Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              18    1135
NP_004829                                                              16    5631
NP_001139193                                                           16    5631
NP_001139196                                                           16    5631
NP_001139194                                                           16    5631
NP_055616                                                              16    5631
NP_005018                                                              16    5631
NP_001032406                                                           16    5631
XP_006723007                                                           16    5631
XP_006723006                                                           16    5631
XP_006718209                                                           16    5631
XP_006718208                                                           16    5631
XP_006718207                                                           16    5631
XP_005252850                                                           16    5631
XP_006711879                                                           16    5631
XP_005273329                                                           16    5631
NP_055947                                                              16    7355
NP_079406                                                              16    7355
XP_005249729                                                           16    7355
NP_001073953                                                           15    9605
NP_001273572                                                           15    9605
NP_057026                                                              15    9605
NP_001796                                                              15    9605
NP_002758                                                              15    9605
NP_001230865                                                           15    9605
NP_001273897                                                           15    9605
NP_005345                                                              15    9605
NP_001230871                                                           15    9605
NP_001230869                                                           15    9605
NP_001230870                                                           15    9605
XP_005256786                                                           15    9605
XP_005256784                                                           15    9605
XP_005256783                                                           15    9605
XP_005256782                                                           15    9605
XP_005256781                                                           15    9605
XP_006716633                                                           15    9605
XP_006716632                                                           15    9605
XP_005250984                                                           15    9605
XP_006716631                                                           15    9605
XP_005250983                                                           15    9605
XP_006711061                                                           15    9605
XP_006711060                                                           15    9605
XP_005244868                                                           15    9605
>NP_115803
          Length = 1156

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  ERLRTRIAV 9
          ERLR RIAV
Sbjct: 38 ERLRARIAV 46
>NP_004829
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 225 ERLRQRVA 232
>NP_001139193
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 225 ERLRQRVA 232
>NP_001139196
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 189 ERLRQRVA 196
>NP_001139194
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 225 ERLRQRVA 232
>NP_055616
          Length = 2137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ERLRTRIA 8
           ERL+TR++
Sbjct: 456 ERLKTRVS 463
>NP_005018
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ERLRTRIA 8
           ERL++RIA
Sbjct: 526 ERLKSRIA 533
>NP_001032406
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  +AV
Sbjct: 328 ERLRAEVAV 336
>XP_006723007
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 225 ERLRQRVA 232
>XP_006723006
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           ERLR R+A
Sbjct: 225 ERLRQRVA 232
>XP_006718209
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  +AV
Sbjct: 288 ERLRAEVAV 296
>XP_006718208
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  +AV
Sbjct: 288 ERLRAEVAV 296
>XP_006718207
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  +AV
Sbjct: 328 ERLRAEVAV 336
>XP_005252850
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  +AV
Sbjct: 388 ERLRAEVAV 396
>XP_006711879
          Length = 1364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ERLRTRIA 8
           ERL+TR++
Sbjct: 456 ERLKTRVS 463
>XP_005273329
          Length = 1934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ERLRTRIA 8
           ERL+TR++
Sbjct: 253 ERLKTRVS 260
>NP_055947
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLRTRIA 8
           R+RTR+A
Sbjct: 859 RMRTRVA 865
>NP_079406
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERLRTR 6
           ERLRTR
Sbjct: 773 ERLRTR 778
>XP_005249729
          Length = 968

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLRTRIA 8
           R+RTR+A
Sbjct: 870 RMRTRVA 876
>NP_001073953
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ERLRTRI 7
           ERLR+R+
Sbjct: 493 ERLRSRV 499
>NP_001273572
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 221 ENLKTRVA 228
>NP_057026
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 221 ENLKTRVA 228
>NP_001796
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ERLRTRI 7
           ERLR+R+
Sbjct: 244 ERLRSRV 250
>NP_002758
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 201 ERLRLGIAV 209
>NP_001230865
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 161 ERLRLGIAV 169
>NP_001273897
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           +RLR RIA
Sbjct: 231 KRLRNRIA 238
>NP_005345
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           +RLR RIA
Sbjct: 274 KRLRNRIA 281
>NP_001230871
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 115 ERLRLGIAV 123
>NP_001230869
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 201 ERLRLGIAV 209
>NP_001230870
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 115 ERLRLGIAV 123
>XP_005256786
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 115 ERLRLGIAV 123
>XP_005256784
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 115 ERLRLGIAV 123
>XP_005256783
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 201 ERLRLGIAV 209
>XP_005256782
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 201 ERLRLGIAV 209
>XP_005256781
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ERLRTRIAV 9
           ERLR  IAV
Sbjct: 201 ERLRLGIAV 209
>XP_006716633
          Length = 227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ERLRTRIA 8
          E L+TR+A
Sbjct: 31 ENLKTRVA 38
>XP_006716632
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 100 ENLKTRVA 107
>XP_005250984
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 100 ENLKTRVA 107
>XP_006716631
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 108 ENLKTRVA 115
>XP_005250983
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ERLRTRIA 8
           E L+TR+A
Sbjct: 221 ENLKTRVA 228
>XP_006711061
          Length = 1553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ERLRTRI 7
           ERLR+R+
Sbjct: 407 ERLRSRV 413
>XP_006711060
          Length = 1595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ERLRTRI 7
           ERLR+R+
Sbjct: 449 ERLRSRV 455
>XP_005244868
          Length = 1639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ERLRTRI 7
           ERLR+R+
Sbjct: 493 ERLRSRV 499
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.143    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,615
Number of extensions: 563
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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