Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     390
XP_005262424                                                           20     390
NP_597719                                                              17    4312
NP_001275511                                                           17    4312
XP_006713569                                                           17    4312
NP_056023                                                              16    5631
NP_001190985                                                           16    5631
NP_001077094                                                           16    5631
XP_006722380                                                           16    5631
XP_005258153                                                           16    5631
XP_005258152                                                           16    5631
XP_005258151                                                           16    5631
XP_005258150                                                           16    5631
XP_005258149                                                           16    5631
XP_006719294                                                           16    5631
NP_001138947                                                           16    5631
NP_059129                                                              16    7355
NP_872301                                                              16    7355
XP_006718829                                                           16    7355
NP_003391                                                              15    9605
NP_060656                                                              15    9605
NP_005025                                                              15    9605
NP_001165783                                                           15    9605
NP_002661                                                              15    9605
NP_001138791                                                           15    9605
NP_443117                                                              15    9605
NP_940931                                                              15    9605
NP_001138525                                                           15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_006713725                                                           15    9605
XP_006713724                                                           15    9605
XP_006713723                                                           15    9605
XP_006712159                                                           15    9605
XP_006712158                                                           15    9605
XP_005264603                                                           15    9605
XP_005264601                                                           15    9605
XP_006712157                                                           15    9605
XP_005245376                                                           15    9605
XP_005245374                                                           15    9605
NP_659411                                                              15    9605
>NP_722576
          Length = 3080

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETQIKSKDI 9
            ETQIKS+DI
Sbjct: 2290 ETQIKSRDI 2298
>XP_005262424
          Length = 2875

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETQIKSKDI 9
            ETQIKS+DI
Sbjct: 2085 ETQIKSRDI 2093
>NP_597719
          Length = 770

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETQIKSKD 8
           +TQIK KD
Sbjct: 568 KTQIKEKD 575
>NP_001275511
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETQIKSKD 8
           +TQIK KD
Sbjct: 568 KTQIKEKD 575
>XP_006713569
          Length = 341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETQIKSKD 8
           +TQIK KD
Sbjct: 139 KTQIKEKD 146
>NP_056023
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 826 SQIKEKDI 833
>NP_001190985
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 803 SQIKEKDI 810
>NP_001077094
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 803 SQIKEKDI 810
>XP_006722380
          Length = 1769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 533 SQIKEKDI 540
>XP_005258153
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 801 SQIKEKDI 808
>XP_005258152
          Length = 2060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 824 SQIKEKDI 831
>XP_005258151
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 826 SQIKEKDI 833
>XP_005258150
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 826 SQIKEKDI 833
>XP_005258149
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           +QIK KDI
Sbjct: 826 SQIKEKDI 833
>XP_006719294
          Length = 2348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETQIKSKD 8
           E QIK+KD
Sbjct: 979 ERQIKTKD 986
>NP_001138947
          Length = 2351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETQIKSKD 8
           E QIK+KD
Sbjct: 979 ERQIKTKD 986
>NP_059129
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           TQI+ KD+
Sbjct: 288 TQIEGKDV 295
>NP_872301
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ETQIKSKDI 9
          ET+++ KDI
Sbjct: 79 ETELRIKDI 87
>XP_006718829
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ETQIKSKDI 9
          ET+++ KDI
Sbjct: 73 ETELRIKDI 81
>NP_003391
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           TQ+KSK +
Sbjct: 187 TQVKSKHL 194
>NP_060656
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETQIKSKDI 9
           ++Q+K KDI
Sbjct: 198 KSQLKHKDI 206
>NP_005025
          Length = 58

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ETQIKSKD 8
          E +IKS+D
Sbjct: 25 ENEIKSRD 32
>NP_001165783
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>NP_002661
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>NP_001138791
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>NP_443117
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETQIKSKDI 9
           ET+ K++DI
Sbjct: 486 ETKFKTEDI 494
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETQIKSK 7
           ET++KSK
Sbjct: 103 ETELKSK 109
>NP_001138525
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ETQIKSK 7
          ET++KSK
Sbjct: 47 ETELKSK 53
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETQIKSK 7
           ET++KSK
Sbjct: 103 ETELKSK 109
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETQIKSK 7
           ET++KSK
Sbjct: 103 ETELKSK 109
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ETQIKSK 7
           ET++KSK
Sbjct: 103 ETELKSK 109
>XP_006713725
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>XP_006713724
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>XP_006713723
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QIKSKDI 9
          ++KSKDI
Sbjct: 82 ELKSKDI 88
>XP_006712159
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TQIKSKDI 9
          TQ+KSK +
Sbjct: 20 TQVKSKHL 27
>XP_006712158
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TQIKSKDI 9
          TQ+KSK +
Sbjct: 20 TQVKSKHL 27
>XP_005264603
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TQIKSKDI 9
          TQ+KSK +
Sbjct: 56 TQVKSKHL 63
>XP_005264601
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           TQ+KSK +
Sbjct: 172 TQVKSKHL 179
>XP_006712157
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TQIKSKDI 9
           TQ+KSK +
Sbjct: 187 TQVKSKHL 194
>XP_005245376
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ETQIKSKDI 9
          ++Q+K KDI
Sbjct: 63 KSQLKHKDI 71
>XP_005245374
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ETQIKSKDI 9
           ++Q+K KDI
Sbjct: 256 KSQLKHKDI 264
>NP_659411
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ETQIKS 6
          ETQIKS
Sbjct: 94 ETQIKS 99
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.119    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 469,185
Number of extensions: 799
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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