Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     509
NP_066124                                                              20     509
XP_006717999                                                           20     509
NP_000867                                                              18    1935
XP_006723678                                                           17    3301
NP_003236                                                              17    3301
NP_001182474                                                           17    4312
NP_612143                                                              17    4312
NP_001157790                                                           16    5631
NP_001157791                                                           16    5631
NP_001157789                                                           16    5631
NP_001448                                                              16    5631
NP_775864                                                              16    5631
XP_006713130                                                           16    5631
XP_005265035                                                           16    5631
XP_005265034                                                           16    5631
NP_002213                                                              16    7355
NP_001003712                                                           16    7355
NP_001093422                                                           16    7355
NP_001161744                                                           16    7355
NP_065892                                                              16    7355
NP_004557                                                              16    7355
NP_001138915                                                           16    7355
NP_001269559                                                           16    7355
NP_001121620                                                           16    7355
XP_005268680                                                           16    7355
XP_006719287                                                           16    7355
XP_005268679                                                           16    7355
XP_005268678                                                           16    7355
XP_006719286                                                           16    7355
XP_006719285                                                           16    7355
XP_005252521                                                           16    7355
XP_005252520                                                           16    7355
XP_006713199                                                           16    7355
XP_006713198                                                           16    7355
XP_006713197                                                           16    7355
XP_005265167                                                           16    7355
XP_006713196                                                           16    7355
XP_006713195                                                           16    7355
XP_005265166                                                           16    7355
XP_006713194                                                           16    7355
NP_003225                                                              16    7355
NP_004973                                                              15    9605
NP_862828                                                              15    9605
NP_001604                                                              15    9605
NP_001135417                                                           15    9605
NP_005150                                                              15    9605
NP_001091                                                              15    9605
NP_001092                                                              15    9605
NP_001186883                                                           15    9605
NP_115575                                                              15    9605
NP_001231567                                                           15    9605
NP_001605                                                              15    9605
NP_056189                                                              15    9605
NP_001186509                                                           15    9605
NP_008892                                                              15    9605
NP_001186508                                                           15    9605
XP_005261558                                                           15    9605
XP_005261557                                                           15    9605
XP_005258844                                                           15    9605
XP_006723221                                                           15    9605
XP_005258843                                                           15    9605
XP_005258842                                                           15    9605
XP_005258841                                                           15    9605
XP_006722112                                                           15    9605
XP_006722111                                                           15    9605
XP_005253415                                                           15    9605
NP_001606                                                              15    9605
>NP_065681
          Length = 1072

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SYVAEEAG 9
           SYVAEEAG
Sbjct: 507 SYVAEEAG 514
>NP_066124
          Length = 1114

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SYVAEEAG 9
           SYVAEEAG
Sbjct: 507 SYVAEEAG 514
>XP_006717999
          Length = 1207

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SYVAEEAG 9
           SYVAEEAG
Sbjct: 600 SYVAEEAG 607
>NP_000867
          Length = 2491

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SYVAEEAG 9
           SYV EEAG
Sbjct: 263 SYVREEAG 270
>XP_006723678
          Length = 718

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           E YV E+AG
Sbjct: 178 EEYVQEDAG 186
>NP_003236
          Length = 693

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           E YV E+AG
Sbjct: 153 EEYVQEDAG 161
>NP_001182474
          Length = 275

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  YVAEEAG 9
          YVA+EAG
Sbjct: 53 YVAKEAG 59
>NP_612143
          Length = 645

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SY+ EE G
Sbjct: 224 KSYICEECG 232
>NP_001157790
          Length = 2591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2240 SYIAQEPG 2247
>NP_001157791
          Length = 2578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2227 SYIAQEPG 2234
>NP_001157789
          Length = 2633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2282 SYIAQEPG 2289
>NP_001448
          Length = 2602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2251 SYIAQEPG 2258
>NP_775864
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESYVAEE 7
           ESY+AE+
Sbjct: 566 ESYIAEQ 572
>XP_006713130
          Length = 2109

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 1758 SYIAQEPG 1765
>XP_005265035
          Length = 2609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2258 SYIAQEPG 2265
>XP_005265034
          Length = 2622

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SYVAEEAG 9
            SY+A+E G
Sbjct: 2271 SYIAQEPG 2278
>NP_002213
          Length = 2695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2605 ESYVAE 2610
>NP_001003712
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 663 EKYVLEEA 670
>NP_001093422
          Length = 2710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2620 ESYVAE 2625
>NP_001161744
          Length = 2743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2653 ESYVAE 2658
>NP_065892
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 705 EKYVLEEA 712
>NP_004557
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ESYVAEEAG 9
           +SY+A+E G
Sbjct: 111 KSYLAKEGG 119
>NP_001138915
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ESYVAEEAG 9
          +SY+A+E G
Sbjct: 91 KSYLAKEGG 99
>NP_001269559
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ESYVAEEAG 9
           +SY+A+E G
Sbjct: 125 KSYLAKEGG 133
>NP_001121620
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SYVAEEAG 9
           SYV  EAG
Sbjct: 151 SYVPREAG 158
>XP_005268680
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 663 EKYVLEEA 670
>XP_006719287
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 663 EKYVLEEA 670
>XP_005268679
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 702 EKYVLEEA 709
>XP_005268678
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 705 EKYVLEEA 712
>XP_006719286
          Length = 909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 725 EKYVLEEA 732
>XP_006719285
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ESYVAEEA 8
           E YV EEA
Sbjct: 728 EKYVLEEA 735
>XP_005252521
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ESYVAEEAG 9
           +SY+A+E G
Sbjct: 111 KSYLAKEGG 119
>XP_005252520
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ESYVAEEAG 9
           +SY+A+E G
Sbjct: 111 KSYLAKEGG 119
>XP_006713199
          Length = 2695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2605 ESYVAE 2610
>XP_006713198
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2609 ESYVAE 2614
>XP_006713197
          Length = 2712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2622 ESYVAE 2627
>XP_005265167
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2629 ESYVAE 2634
>XP_006713196
          Length = 2721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2631 ESYVAE 2636
>XP_006713195
          Length = 2727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2637 ESYVAE 2642
>XP_005265166
          Length = 2735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2645 ESYVAE 2650
>XP_006713194
          Length = 2736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ESYVAE 6
            ESYVAE
Sbjct: 2646 ESYVAE 2651
>NP_003225
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SYVAEEAG 9
           SYV  EAG
Sbjct: 151 SYVPREAG 158
>NP_004973
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SYVAEE 7
           SY+AEE
Sbjct: 312 SYIAEE 317
>NP_862828
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SYV +E G
Sbjct: 205 KSYVCKECG 213
>NP_001604
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 53 DSYVGDEA 60
>NP_001135417
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 53 DSYVGDEA 60
>NP_005150
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 53 DSYVGDEA 60
>NP_001091
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 53 DSYVGDEA 60
>NP_001092
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 51 DSYVGDEA 58
>NP_001186883
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 51 DSYVGDEA 58
>NP_115575
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VAEEAG 9
           VAEEAG
Sbjct: 529 VAEEAG 534
>NP_001231567
          Length = 945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VAEEAG 9
           VAEEAG
Sbjct: 286 VAEEAG 291
>NP_001605
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 51 DSYVGDEA 58
>NP_056189
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +S VAEE G
Sbjct: 432 QSSVAEEVG 440
>NP_001186509
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +S VAEE G
Sbjct: 432 QSSVAEEVG 440
>NP_008892
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SYVAEEAG 9
           SYV +E G
Sbjct: 384 SYVCDECG 391
>NP_001186508
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +S VAEE G
Sbjct: 453 QSSVAEEVG 461
>XP_005261558
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +S VAEE G
Sbjct: 432 QSSVAEEVG 440
>XP_005261557
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +S VAEE G
Sbjct: 467 QSSVAEEVG 475
>XP_005258844
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ESYVAEEAG 9
          +SYV +E G
Sbjct: 66 KSYVCKECG 74
>XP_006723221
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SYV +E G
Sbjct: 113 KSYVCKECG 121
>XP_005258843
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SYV +E G
Sbjct: 180 KSYVCKECG 188
>XP_005258842
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SYV +E G
Sbjct: 180 KSYVCKECG 188
>XP_005258841
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESYVAEEAG 9
           +SYV +E G
Sbjct: 180 KSYVCKECG 188
>XP_006722112
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ESYVAEEA 8
           +SYV +EA
Sbjct: 144 DSYVGDEA 151
>XP_006722111
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ESYVAEEA 8
           +SYV +EA
Sbjct: 144 DSYVGDEA 151
>XP_005253415
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SYVAEE 7
           SY+AEE
Sbjct: 312 SYIAEE 317
>NP_001606
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ESYVAEEA 8
          +SYV +EA
Sbjct: 52 DSYVGDEA 59
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.288    0.113    0.274 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 561,806
Number of extensions: 1833
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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