Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           17    2528
NP_004561                                                              17    2528
NP_001275703                                                           17    2528
XP_005253450                                                           17    2528
XP_006719151                                                           17    2528
XP_005252905                                                           17    3301
XP_005252904                                                           17    3301
NP_036326                                                              17    3301
NP_001188267                                                           17    4312
NP_001188269                                                           17    4312
NP_002958                                                              17    4312
NP_001188268                                                           17    4312
NP_078858                                                              17    4312
NP_001278232                                                           17    4312
NP_001278214                                                           17    4312
NP_060376                                                              17    4312
NP_057664                                                              17    4312
NP_055464                                                              17    4312
XP_006722902                                                           17    4312
XP_006715192                                                           17    4312
XP_005249261                                                           17    4312
NP_061885                                                              16    5631
NP_001243716                                                           16    5631
NP_001243399                                                           16    5631
NP_001137293                                                           16    5631
XP_006719159                                                           16    5631
XP_006719157                                                           16    5631
XP_006719156                                                           16    5631
XP_006719155                                                           16    5631
XP_005253457                                                           16    5631
XP_006719154                                                           16    5631
XP_005253456                                                           16    5631
XP_005253455                                                           16    5631
XP_006719153                                                           16    5631
XP_006719152                                                           16    5631
NP_001136025                                                           16    7355
NP_001136024                                                           16    7355
NP_060109                                                              16    7355
NP_004217                                                              16    7355
NP_005236                                                              16    7355
XP_005270370                                                           16    7355
XP_006717680                                                           16    7355
XP_006714202                                                           16    7355
XP_005262892                                                           16    7355
XP_005262891                                                           16    7355
NP_001035194                                                           16    7355
NP_056471                                                              16    7355
NP_694579                                                              16    7355
NP_056485                                                              15    9605
NP_056164                                                              15    9605
NP_001073869                                                           15    9605
NP_071896                                                              15    9605
XP_006722933                                                           15    9605
XP_006722932                                                           15    9605
XP_006722931                                                           15    9605
XP_006722930                                                           15    9605
XP_005259697                                                           15    9605
XP_006722929                                                           15    9605
XP_005249030                                                           15    9605
XP_005249029                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ESGLLSTTR 9
            ES LLSTTR
Sbjct: 1236 ESCLLSTTR 1244
>NP_004561
          Length = 1445

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ESGLLSTTR 9
            ES LLSTTR
Sbjct: 1195 ESCLLSTTR 1203
>NP_001275703
          Length = 1264

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ESGLLSTTR 9
            ES LLSTTR
Sbjct: 1014 ESCLLSTTR 1022
>XP_005253450
          Length = 1486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ESGLLSTTR 9
            ES LLSTTR
Sbjct: 1236 ESCLLSTTR 1244
>XP_006719151
          Length = 1486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ESGLLSTTR 9
            ES LLSTTR
Sbjct: 1236 ESCLLSTTR 1244
>XP_005252905
          Length = 1854

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLLSTT
Sbjct: 742 SGLLSTT 748
>XP_005252904
          Length = 1855

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLLSTT
Sbjct: 742 SGLLSTT 748
>NP_036326
          Length = 1849

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLLSTT
Sbjct: 736 SGLLSTT 742
>NP_001188267
          Length = 917

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 411 SGLSSTTR 418
>NP_001188269
          Length = 848

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 342 SGLSSTTR 349
>NP_002958
          Length = 915

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 411 SGLSSTTR 418
>NP_001188268
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 411 SGLSSTTR 418
>NP_078858
          Length = 4981

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SGLLSTTR 9
            +G+LSTTR
Sbjct: 3563 AGVLSTTR 3570
>NP_001278232
          Length = 4983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SGLLSTTR 9
            +G+LSTTR
Sbjct: 3565 AGVLSTTR 3572
>NP_001278214
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SGLLSTTR 9
            +G+LSTTR
Sbjct: 3565 AGVLSTTR 3572
>NP_060376
          Length = 392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ESGL+ST +
Sbjct: 364 ESGLISTKK 372
>NP_057664
          Length = 1184

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ESGLLSTTR 9
          E GLLST R
Sbjct: 82 EEGLLSTGR 90
>NP_055464
          Length = 953

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 412 SGLSSTTR 419
>XP_006722902
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SGLLSTTR 9
           SGL STTR
Sbjct: 411 SGLSSTTR 418
>XP_006715192
          Length = 368

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ESGL+ST +
Sbjct: 340 ESGLISTKK 348
>XP_005249261
          Length = 393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ESGL+ST +
Sbjct: 365 ESGLISTKK 373
>NP_061885
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 698 QNGLLSTCR 706
>NP_001243716
          Length = 1098

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 617 QNGLLSTCR 625
>NP_001243399
          Length = 1282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 801 QNGLLSTCR 809
>NP_001137293
          Length = 1174

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 756 QNGLLSTCR 764
>XP_006719159
          Length = 1276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 795 QNGLLSTCR 803
>XP_006719157
          Length = 1128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 647 QNGLLSTCR 655
>XP_006719156
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 670 QNGLLSTCR 678
>XP_006719155
          Length = 1173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 755 QNGLLSTCR 763
>XP_005253457
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 698 QNGLLSTCR 706
>XP_006719154
          Length = 1197

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 716 QNGLLSTCR 724
>XP_005253456
          Length = 1206

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 725 QNGLLSTCR 733
>XP_005253455
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 737 QNGLLSTCR 745
>XP_006719153
          Length = 1224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 743 QNGLLSTCR 751
>XP_006719152
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ESGLLSTTR 9
           ++GLLST R
Sbjct: 755 QNGLLSTCR 763
>NP_001136025
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESGLLSTTR 9
           ESG +ST R
Sbjct: 611 ESGAISTIR 619
>NP_001136024
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ESGLLSTTR 9
           ESG +ST R
Sbjct: 611 ESGAISTIR 619
>NP_060109
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SGLLSTT 8
            SGLL+TT
Sbjct: 1218 SGLLTTT 1224
>NP_004217
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  SGLLSTT 8
          SGLL+TT
Sbjct: 12 SGLLTTT 18
>NP_005236
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SGLLSTT 8
            SG+LSTT
Sbjct: 2029 SGVLSTT 2035
>XP_005270370
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLL+TT
Sbjct: 193 SGLLNTT 199
>XP_006717680
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLL+TT
Sbjct: 193 SGLLNTT 199
>XP_006714202
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SGLLSTT 8
            SG+LSTT
Sbjct: 2029 SGVLSTT 2035
>XP_005262892
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SGLLSTT 8
            SG+LSTT
Sbjct: 2029 SGVLSTT 2035
>XP_005262891
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SGLLSTT 8
            SG+LSTT
Sbjct: 2029 SGVLSTT 2035
>NP_001035194
          Length = 4493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ESGLLSTT 8
            E+G LSTT
Sbjct: 2472 EAGTLSTT 2479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ESGLLSTT 8
            E+G LSTT
Sbjct: 2826 EAGTLSTT 2833
>NP_056471
          Length = 1882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ESGLLSTT 8
            E GLL+TT
Sbjct: 1010 ERGLLTTT 1017
>NP_694579
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SGLLSTT 8
           SGLL+TT
Sbjct: 193 SGLLNTT 199
>NP_056485
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ESGLLSTT 8
           +SGLLS T
Sbjct: 237 DSGLLSCT 244
>NP_056164
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GLLSTT 8
           GLLSTT
Sbjct: 641 GLLSTT 646
>NP_001073869
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1119 DTGLLATT 1126
>NP_071896
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GLLSTTR 9
           G+L+TTR
Sbjct: 644 GILATTR 650
>XP_006722933
          Length = 1240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1002 DTGLLATT 1009
>XP_006722932
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1068 DTGLLATT 1075
>XP_006722931
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1133 DTGLLATT 1140
>XP_006722930
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1134 DTGLLATT 1141
>XP_005259697
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1134 DTGLLATT 1141
>XP_006722929
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ESGLLSTT 8
            ++GLL+TT
Sbjct: 1134 DTGLLATT 1141
>XP_005249030
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GLLSTT 8
           GLLSTT
Sbjct: 641 GLLSTT 646
>XP_005249029
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GLLSTT 8
           GLLSTT
Sbjct: 641 GLLSTT 646
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.117    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,335
Number of extensions: 833
Number of successful extensions: 61
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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