Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              22     103
XP_006718908                                                           22     103
XP_005271621                                                           22     103
XP_006718907                                                           22     103
XP_006718906                                                           22     103
XP_005271619                                                           22     103
XP_005271618                                                           22     103
NP_004949                                                              20     390
XP_005263496                                                           20     390
XP_005263495                                                           20     390
NP_008835                                                              19     869
NP_001075109                                                           19     869
XP_005249801                                                           18    1482
NP_861456                                                              18    1482
NP_001175                                                              18    1935
NP_055907                                                              17    2528
XP_005255242                                                           17    2528
XP_005255241                                                           17    2528
XP_005255240                                                           17    2528
XP_005255239                                                           17    2528
NP_115892                                                              17    3301
NP_001035269                                                           17    3301
NP_001035706                                                           17    4312
NP_037522                                                              17    4312
NP_001129292                                                           17    4312
XP_005255000                                                           17    4312
XP_005254998                                                           17    4312
XP_005251926                                                           17    4312
NP_001231509                                                           16    5631
NP_003487                                                              16    5631
NP_001888                                                              16    5631
NP_068781                                                              16    7355
NP_061722                                                              16    7355
NP_001153218                                                           16    7355
NP_001269078                                                           16    7355
NP_001083                                                              16    7355
XP_006725360                                                           16    7355
XP_006725359                                                           16    7355
XP_006725358                                                           16    7355
XP_006725357                                                           16    7355
XP_006725356                                                           16    7355
XP_006725355                                                           16    7355
XP_006721575                                                           16    7355
XP_006721574                                                           16    7355
XP_006721573                                                           16    7355
XP_006721572                                                           16    7355
XP_006721571                                                           16    7355
XP_006721570                                                           16    7355
XP_006721569                                                           16    7355
NP_114089                                                              16    7355
NP_536350                                                              15    9605
NP_002556                                                              15    9605
NP_689603                                                              15    9605
NP_004236                                                              15    9605
NP_963925                                                              15    9605
XP_005264201                                                           15    9605
>NP_000042
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2904 ETVPFRLTR 2912
>XP_006718908
          Length = 1708

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 1556 ETVPFRLTR 1564
>XP_005271621
          Length = 2708

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2556 ETVPFRLTR 2564
>XP_006718907
          Length = 3050

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2898 ETVPFRLTR 2906
>XP_006718906
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2904 ETVPFRLTR 2912
>XP_005271619
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2904 ETVPFRLTR 2912
>XP_005271618
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ETIPFRLTR 9
            ET+PFRLTR
Sbjct: 2904 ETVPFRLTR 2912
>NP_004949
          Length = 2549

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E IPFRLTR
Sbjct: 2373 EKIPFRLTR 2381
>XP_005263496
          Length = 2322

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E IPFRLTR
Sbjct: 2146 EKIPFRLTR 2154
>XP_005263495
          Length = 2549

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E IPFRLTR
Sbjct: 2373 EKIPFRLTR 2381
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFRLTR
Sbjct: 3957 ELMPFRLTR 3965
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFRLTR
Sbjct: 3926 ELMPFRLTR 3934
>XP_005249801
          Length = 324

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  TIPFRLT 8
          T+PFRLT
Sbjct: 87 TVPFRLT 93
>NP_861456
          Length = 305

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  TIPFRLT 8
          T+PFRLT
Sbjct: 68 TVPFRLT 74
>NP_001175
          Length = 2644

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ETIPFRLT 8
            E +PFRLT
Sbjct: 2509 EIVPFRLT 2516
>NP_055907
          Length = 3661

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFR+T+
Sbjct: 2369 EKVPFRMTQ 2377
>XP_005255242
          Length = 3609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFR+T+
Sbjct: 2317 EKVPFRMTQ 2325
>XP_005255241
          Length = 3637

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFR+T+
Sbjct: 2345 EKVPFRMTQ 2353
>XP_005255240
          Length = 3663

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFR+T+
Sbjct: 2371 EKVPFRMTQ 2379
>XP_005255239
          Length = 3689

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    ETIPFRLTR 9
            E +PFR+T+
Sbjct: 2397 EKVPFRMTQ 2405
>NP_115892
          Length = 340

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PFRLTR 9
           PFRLTR
Sbjct: 138 PFRLTR 143
>NP_001035269
          Length = 340

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PFRLTR 9
           PFRLTR
Sbjct: 138 PFRLTR 143
>NP_001035706
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETIPFRLT 8
           +TIP RLT
Sbjct: 571 QTIPHRLT 578
>NP_037522
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TIPFRLT 8
            ++PFRLT
Sbjct: 1254 SVPFRLT 1260
>NP_001129292
          Length = 1320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TIPFRLT 8
            ++PFRLT
Sbjct: 1191 SVPFRLT 1197
>XP_005255000
          Length = 721

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETIPFRLT 8
           +TIP RLT
Sbjct: 535 QTIPHRLT 542
>XP_005254998
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ETIPFRLT 8
           +TIP RLT
Sbjct: 571 QTIPHRLT 578
>XP_005251926
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TIPFRLT 8
            ++PFRLT
Sbjct: 1254 SVPFRLT 1260
>NP_001231509
          Length = 3859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    IPFRLT 8
            +PFRLT
Sbjct: 3727 VPFRLT 3732
>NP_003487
          Length = 3830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    IPFRLT 8
            +PFRLT
Sbjct: 3698 VPFRLT 3703
>NP_001888
          Length = 2322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TIPFRLTR 9
            ++P RLTR
Sbjct: 1838 SVPLRLTR 1845
>NP_068781
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 424 TIPFRI 429
>NP_061722
          Length = 1007

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           T+PFRL
Sbjct: 407 TLPFRL 412
>NP_001153218
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 378 TIPFRI 383
>NP_001269078
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 206 TIPFRI 211
>NP_001083
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 387 TIPFRI 392
>XP_006725360
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 334 TIPFRI 339
>XP_006725359
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 378 TIPFRI 383
>XP_006725358
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 378 TIPFRI 383
>XP_006725357
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 387 TIPFRI 392
>XP_006725356
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 424 TIPFRI 429
>XP_006725355
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 436 TIPFRI 441
>XP_006721575
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 334 TIPFRI 339
>XP_006721574
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 378 TIPFRI 383
>XP_006721573
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 378 TIPFRI 383
>XP_006721572
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 387 TIPFRI 392
>XP_006721571
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 424 TIPFRI 429
>XP_006721570
          Length = 1118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 683 TIPFRI 688
>XP_006721569
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           TIPFR+
Sbjct: 683 TIPFRI 688
>NP_114089
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   TIPFRL 7
           T+PFRL
Sbjct: 407 TLPFRL 412
>NP_536350
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ETIPFRL 7
           ET+PF L
Sbjct: 222 ETMPFEL 228
>NP_002556
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IPFRLTR 9
           +PF +TR
Sbjct: 259 VPFHITR 265
>NP_689603
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IPFRLTR 9
           IPF LT+
Sbjct: 155 IPFNLTK 161
>NP_004236
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ETIPFR 6
           ET+PF+
Sbjct: 603 ETVPFK 608
>NP_963925
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ETIPFR 6
           ET+PF+
Sbjct: 685 ETVPFK 690
>XP_005264201
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IPFRLTR 9
           IPF LT+
Sbjct: 155 IPFNLTK 161
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.147    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,762
Number of extensions: 708
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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