Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              20     390
XP_006713721                                                           20     390
XP_005248822                                                           18    1935
NP_078852                                                              18    1935
NP_001124396                                                           16    5631
NP_001010866                                                           16    5631
NP_001127890                                                           16    5631
NP_001273282                                                           16    5631
NP_001273281                                                           16    5631
NP_060662                                                              16    5631
NP_064575                                                              16    5631
XP_006710841                                                           16    5631
XP_006710481                                                           16    5631
XP_006710480                                                           16    5631
NP_001275544                                                           16    7355
NP_570925                                                              16    7355
NP_570924                                                              16    7355
NP_570923                                                              16    7355
NP_068749                                                              16    7355
NP_002841                                                              16    7355
NP_001275545                                                           16    7355
XP_006722884                                                           16    7355
XP_005259667                                                           16    7355
XP_005259666                                                           16    7355
XP_006722883                                                           16    7355
XP_006722882                                                           16    7355
XP_006722881                                                           16    7355
XP_005259664                                                           16    7355
XP_005259663                                                           16    7355
XP_006722880                                                           16    7355
XP_006722879                                                           16    7355
XP_006722878                                                           16    7355
XP_006722877                                                           16    7355
XP_006722876                                                           16    7355
XP_006722875                                                           16    7355
XP_005259658                                                           16    7355
XP_005259657                                                           16    7355
XP_006722874                                                           16    7355
XP_006722873                                                           16    7355
XP_006722872                                                           16    7355
XP_006722871                                                           16    7355
XP_006720713                                                           16    7355
XP_006720712                                                           16    7355
XP_006720711                                                           16    7355
XP_005255029                                                           16    7355
XP_005255030                                                           16    7355
XP_006720710                                                           16    7355
XP_005255027                                                           16    7355
XP_005255028                                                           16    7355
XP_005255026                                                           16    7355
XP_005250581                                                           16    7355
NP_054900                                                              16    7355
NP_001124481                                                           15    9605
NP_001124480                                                           15    9605
NP_002826                                                              15    9605
XP_006716137                                                           15    9605
XP_005250575                                                           15    9605
XP_006716136                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EQAALEYFM 9
            EQ ALEYFM
Sbjct: 1032 EQEALEYFM 1040
>XP_006713721
          Length = 1068

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EQAALEYFM 9
            EQ ALEYFM
Sbjct: 1032 EQEALEYFM 1040
>XP_005248822
          Length = 452

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EQAALEYFM 9
           +Q+ALEYF+
Sbjct: 277 KQSALEYFV 285
>NP_078852
          Length = 451

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   EQAALEYFM 9
           +Q+ALEYF+
Sbjct: 276 KQSALEYFV 284
>NP_001124396
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QAALEYFM 9
           QAA+EY++
Sbjct: 168 QAAVEYYI 175
>NP_001010866
          Length = 392

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QAALEYFM 9
           QAA+EY++
Sbjct: 168 QAAVEYYI 175
>NP_001127890
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EQAALEYFM 9
          EQA  EYF+
Sbjct: 53 EQALREYFV 61
>NP_001273282
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           E+AAL YF
Sbjct: 297 ERAALPYF 304
>NP_001273281
          Length = 386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           E+AAL YF
Sbjct: 338 ERAALPYF 345
>NP_060662
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EQAALEYFM 9
           EQA  EYF+
Sbjct: 234 EQALREYFV 242
>NP_064575
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           E+AAL YF
Sbjct: 358 ERAALPYF 365
>XP_006710841
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           E+AAL YF
Sbjct: 297 ERAALPYF 304
>XP_006710481
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QAALEYFM 9
           QAA+EY++
Sbjct: 168 QAAVEYYI 175
>XP_006710480
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QAALEYFM 9
           QAA+EY++
Sbjct: 168 QAAVEYYI 175
>NP_001275544
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>NP_570925
          Length = 1505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1491 QAALEY 1496
>NP_570924
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1896 QAALEY 1901
>NP_570923
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1487 QAALEY 1492
>NP_068749
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           +QAALE F
Sbjct: 563 QQAALEVF 570
>NP_002841
          Length = 1948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1934 QAALEY 1939
>NP_001275545
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006722884
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1476 QAALEY 1481
>XP_005259667
          Length = 1497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1483 QAALEY 1488
>XP_005259666
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1487 QAALEY 1492
>XP_006722883
          Length = 1510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1496 QAALEY 1501
>XP_006722882
          Length = 1522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1508 QAALEY 1513
>XP_006722881
          Length = 1526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1512 QAALEY 1517
>XP_005259664
          Length = 1906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1892 QAALEY 1897
>XP_005259663
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1896 QAALEY 1901
>XP_006722880
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1901 QAALEY 1906
>XP_006722879
          Length = 1917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1903 QAALEY 1908
>XP_006722878
          Length = 1924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1910 QAALEY 1915
>XP_006722877
          Length = 1928

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1914 QAALEY 1919
>XP_006722876
          Length = 1933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1919 QAALEY 1924
>XP_006722875
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_005259658
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_005259657
          Length = 1935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1921 QAALEY 1926
>XP_006722874
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1926 QAALEY 1931
>XP_006722873
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006722872
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006722871
          Length = 1944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    QAALEY 7
            QAALEY
Sbjct: 1930 QAALEY 1935
>XP_006720713
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 225 QAALEY 230
>XP_006720712
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006720711
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255029
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255030
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_006720710
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255027
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255028
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005255026
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   QAALEY 7
           QAALEY
Sbjct: 210 QAALEY 215
>XP_005250581
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           +QAALE F
Sbjct: 222 QQAALEVF 229
>NP_054900
          Length = 172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EQAALEYF 8
           EQ+A+ YF
Sbjct: 109 EQSAIPYF 116
>NP_001124481
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EQAALEYFM 9
          EQA  +YF+
Sbjct: 37 EQARTDYFI 45
>NP_001124480
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EQAALEYFM 9
          EQA  +YF+
Sbjct: 48 EQARTDYFI 56
>NP_002826
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EQAALEYFM 9
           EQA  +YF+
Sbjct: 167 EQARTDYFI 175
>XP_006716137
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EQAALEYFM 9
          EQA  +YF+
Sbjct: 52 EQARTDYFI 60
>XP_005250575
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EQAALEYFM 9
          EQA  +YF+
Sbjct: 52 EQARTDYFI 60
>XP_006716136
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EQAALEYFM 9
           EQA  +YF+
Sbjct: 135 EQARTDYFI 143
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.130    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 393,599
Number of extensions: 502
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package