Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_078966                                                              17    3301
NP_891548                                                              16    7355
NP_001129627                                                           16    7355
NP_001129626                                                           16    7355
NP_001278320                                                           16    7355
NP_001230361                                                           16    7355
NP_001230357                                                           16    7355
NP_001473                                                              15    9605
XP_006721879                                                           15    9605
XP_006721878                                                           15    9605
XP_006721877                                                           15    9605
XP_006721876                                                           15    9605
XP_005257269                                                           15    9605
XP_006721875                                                           15    9605
XP_005257264                                                           15    9605
NP_056469                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ESTQRVTAS 9
           ES QRVTAS
Sbjct: 873 ESAQRVTAS 881
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ESTQRVTAS 9
           ES QRVTAS
Sbjct: 668 ESAQRVTAS 676
>NP_078966
          Length = 14507

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    STQRVTAS 9
            STQRVT S
Sbjct: 1172 STQRVTTS 1179
>NP_891548
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 239 EATQRIT 245
>NP_001129627
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 147 EATQRIT 153
>NP_001129626
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 246 EATQRIT 252
>NP_001278320
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 246 EATQRIT 252
>NP_001230361
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 246 EATQRIT 252
>NP_001230357
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ESTQRVT 7
           E+TQR+T
Sbjct: 246 EATQRIT 252
>NP_001473
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          +STQ  TAS
Sbjct: 37 QSTQAATAS 45
>XP_006721879
          Length = 112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 34 EELQRLTAS 42
>XP_006721878
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 34 EELQRLTAS 42
>XP_006721877
          Length = 135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 35 EELQRLTAS 43
>XP_006721876
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 4  EELQRLTAS 12
>XP_005257269
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 4  EELQRLTAS 12
>XP_006721875
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 34 EELQRLTAS 42
>XP_005257264
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 34 EELQRLTAS 42
>NP_056469
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ESTQRVTAS 9
          E  QR+TAS
Sbjct: 35 EELQRLTAS 43
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.286   0.0934    0.201 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 279,029
Number of extensions: 351
Number of successful extensions: 18
Number of sequences better than 10000.0: 18
Number of HSP's gapped: 18
Number of HSP's successfully gapped: 18
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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