Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     299
XP_006713721                                                           20     299
XP_006723106                                                           18    1935
XP_006723105                                                           18    1935
NP_604393                                                              18    1935
XP_005262424                                                           17    4312
NP_054815                                                              16    5631
NP_001265135                                                           16    5631
NP_001265130                                                           16    5631
NP_060081                                                              16    5631
NP_955361                                                              16    5631
NP_001005198                                                           16    7355
NP_001074924                                                           16    7355
NP_001160006                                                           16    7355
NP_001160005                                                           16    7355
XP_005248604                                                           16    7355
XP_005248602                                                           16    7355
XP_006713895                                                           16    7355
XP_005247980                                                           16    7355
XP_005247979                                                           16    7355
XP_005247978                                                           16    7355
NP_001136021                                                           16    7355
NP_077726                                                              16    7355
NP_055694                                                              16    7355
NP_036474                                                              16    7355
NP_001243506                                                           15    9605
NP_001159864                                                           15    9605
NP_078930                                                              15    9605
NP_789787                                                              15    9605
NP_689860                                                              15    9605
NP_006661                                                              15    9605
XP_005254277                                                           15    9605
XP_005254276                                                           15    9605
XP_005254275                                                           15    9605
XP_006720491                                                           15    9605
XP_006720490                                                           15    9605
XP_006720489                                                           15    9605
XP_006720488                                                           15    9605
XP_005254273                                                           15    9605
XP_006720487                                                           15    9605
XP_005254272                                                           15    9605
XP_006720486                                                           15    9605
XP_005254271                                                           15    9605
XP_005254270                                                           15    9605
XP_005248820                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  ESSYIFISV 9
          ESSYIF+SV
Sbjct: 65 ESSYIFVSV 73
>XP_006713721
          Length = 1068

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  ESSYIFISV 9
          ESSYIF+SV
Sbjct: 65 ESSYIFVSV 73
>XP_006723106
          Length = 971

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ESSY+F+ V
Sbjct: 479 ESSYVFLHV 487
>XP_006723105
          Length = 1028

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ESSY+F+ V
Sbjct: 479 ESSYVFLHV 487
>NP_604393
          Length = 994

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ESSY+F+ V
Sbjct: 445 ESSYVFLHV 453
>XP_005262424
          Length = 2875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SSYIFISV 9
          SS+IF+SV
Sbjct: 17 SSFIFLSV 24
>NP_054815
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           +S+IFISV
Sbjct: 188 ASFIFISV 195
>NP_001265135
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           +S+IFISV
Sbjct: 201 ASFIFISV 208
>NP_001265130
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           +S+IFISV
Sbjct: 188 ASFIFISV 195
>NP_060081
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           +S+IFISV
Sbjct: 188 ASFIFISV 195
>NP_955361
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           +S+IFISV
Sbjct: 188 ASFIFISV 195
>NP_001005198
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   SSYIFI 7
           SSYIFI
Sbjct: 251 SSYIFI 256
>NP_001074924
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>NP_001160006
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 348 KSNYLFVAV 356
>NP_001160005
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 477 KSNYLFVAV 485
>XP_005248604
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 439 KSNYLFVAV 447
>XP_005248602
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 473 KSNYLFVAV 481
>XP_006713895
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>XP_005247980
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>XP_005247979
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>XP_005247978
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>NP_001136021
          Length = 690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 463 KSNYLFVAV 471
>NP_077726
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ESSYIFISV 9
           +S+Y+F++V
Sbjct: 497 KSNYLFVAV 505
>NP_055694
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   SSYIFISV 9
           S+YIF+++
Sbjct: 187 SNYIFVAI 194
>NP_036474
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SSYIFI 7
          SSYIFI
Sbjct: 5  SSYIFI 10
>NP_001243506
          Length = 216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SSYIFIS 8
           S+Y+F+S
Sbjct: 180 STYVFVS 186
>NP_001159864
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ++SY+F+ +
Sbjct: 353 QTSYVFLGI 361
>NP_078930
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSYIFI 7
           SSYIF+
Sbjct: 241 SSYIFV 246
>NP_789787
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SSYIFISV 9
          S+++FISV
Sbjct: 16 STFLFISV 23
>NP_689860
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>NP_006661
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ++SY+F+ +
Sbjct: 353 QTSYVFLGI 361
>XP_005254277
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254276
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254275
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 135 ESSYLF 140
>XP_006720491
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 169 ESSYLF 174
>XP_006720490
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 186 ESSYLF 191
>XP_006720489
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 222 ESSYLF 227
>XP_006720488
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254273
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 235 ESSYLF 240
>XP_006720487
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254272
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 257 ESSYLF 262
>XP_006720486
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254271
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005254270
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ESSYIF 6
           ESSY+F
Sbjct: 269 ESSYLF 274
>XP_005248820
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   ESSYIFISV 9
           ++SY+F+ +
Sbjct: 353 QTSYVFLGI 361
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.134    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 398,235
Number of extensions: 507
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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