Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     509
NP_663780                                                              18    1482
NP_056101                                                              18    1482
NP_001120                                                              17    3301
NP_001139784                                                           17    4312
NP_705832                                                              17    4312
NP_055160                                                              17    4312
NP_001020774                                                           17    4312
NP_001001971                                                           17    4312
NP_060899                                                              17    4312
NP_937858                                                              17    4312
NP_000440                                                              17    4312
XP_006725524                                                           17    4312
XP_006725523                                                           17    4312
XP_005276828                                                           17    4312
XP_006726279                                                           17    4312
XP_005256921                                                           17    4312
XP_005256920                                                           17    4312
XP_005269676                                                           17    4312
XP_005269675                                                           17    4312
XP_006714722                                                           17    4312
XP_006714721                                                           17    4312
XP_005245463                                                           17    4312
XP_005245462                                                           17    4312
NP_004371                                                              16    5631
NP_001073315                                                           16    5631
NP_001004334                                                           16    5631
XP_005255182                                                           16    5631
XP_006720911                                                           16    5631
XP_005255181                                                           16    5631
NP_001968                                                              16    5631
NP_817092                                                              16    7355
NP_775885                                                              16    7355
NP_001004060                                                           16    7355
NP_001004067                                                           16    7355
NP_071941                                                              16    7355
XP_003846519                                                           16    7355
XP_006725258                                                           16    7355
XP_006721059                                                           16    7355
XP_005255375                                                           16    7355
XP_006719760                                                           16    7355
XP_006719759                                                           16    7355
XP_006719758                                                           16    7355
XP_005254048                                                           16    7355
XP_006719757                                                           16    7355
XP_006710314                                                           16    7355
NP_997194                                                              16    7355
NP_055102                                                              16    7355
NP_008880                                                              15    9605
NP_001258963                                                           15    9605
NP_001120868                                                           15    9605
NP_001130009                                                           15    9605
NP_055721                                                              15    9605
NP_006011                                                              15    9605
NP_005413                                                              15    9605
NP_115725                                                              15    9605
XP_006722914                                                           15    9605
XP_006721765                                                           15    9605
XP_006721764                                                           15    9605
XP_005271710                                                           15    9605
XP_005245315                                                           15    9605
XP_006711447                                                           15    9605
XP_005245314                                                           15    9605
XP_006710450                                                           15    9605
NP_002637                                                              15    9605
NP_149124                                                              15    9605
>NP_055365
          Length = 1032

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EPREQ VEA
Sbjct: 646 EPREQRVEA 654
>NP_663780
          Length = 1565

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EPREQMVE 8
           EPR+Q+VE
Sbjct: 944 EPRQQLVE 951
>NP_056101
          Length = 1253

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EPREQMVE 8
           EPR+Q+VE
Sbjct: 944 EPRQQLVE 951
>NP_001120
          Length = 1158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  EPREQMVEA 9
          EPRE  VEA
Sbjct: 48 EPREDDVEA 56
>NP_001139784
          Length = 986

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPREQMV 7
           EP EQMV
Sbjct: 325 EPNEQMV 331
>NP_705832
          Length = 938

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPREQMV 7
           EP EQMV
Sbjct: 325 EPNEQMV 331
>NP_055160
          Length = 2279

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    PREQMVE 8
            PREQ++E
Sbjct: 2245 PREQVIE 2251
>NP_001020774
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PREQMVEA 9
           PR+++VEA
Sbjct: 196 PRDELVEA 203
>NP_001001971
          Length = 487

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EPREQMVEA 9
          EP++Q VEA
Sbjct: 64 EPQQQNVEA 72
>NP_060899
          Length = 2624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2434 EPQRQQVEA 2442
>NP_937858
          Length = 585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EPREQMVEA 9
          EP++Q VEA
Sbjct: 64 EPQQQNVEA 72
>NP_000440
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PREQMVEA 9
           PR+++VEA
Sbjct: 196 PRDELVEA 203
>XP_006725524
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2434 EPQRQQVEA 2442
>XP_006725523
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2433 EPQRQQVEA 2441
>XP_005276828
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2434 EPQRQQVEA 2442
>XP_006726279
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2433 EPQRQQVEA 2441
>XP_005256921
          Length = 907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPREQMV 7
           EP EQMV
Sbjct: 246 EPNEQMV 252
>XP_005256920
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EPREQMV 7
           EP EQMV
Sbjct: 325 EPNEQMV 331
>XP_005269676
          Length = 486

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EPREQMVEA 9
          EP++Q VEA
Sbjct: 64 EPQQQNVEA 72
>XP_005269675
          Length = 584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EPREQMVEA 9
          EP++Q VEA
Sbjct: 64 EPQQQNVEA 72
>XP_006714722
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2434 EPQRQQVEA 2442
>XP_006714721
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EPREQMVEA 9
            EP+ Q VEA
Sbjct: 2433 EPQRQQVEA 2441
>XP_005245463
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PREQMVEA 9
           PR+++VEA
Sbjct: 196 PRDELVEA 203
>XP_005245462
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PREQMVEA 9
           PR+++VEA
Sbjct: 196 PRDELVEA 203
>NP_004371
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EPREQMVE 8
            EPR +M+E
Sbjct: 1016 EPRSEMME 1023
>NP_001073315
          Length = 2404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPREQMVE 8
           EPR +M+E
Sbjct: 978 EPRSEMME 985
>NP_001004334
          Length = 2367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   PREQMVE 8
           PRE+MV+
Sbjct: 638 PREEMVD 644
>XP_005255182
          Length = 2303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPREQMVE 8
           EPR +M+E
Sbjct: 877 EPRSEMME 884
>XP_006720911
          Length = 2355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EPREQMVE 8
            EPR +M+E
Sbjct: 1016 EPRSEMME 1023
>XP_005255181
          Length = 2427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EPREQMVE 8
            EPR +M+E
Sbjct: 1001 EPRSEMME 1008
>NP_001968
          Length = 957

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EPREQMVE 8
           +PREQ++E
Sbjct: 923 KPREQVLE 930
>NP_817092
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PREQMVEA 9
           P EQM+ A
Sbjct: 413 PEEQMISA 420
>NP_775885
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>NP_001004060
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>NP_001004067
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>NP_071941
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EPREQMV 7
           +PRE+MV
Sbjct: 250 KPREEMV 256
>XP_003846519
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EPREQMVEA 9
           EP E+M EA
Sbjct: 141 EPHEKMGEA 149
>XP_006725258
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>XP_006721059
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  EPREQMVE 8
          EP  QM+E
Sbjct: 8  EPSSQMIE 15
>XP_005255375
          Length = 1267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>XP_006719760
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 393 EPKEQLQKA 401
>XP_006719759
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 466 EPKEQLQKA 474
>XP_006719758
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 514 EPKEQLQKA 522
>XP_005254048
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 510 EPKEQLQKA 518
>XP_006719757
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 514 EPKEQLQKA 522
>XP_006710314
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  EPREQMVE 8
          EP  QM+E
Sbjct: 8  EPSSQMIE 15
>NP_997194
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           EP+EQ+ +A
Sbjct: 462 EPKEQLQKA 470
>NP_055102
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EPREQMVE 8
           EP  QM+E
Sbjct: 936 EPSSQMIE 943
>NP_008880
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 461 EPRERM 466
>NP_001258963
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 472 EPRERM 477
>NP_001120868
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 458 EPRERM 463
>NP_001130009
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PREQMVEA 9
           P EQ+VEA
Sbjct: 247 PVEQIVEA 254
>NP_055721
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EPREQMVEA 9
          EP  ++VEA
Sbjct: 48 EPEPELVEA 56
>NP_006011
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PREQMVE 8
           PR+ MVE
Sbjct: 314 PRDSMVE 320
>NP_005413
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    EPREQMV 7
            EP+EQ++
Sbjct: 2069 EPKEQII 2075
>NP_115725
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PREQMVEA 9
           P E++VEA
Sbjct: 184 PEEKLVEA 191
>XP_006722914
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 434 EPRERM 439
>XP_006721765
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 211 EPREKM 216
>XP_006721764
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 211 EPREKM 216
>XP_005271710
          Length = 2150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    EPREQMV 7
            EP+EQ++
Sbjct: 2064 EPKEQII 2070
>XP_005245315
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           E RE++VEA
Sbjct: 580 ENREKVVEA 588
>XP_006711447
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           E RE++VEA
Sbjct: 580 ENREKVVEA 588
>XP_005245314
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           E RE++VEA
Sbjct: 580 ENREKVVEA 588
>XP_006710450
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PREQMVEA 9
           P EQ+VEA
Sbjct: 262 PVEQIVEA 269
>NP_002637
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EPREQMVEA 9
           E RE++VEA
Sbjct: 580 ENREKVVEA 588
>NP_149124
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EPREQM 6
           EPRE+M
Sbjct: 231 EPREKM 236
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.118    0.300 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 652,902
Number of extensions: 1008
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package