903
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ETTLEAQHK 9
           ++ LEA HK
Sbjct: 325 DSLLEADHK 333
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.107    0.269 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 508,254
Number of extensions: 799
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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