Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     390
NP_004561                                                              20     390
XP_005253450                                                           20     390
XP_006719151                                                           20     390
NP_853514                                                              17    2528
NP_001245366                                                           17    2528
NP_689508                                                              17    2528
NP_001245367                                                           17    2528
NP_000825                                                              17    4312
NP_945185                                                              17    4312
NP_001136175                                                           17    4312
NP_001136176                                                           17    4312
NP_477352                                                              17    4312
NP_002641                                                              17    4312
XP_005261692                                                           17    4312
XP_005261691                                                           17    4312
NP_001265092                                                           16    5631
NP_001265091                                                           16    5631
NP_005725                                                              16    5631
NP_001041665                                                           16    5631
XP_006718183                                                           16    5631
XP_005252786                                                           16    5631
NP_001126                                                              16    7355
NP_037359                                                              16    7355
NP_001188386                                                           16    7355
NP_938207                                                              16    7355
NP_112562                                                              16    7355
NP_002431                                                              16    7355
NP_689547                                                              16    7355
NP_006648                                                              16    7355
NP_115744                                                              16    7355
NP_996848                                                              16    7355
XP_006724025                                                           16    7355
XP_006724024                                                           16    7355
XP_006724023                                                           16    7355
XP_006722041                                                           16    7355
XP_005257576                                                           16    7355
XP_006722040                                                           16    7355
XP_006722039                                                           16    7355
XP_005257575                                                           16    7355
XP_006720482                                                           16    7355
XP_006720449                                                           16    7355
XP_005254915                                                           16    7355
XP_005263566                                                           16    7355
XP_005263564                                                           16    7355
XP_005263565                                                           16    7355
XP_005263562                                                           16    7355
XP_005263563                                                           16    7355
NP_001121113                                                           15    9605
NP_001017402                                                           15    9605
NP_000219                                                              15    9605
NP_000382                                                              15    9605
NP_751895                                                              15    9605
NP_004691                                                              15    9605
NP_036552                                                              15    9605
NP_689472                                                              15    9605
NP_077741                                                              15    9605
NP_001932                                                              15    9605
XP_003960647                                                           15    9605
XP_003403507                                                           15    9605
XP_006720120                                                           15    9605
XP_006720119                                                           15    9605
XP_005273181                                                           15    9605
NP_689659                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  EQIVDEISG 9
          +QIVDEISG
Sbjct: 41 DQIVDEISG 49
>NP_004561
          Length = 1445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  EQIVDEISG 9
          +QIVDEISG
Sbjct: 41 DQIVDEISG 49
>XP_005253450
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  EQIVDEISG 9
          +QIVDEISG
Sbjct: 41 DQIVDEISG 49
>XP_006719151
          Length = 1486

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  EQIVDEISG 9
          +QIVDEISG
Sbjct: 41 DQIVDEISG 49
>NP_853514
          Length = 1732

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QIVDEISG 9
           Q++DEI+G
Sbjct: 278 QVIDEIAG 285
>NP_001245366
          Length = 723

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI DEI G
Sbjct: 470 EQIEDEIKG 478
>NP_689508
          Length = 723

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI DEI G
Sbjct: 470 EQIEDEIKG 478
>NP_001245367
          Length = 756

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI DEI G
Sbjct: 503 EQIEDEIKG 511
>NP_000825
          Length = 1484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EQIVDEISG 9
           E+ VD++SG
Sbjct: 657 EEYVDQVSG 665
>NP_945185
          Length = 734

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EQIVDEISG 9
           + +VDE+SG
Sbjct: 253 QSMVDEVSG 261
>NP_001136175
          Length = 704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EQIVDEISG 9
           + +VDE+SG
Sbjct: 223 QSMVDEVSG 231
>NP_001136176
          Length = 704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EQIVDEISG 9
           + +VDE+SG
Sbjct: 223 QSMVDEVSG 231
>NP_477352
          Length = 2102

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    EQIVDEISG 9
            +Q+V+EI+G
Sbjct: 1713 DQLVEEITG 1721
>NP_002641
          Length = 854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EQIVDEISG 9
           +Q+V+EI+G
Sbjct: 465 DQLVEEITG 473
>XP_005261692
          Length = 1854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    EQIVDEISG 9
            +Q+V+EI+G
Sbjct: 1465 DQLVEEITG 1473
>XP_005261691
          Length = 2099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    EQIVDEISG 9
            +Q+V+EI+G
Sbjct: 1710 DQLVEEITG 1718
>NP_001265092
          Length = 1194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>NP_001265091
          Length = 1194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>NP_005725
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>NP_001041665
          Length = 1194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>XP_006718183
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>XP_005252786
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           QIVDE+S
Sbjct: 142 QIVDELS 148
>NP_001126
          Length = 2431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VDEISG 9
            VDEISG
Sbjct: 1426 VDEISG 1431
>NP_037359
          Length = 2530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VDEISG 9
            VDEISG
Sbjct: 1426 VDEISG 1431
>NP_001188386
          Length = 1497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 758 EQILDEV 764
>NP_938207
          Length = 1491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 752 EQILDEV 758
>NP_112562
          Length = 1451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 752 EQILDEV 758
>NP_002431
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QIVDEISG 9
           +IVD+I+G
Sbjct: 507 EIVDDIAG 514
>NP_689547
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI +EI G
Sbjct: 549 EQIEEEIKG 557
>NP_006648
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          ++++D ISG
Sbjct: 17 QEVIDAISG 25
>NP_115744
          Length = 190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>NP_996848
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          ++++D ISG
Sbjct: 17 QEVIDAISG 25
>XP_006724025
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          ++++D ISG
Sbjct: 17 QEVIDAISG 25
>XP_006724024
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          ++++D ISG
Sbjct: 17 QEVIDAISG 25
>XP_006724023
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          ++++D ISG
Sbjct: 17 QEVIDAISG 25
>XP_006722041
          Length = 1445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 755 EQILDEV 761
>XP_005257576
          Length = 1454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 755 EQILDEV 761
>XP_006722040
          Length = 1466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 755 EQILDEV 761
>XP_006722039
          Length = 1491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 752 EQILDEV 758
>XP_005257575
          Length = 1494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQI+DE+
Sbjct: 755 EQILDEV 761
>XP_006720482
          Length = 2568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VDEISG 9
            VDEISG
Sbjct: 1426 VDEISG 1431
>XP_006720449
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI +EI G
Sbjct: 549 EQIEEEIKG 557
>XP_005254915
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EQIVDEISG 9
           EQI +EI G
Sbjct: 488 EQIEEEIKG 496
>XP_005263566
          Length = 145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>XP_005263564
          Length = 190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>XP_005263565
          Length = 190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>XP_005263562
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>XP_005263563
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVDEISG 9
          +VDE+SG
Sbjct: 70 LVDELSG 76
>NP_001121113
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EQIVDEISG 9
            EQI D I+G
Sbjct: 1155 EQIRDHING 1163
>NP_001017402
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EQIVDEISG 9
            EQI D I+G
Sbjct: 1155 EQIRDHING 1163
>NP_000219
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EQIVDEISG 9
            EQI D I+G
Sbjct: 1155 EQIRDHING 1163
>NP_000382
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QIVDEISG 9
           +IVD ISG
Sbjct: 402 EIVDYISG 409
>NP_751895
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           ++VDEIS
Sbjct: 554 EVVDEIS 560
>NP_004691
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QIVDEIS 8
           ++VDEIS
Sbjct: 608 EVVDEIS 614
>NP_036552
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EQIVDEIS 8
           E+I+D+IS
Sbjct: 239 EEILDQIS 246
>NP_689472
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EQIVDEIS 8
           EQ+V+E++
Sbjct: 744 EQVVEEVT 751
>NP_077741
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDEISG 9
           +DEISG
Sbjct: 520 IDEISG 525
>NP_001932
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDEISG 9
           +DEISG
Sbjct: 520 IDEISG 525
>XP_003960647
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          +Q+V E+SG
Sbjct: 72 QQLVRELSG 80
>XP_003403507
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EQIVDEISG 9
          +Q+V E+SG
Sbjct: 72 QQLVRELSG 80
>XP_006720120
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQ++DEI
Sbjct: 885 EQLLDEI 891
>XP_006720119
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQ++DEI
Sbjct: 924 EQLLDEI 930
>XP_005273181
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EQIVDEISG 9
            EQI D I+G
Sbjct: 1155 EQIRDHING 1163
>NP_689659
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EQIVDEI 7
           EQ++DEI
Sbjct: 924 EQLLDEI 930
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.133    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,935
Number of extensions: 1066
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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