Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_001431                                                              17    3301
XP_006716365                                                           17    3301
NP_065979                                                              17    4312
NP_001073932                                                           17    4312
NP_001368                                                              17    4312
NP_006608                                                              17    4312
NP_612392                                                              17    4312
NP_006176                                                              17    4312
NP_002694                                                              17    4312
NP_001273490                                                           17    4312
XP_005256293                                                           17    4312
XP_006721399                                                           17    4312
XP_006721398                                                           17    4312
XP_006718966                                                           17    4312
XP_006718633                                                           17    4312
XP_006718632                                                           17    4312
XP_006718631                                                           17    4312
XP_006718630                                                           17    4312
XP_006718629                                                           17    4312
XP_006718628                                                           17    4312
XP_006718627                                                           17    4312
XP_006718626                                                           17    4312
XP_006718625                                                           17    4312
XP_006714727                                                           17    4312
NP_000490                                                              16    5631
NP_001129477                                                           16    5631
NP_001129478                                                           16    5631
NP_000810                                                              16    5631
NP_003761                                                              16    5631
XP_006724053                                                           16    5631
XP_006724052                                                           16    5631
XP_005260998                                                           16    5631
XP_006724051                                                           16    5631
XP_005254242                                                           16    5631
XP_005267824                                                           16    5631
XP_005252905                                                           16    5631
XP_005252904                                                           16    5631
NP_059133                                                              16    5631
NP_036326                                                              16    5631
NP_780294                                                              16    5631
NP_061184                                                              16    7355
NP_003326                                                              16    7355
NP_071928                                                              16    7355
XP_006714549                                                           16    7355
XP_006714548                                                           16    7355
XP_005248392                                                           16    7355
XP_005248393                                                           16    7355
XP_005248391                                                           16    7355
XP_005248390                                                           16    7355
XP_005265487                                                           16    7355
XP_006713384                                                           16    7355
NP_001138537                                                           15    9605
NP_055616                                                              15    9605
NP_000557                                                              15    9605
NP_001004340                                                           15    9605
NP_001017986                                                           15    9605
XP_005273744                                                           15    9605
XP_006716478                                                           15    9605
XP_005273329                                                           15    9605
XP_005245015                                                           15    9605
XP_005245014                                                           15    9605
NP_689485                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ESLISSLQE 9
            ESLISSLQ+
Sbjct: 1344 ESLISSLQQ 1352
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ESLISSLQE 9
            ESLISSLQ+
Sbjct: 1344 ESLISSLQQ 1352
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ESLISSLQE 9
            ESLISSLQ+
Sbjct: 1344 ESLISSLQQ 1352
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ESLISSLQE 9
            ESLISSLQ+
Sbjct: 1344 ESLISSLQQ 1352
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    ESLISSLQE 9
            ESLISSLQ+
Sbjct: 1344 ESLISSLQQ 1352
>NP_001431
          Length = 919

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESL SSLQE
Sbjct: 351 ESLRSSLQE 359
>XP_006716365
          Length = 919

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESL SSLQE
Sbjct: 351 ESLRSSLQE 359
>NP_065979
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           E LIS LQE
Sbjct: 720 EQLISKLQE 728
>NP_001073932
          Length = 4314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ESLISSLQ 8
            +SLISSLQ
Sbjct: 3552 QSLISSLQ 3559
>NP_001368
          Length = 4307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ESLISSLQ 8
            +SLISSLQ
Sbjct: 3545 QSLISSLQ 3552
>NP_006608
          Length = 1621

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + L+SSLQE
Sbjct: 654 QELVSSLQE 662
>NP_612392
          Length = 747

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESLI+ LQE
Sbjct: 101 ESLINPLQE 109
>NP_006176
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>NP_002694
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           E L+SS+QE
Sbjct: 463 EGLVSSVQE 471
>NP_001273490
          Length = 2101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_005256293
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESLI+ LQE
Sbjct: 101 ESLINPLQE 109
>XP_006721399
          Length = 719

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESLI+ LQE
Sbjct: 101 ESLINPLQE 109
>XP_006721398
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESLI+ LQE
Sbjct: 101 ESLINPLQE 109
>XP_006718966
          Length = 4300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    ESLISSLQ 8
            +SLISSLQ
Sbjct: 3538 QSLISSLQ 3545
>XP_006718633
          Length = 2101

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718632
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718631
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718630
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718629
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718628
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718627
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718626
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006718625
          Length = 2115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    SLISSLQE 9
            SLISSL+E
Sbjct: 1225 SLISSLEE 1232
>XP_006714727
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           E LIS LQE
Sbjct: 115 EQLISKLQE 123
>NP_000490
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           E LIS+LQE
Sbjct: 168 EVLISTLQE 176
>NP_001129477
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>NP_001129478
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>NP_000810
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>NP_003761
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           +SLIS+L+E
Sbjct: 363 QSLISNLEE 371
>XP_006724053
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>XP_006724052
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>XP_005260998
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>XP_006724051
          Length = 1026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 410 ENLISALEE 418
>XP_005254242
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           E LIS+LQE
Sbjct: 168 EVLISTLQE 176
>XP_005267824
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESLISSLQ 8
           +SL+SSLQ
Sbjct: 612 DSLVSSLQ 619
>XP_005252905
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ES+IS LQ+
Sbjct: 413 ESIISGLQQ 421
>XP_005252904
          Length = 1855

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ES+IS LQ+
Sbjct: 413 ESIISGLQQ 421
>NP_059133
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ESLISSLQ 8
           +SL+SSLQ
Sbjct: 612 DSLVSSLQ 619
>NP_036326
          Length = 1849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ES+IS LQ+
Sbjct: 413 ESIISGLQQ 421
>NP_780294
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ESLISSLQE 9
           E+LIS+L+E
Sbjct: 394 ENLISALEE 402
>NP_061184
          Length = 980

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           E L+S+LQE
Sbjct: 443 ELLVSALQE 451
>NP_003326
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESL++ LQE
Sbjct: 929 ESLLAHLQE 937
>NP_071928
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_006714549
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_006714548
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_005248392
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_005248393
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_005248391
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_005248390
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ESLISSL 7
          ESLISSL
Sbjct: 18 ESLISSL 24
>XP_005265487
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESL++ LQE
Sbjct: 904 ESLLAHLQE 912
>XP_006713384
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           ESL++ LQE
Sbjct: 922 ESLLAHLQE 930
>NP_001138537
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           + LIS LQE
Sbjct: 688 DELISQLQE 696
>NP_055616
          Length = 2137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ESLISSLQ 8
            ESL+ SLQ
Sbjct: 1554 ESLLKSLQ 1561
>NP_000557
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + +ISSLQE
Sbjct: 335 KKVISSLQE 343
>NP_001004340
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + +ISSLQE
Sbjct: 149 KKVISSLQE 157
>NP_001017986
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + +ISSLQE
Sbjct: 241 KKVISSLQE 249
>XP_005273744
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           ESL+  +QE
Sbjct: 235 ESLVDQIQE 243
>XP_006716478
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           ESL+  +QE
Sbjct: 345 ESLVDQIQE 353
>XP_005273329
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ESLISSLQ 8
            ESL+ SLQ
Sbjct: 1351 ESLLKSLQ 1358
>XP_005245015
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + +ISSLQE
Sbjct: 243 KKVISSLQE 251
>XP_005245014
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESLISSLQE 9
           + +ISSLQE
Sbjct: 336 KKVISSLQE 344
>NP_689485
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ESLISSLQE 9
           ESL+  +QE
Sbjct: 345 ESLVDQIQE 353
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.289    0.111    0.228 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 353,204
Number of extensions: 764
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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