Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_570711                                                              21     229
NP_570712                                                              21     229
NP_570714                                                              21     229
NP_570713                                                              21     229
NP_570716                                                              21     229
NP_000235                                                              21     229
NP_570715                                                              21     229
XP_006718620                                                           21     229
XP_005274059                                                           21     229
XP_005274060                                                           21     229
XP_005274058                                                           21     229
XP_005276387                                                           18    1482
XP_005272420                                                           18    1482
XP_005276080                                                           18    1482
XP_005250117                                                           17    3301
NP_003583                                                              17    3301
NP_009049                                                              16    5631
NP_001157576                                                           16    5631
NP_001157577                                                           16    5631
NP_061868                                                              16    5631
NP_203751                                                              16    5631
XP_006725221                                                           16    5631
XP_006724481                                                           16    5631
XP_005261980                                                           16    5631
XP_006714558                                                           16    5631
XP_006714456                                                           16    5631
XP_005263376                                                           16    5631
NP_002302                                                              16    7355
NP_057057                                                              16    7355
NP_874362                                                              16    7355
XP_006721959                                                           16    7355
XP_006718643                                                           16    7355
NP_079042                                                              15    9605
NP_004553                                                              15    9605
NP_054642                                                              15    9605
NP_003986                                                              15    9605
NP_000897                                                              15    9605
NP_001269616                                                           15    9605
NP_056492                                                              15    9605
NP_001153069                                                           15    9605
NP_060598                                                              15    9605
NP_001073949                                                           15    9605
NP_001269611                                                           15    9605
XP_005251536                                                           15    9605
XP_006716841                                                           15    9605
XP_005251535                                                           15    9605
XP_006715062                                                           15    9605
XP_005264624                                                           15    9605
XP_005245275                                                           15    9605
XP_006711406                                                           15    9605
XP_006711405                                                           15    9605
NP_003384                                                              15    9605
>NP_570711
          Length = 610

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 205 DRRGQTVNA 213
>NP_570712
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>NP_570714
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>NP_570713
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>NP_570716
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>NP_000235
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>NP_570715
          Length = 615

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 210 DRRGQTVNA 218
>XP_006718620
          Length = 610

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 205 DRRGQTVNA 213
>XP_005274059
          Length = 610

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 205 DRRGQTVNA 213
>XP_005274060
          Length = 610

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 205 DRRGQTVNA 213
>XP_005274058
          Length = 610

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ERRGQTVNA 9
           +RRGQTVNA
Sbjct: 205 DRRGQTVNA 213
>XP_005276387
          Length = 262

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ERRGQTVNA 9
          ERR QT NA
Sbjct: 25 ERRAQTANA 33
>XP_005272420
          Length = 262

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ERRGQTVNA 9
          ERR QT NA
Sbjct: 25 ERRAQTANA 33
>XP_005276080
          Length = 262

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ERRGQTVNA 9
          ERR QT NA
Sbjct: 25 ERRAQTANA 33
>XP_005250117
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERRGQTVN 8
           ER G+T+N
Sbjct: 190 ERNGETIN 197
>NP_003583
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERRGQTVN 8
           ER G+T+N
Sbjct: 190 ERNGETIN 197
>NP_009049
          Length = 3097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RRGQTV 7
            RRGQTV
Sbjct: 1678 RRGQTV 1683
>NP_001157576
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           RRG  VNA
Sbjct: 218 RRGDVVNA 225
>NP_001157577
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           RRG  VNA
Sbjct: 198 RRGDVVNA 205
>NP_061868
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           RRG  VNA
Sbjct: 218 RRGDVVNA 225
>NP_203751
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRGQTVNA 9
           RRG+T+N+
Sbjct: 151 RRGRTLNS 158
>XP_006725221
          Length = 165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RRGQTV 7
          RRGQTV
Sbjct: 9  RRGQTV 14
>XP_006724481
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           RRG  VNA
Sbjct: 218 RRGDVVNA 225
>XP_005261980
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           RRG  VNA
Sbjct: 198 RRGDVVNA 205
>XP_006714558
          Length = 2612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RRGQTV 7
            RRGQTV
Sbjct: 1193 RRGQTV 1198
>XP_006714456
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRGQTVNA 9
           RRG+T+N+
Sbjct: 151 RRGRTLNS 158
>XP_005263376
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRGQTVNA 9
           RRG+T+N+
Sbjct: 151 RRGRTLNS 158
>NP_002302
          Length = 949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ERRGQTVNA 9
           E+RG+TV A
Sbjct: 938 EQRGRTVPA 946
>NP_057057
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ERRGQTVNA 9
          E+RG T+N+
Sbjct: 30 EKRGWTLNS 38
>NP_874362
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRGQTVNA 9
           R G TVNA
Sbjct: 246 RAGSTVNA 253
>XP_006721959
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ERRGQTVNA 9
           E+RG+TV A
Sbjct: 947 EQRGRTVPA 955
>XP_006718643
          Length = 133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ERRGQTVNA 9
          E+RG T+N+
Sbjct: 30 EKRGWTLNS 38
>NP_079042
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RRGQTVN 8
           RRG T+N
Sbjct: 263 RRGNTLN 269
>NP_004553
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RRGQTVNA 9
          R+GQ +NA
Sbjct: 75 RKGQEMNA 82
>NP_054642
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RRGQTVNA 9
          R+GQ +NA
Sbjct: 75 RKGQEMNA 82
>NP_003986
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 847 KRGETVQA 854
>NP_000897
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 862 KRGETVQA 869
>NP_001269616
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ERRGQTVNA 9
           E  GQ +NA
Sbjct: 119 ENEGQRINA 127
>NP_056492
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ERRGQTVNA 9
           E  GQ +NA
Sbjct: 215 ENEGQRINA 223
>NP_001153069
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ERRGQTVNA 9
           E  GQ +NA
Sbjct: 215 ENEGQRINA 223
>NP_060598
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RGQTVN 8
           RGQT+N
Sbjct: 279 RGQTLN 284
>NP_001073949
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERRGQTVNA 9
           +RR QT+N+
Sbjct: 480 QRRPQTLNS 488
>NP_001269611
          Length = 227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ERRGQTVNA 9
           E  GQ +NA
Sbjct: 119 ENEGQRINA 127
>XP_005251536
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 521 KRGETVQA 528
>XP_006716841
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 826 KRGETVQA 833
>XP_005251535
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 850 KRGETVQA 857
>XP_006715062
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERRGQTVNA 9
           +RR QT+N+
Sbjct: 448 QRRPQTLNS 456
>XP_005264624
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RRGQTVN 8
           RRG T+N
Sbjct: 107 RRGNTLN 113
>XP_005245275
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 836 KRGETVQA 843
>XP_006711406
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 837 KRGETVQA 844
>XP_006711405
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RRGQTVNA 9
           +RG+TV A
Sbjct: 863 KRGETVQA 870
>NP_003384
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERRGQTVNA 9
           ERR +TV++
Sbjct: 300 ERRAETVSS 308
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.122    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 499,741
Number of extensions: 533
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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