Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              19     665
NP_001035957                                                           19     665
XP_006721991                                                           19     665
XP_006721990                                                           19     665
XP_006721989                                                           19     665
XP_005258041                                                           19     665
XP_006721988                                                           19     665
XP_006721987                                                           19     665
XP_006721986                                                           19     665
XP_005258040                                                           19     665
XP_006721985                                                           19     665
NP_001258625                                                           16    7355
NP_001258627                                                           16    7355
NP_004290                                                              16    7355
NP_001258628                                                           16    7355
NP_001253969                                                           16    7355
NP_005680                                                              16    7355
NP_004964                                                              16    7355
NP_001258626                                                           16    7355
NP_005654                                                              16    7355
NP_291025                                                              16    7355
XP_005274450                                                           16    7355
XP_005249146                                                           16    7355
XP_006713980                                                           16    7355
XP_006713979                                                           16    7355
NP_056099                                                              15    9605
NP_009143                                                              15    9605
XP_005245470                                                           15    9605
XP_006710565                                                           15    9605
XP_006710564                                                           15    9605
XP_005270743                                                           15    9605

>NP_000258
          Length = 2818

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1415 ERGLKLMS 1422



>NP_001035957
          Length = 2839

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1436 ERGLKLMS 1443



>XP_006721991
          Length = 1632

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1446 ERGLKLMS 1453



>XP_006721990
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1446 ERGLKLMS 1453



>XP_006721989
          Length = 2823

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1446 ERGLKLMS 1453



>XP_005258041
          Length = 2836

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1415 ERGLKLMS 1422



>XP_006721988
          Length = 2846

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1425 ERGLKLMS 1432



>XP_006721987
          Length = 2849

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1446 ERGLKLMS 1453



>XP_006721986
          Length = 2854

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1433 ERGLKLMS 1440



>XP_005258040
          Length = 2857

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1436 ERGLKLMS 1443



>XP_006721985
          Length = 2867

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    ERGLKLMS 8
            ERGLKLMS
Sbjct: 1446 ERGLKLMS 1453



>NP_001258625
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 604 ERGLKL 609



>NP_001258627
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 578 ERGLKL 583



>NP_004290
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 605 ERGLKL 610



>NP_001258628
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 565 ERGLKL 570



>NP_001253969
          Length = 1074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RGLKLM 7
            RGLKLM
Sbjct: 1004 RGLKLM 1009



>NP_005680
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 722 ERGLKL 727



>NP_004964
          Length = 1246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RGLKLM 7
            RGLKLM
Sbjct: 1176 RGLKLM 1181



>NP_001258626
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 564 ERGLKL 569



>NP_005654
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERGLKLMSM 9
           ERG+KL+ +
Sbjct: 262 ERGVKLLDI 270



>NP_291025
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 224 ERGLKL 229



>XP_005274450
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ERGLKL 6
           ERGLKL
Sbjct: 224 ERGLKL 229



>XP_005249146
          Length = 1074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RGLKLM 7
            RGLKLM
Sbjct: 1004 RGLKLM 1009



>XP_006713980
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERGLKLMSM 9
           ERG+KL+ +
Sbjct: 181 ERGVKLLDI 189



>XP_006713979
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ERGLKLMSM 9
           ERG+KL+ +
Sbjct: 287 ERGVKLLDI 295



>NP_056099
          Length = 3375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RGLKLMS 8
            RGL LMS
Sbjct: 1794 RGLSLMS 1800



>NP_009143
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ERGLKLMSM 9
           E GLK+ +M
Sbjct: 145 EEGLKIQAM 153



>XP_005245470
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ERGLKLMSM 9
           E GLK+ +M
Sbjct: 96  EEGLKIQAM 104



>XP_006710565
          Length = 3140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RGLKLMS 8
            RGL LMS
Sbjct: 1559 RGLSLMS 1565



>XP_006710564
          Length = 3432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RGLKLMS 8
            RGL LMS
Sbjct: 1851 RGLSLMS 1857



>XP_005270743
          Length = 3453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RGLKLMS 8
            RGL LMS
Sbjct: 1872 RGLSLMS 1878



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.135    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 395,948
Number of extensions: 316
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)