Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              21     229
NP_001035957                                                           21     229
XP_006721990                                                           21     229
XP_006721989                                                           21     229
XP_005258041                                                           21     229
XP_006721988                                                           21     229
XP_006721987                                                           21     229
XP_006721986                                                           21     229
XP_005258040                                                           21     229
XP_006721985                                                           21     229
NP_057016                                                              19     665
NP_612354                                                              18    1482
XP_006713882                                                           18    1482
XP_006713881                                                           18    1482
NP_079353                                                              17    2528
XP_005270470                                                           17    2528
XP_005270469                                                           17    2528
NP_071881                                                              17    4312
XP_005264537                                                           17    4312
XP_006712136                                                           17    4312
NP_001265546                                                           16    5631
NP_001265545                                                           16    5631
NP_004327                                                              16    5631
NP_001136256                                                           16    5631
NP_071761                                                              16    5631
NP_001268661                                                           16    5631
NP_076983                                                              16    5631
NP_116564                                                              16    7355
NP_001093156                                                           16    7355
NP_001245283                                                           16    7355
NP_071336                                                              16    7355
NP_004238                                                              16    7355
NP_001245282                                                           16    7355
NP_001136077                                                           16    7355
NP_056002                                                              16    7355
NP_909119                                                              16    7355
NP_057537                                                              16    7355
XP_005262224                                                           16    7355
XP_005262223                                                           16    7355
XP_005262222                                                           16    7355
XP_006723412                                                           16    7355
XP_006723411                                                           16    7355
XP_006723410                                                           16    7355
XP_006723409                                                           16    7355
XP_006723408                                                           16    7355
XP_006714020                                                           16    7355
XP_005248200                                                           16    7355
XP_006714019                                                           16    7355
XP_005265280                                                           16    7355
XP_006713268                                                           16    7355
NP_115495                                                              15    9605
NP_001278253                                                           15    9605
NP_001244947                                                           15    9605
NP_758962                                                              15    9605
NP_001244946                                                           15    9605
NP_001103132                                                           15    9605
NP_690863                                                              15    9605
NP_001032203                                                           15    9605
NP_060474                                                              15    9605
NP_068579                                                              15    9605
NP_055184                                                              15    9605
XP_006722053                                                           15    9605
XP_006722052                                                           15    9605
XP_005274043                                                           15    9605
XP_006718611                                                           15    9605
XP_005250580                                                           15    9605
XP_005247626                                                           15    9605
XP_005247625                                                           15    9605
XP_006712480                                                           15    9605
XP_006712478                                                           15    9605
XP_006712127                                                           15    9605
NP_001034841                                                           15    9605
>NP_000258
          Length = 2818

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1898 EPHLTLEFL 1906
>NP_001035957
          Length = 2839

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1919 EPHLTLEFL 1927
>XP_006721990
          Length = 2823

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1929 EPHLTLEFL 1937
>XP_006721989
          Length = 2823

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1929 EPHLTLEFL 1937
>XP_005258041
          Length = 2836

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1898 EPHLTLEFL 1906
>XP_006721988
          Length = 2846

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1908 EPHLTLEFL 1916
>XP_006721987
          Length = 2849

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1929 EPHLTLEFL 1937
>XP_006721986
          Length = 2854

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1916 EPHLTLEFL 1924
>XP_005258040
          Length = 2857

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1919 EPHLTLEFL 1927
>XP_006721985
          Length = 2867

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EPHLMLEFL 9
            EPHL LEFL
Sbjct: 1929 EPHLTLEFL 1937
>NP_057016
          Length = 141

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EPHLMLEF 8
           EPHLM+E+
Sbjct: 129 EPHLMVEY 136
>NP_612354
          Length = 1242

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EPHLMLE 7
           +PHLMLE
Sbjct: 277 QPHLMLE 283
>XP_006713882
          Length = 1242

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EPHLMLE 7
           +PHLMLE
Sbjct: 277 QPHLMLE 283
>XP_006713881
          Length = 1024

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  EPHLMLE 7
          +PHLMLE
Sbjct: 58 QPHLMLE 64
>NP_079353
          Length = 510

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PHL LEF
Sbjct: 264 PHLTLEF 270
>XP_005270470
          Length = 464

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PHL LEF
Sbjct: 218 PHLTLEF 224
>XP_005270469
          Length = 516

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PHL LEF
Sbjct: 270 PHLTLEF 276
>NP_071881
          Length = 651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PHL+ EFL
Sbjct: 509 PHLIGEFL 516
>XP_005264537
          Length = 558

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PHL+ EFL
Sbjct: 509 PHLIGEFL 516
>XP_006712136
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PHL+ EFL
Sbjct: 509 PHLIGEFL 516
>NP_001265546
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  HLMLEFL 9
          HLM EFL
Sbjct: 51 HLMKEFL 57
>NP_001265545
          Length = 1065

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  HLMLEFL 9
          HLM EFL
Sbjct: 31 HLMKEFL 37
>NP_004327
          Length = 1085

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  HLMLEFL 9
          HLM EFL
Sbjct: 51 HLMKEFL 57
>NP_001136256
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           +PH +L+F
Sbjct: 249 QPHFLLKF 256
>NP_071761
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PHLMLE 7
           PHL+LE
Sbjct: 96  PHLLLE 101
>NP_001268661
          Length = 723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PHLMLE 7
           PHL+LE
Sbjct: 213 PHLLLE 218
>NP_076983
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EPHLMLEFL 9
           +P LM++FL
Sbjct: 286 QPTLMIDFL 294
>NP_116564
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 279 HLVLQFL 285
>NP_001093156
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 390 HLVLQFL 396
>NP_001245283
          Length = 962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PHLMLEFL 9
           PHL  EF+
Sbjct: 917 PHLAREFM 924
>NP_071336
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 390 HLVLQFL 396
>NP_004238
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PHLMLEFL 9
           PHL  EF+
Sbjct: 927 PHLAREFM 934
>NP_001245282
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PHLMLEFL 9
           PHL  EF+
Sbjct: 927 PHLAREFM 934
>NP_001136077
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PHLMLEFL 9
           PHL  EF+
Sbjct: 892 PHLAREFM 899
>NP_056002
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PHLMLEFL 9
            PH +L+FL
Sbjct: 1001 PHHILDFL 1008
>NP_909119
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 604 PHSVLKFL 611
>NP_057537
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 611 PHSVLKFL 618
>XP_005262224
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 216 HLVLQFL 222
>XP_005262223
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 216 HLVLQFL 222
>XP_005262222
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HLMLEFL 9
           HL+L+FL
Sbjct: 279 HLVLQFL 285
>XP_006723412
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           E HL+L+F
Sbjct: 475 EEHLVLQF 482
>XP_006723411
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           E HL+L+F
Sbjct: 494 EEHLVLQF 501
>XP_006723410
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           E HL+L+F
Sbjct: 494 EEHLVLQF 501
>XP_006723409
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           E HL+L+F
Sbjct: 505 EEHLVLQF 512
>XP_006723408
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EPHLMLEF 8
           E HL+L+F
Sbjct: 508 EEHLVLQF 515
>XP_006714020
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 966 PHHILDFL 973
>XP_005248200
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PHLMLEFL 9
            PH +L+FL
Sbjct: 1001 PHHILDFL 1008
>XP_006714019
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 973 PHHILDFL 980
>XP_005265280
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 533 PHSVLKFL 540
>XP_006713268
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PHLMLEFL 9
           PH +L+FL
Sbjct: 584 PHSVLKFL 591
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EPHLMLEFL 9
           +PH ++EF+
Sbjct: 885 DPHGIIEFV 893
>NP_001278253
          Length = 2639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PHLMLE 7
           PHLM++
Sbjct: 798 PHLMMQ 803
>NP_001244947
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           E H +LE+L
Sbjct: 229 ERHTLLEYL 237
>NP_758962
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           E H +LE+L
Sbjct: 229 ERHTLLEYL 237
>NP_001244946
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           E H +LE+L
Sbjct: 229 ERHTLLEYL 237
>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PHLMLEFL 9
            P++ LEFL
Sbjct: 4157 PYINLEFL 4164
>NP_690863
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           E H +LE+L
Sbjct: 207 ERHTLLEYL 215
>NP_001032203
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           +P L+LE L
Sbjct: 334 QPRLLLELL 342
>NP_060474
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  PHLML 6
          PHLML
Sbjct: 75 PHLML 79
>NP_068579
          Length = 974

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           +P L+LE L
Sbjct: 334 QPRLLLELL 342
>NP_055184
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PH +L+F
Sbjct: 109 PHTLLDF 115
>XP_006722053
          Length = 2608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PHLMLE 7
           PHLM++
Sbjct: 798 PHLMMQ 803
>XP_006722052
          Length = 2631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PHLMLE 7
           PHLM++
Sbjct: 798 PHLMMQ 803
>XP_005274043
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  PHLMLE 7
          PH++LE
Sbjct: 33 PHILLE 38
>XP_006718611
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  PHLMLE 7
          PH++LE
Sbjct: 33 PHILLE 38
>XP_005250580
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EPHLMLEFL 9
           +P L+LE L
Sbjct: 334 QPRLLLELL 342
>XP_005247626
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  PHLML 6
          PHLML
Sbjct: 91 PHLML 95
>XP_005247625
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  PHLML 6
          PHLML
Sbjct: 91 PHLML 95
>XP_006712480
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PH +L+F
Sbjct: 109 PHTLLDF 115
>XP_006712478
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PHLMLEF 8
           PH +L+F
Sbjct: 109 PHTLLDF 115
>XP_006712127
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    PHLMLEF 8
            PH +LEF
Sbjct: 1717 PHPILEF 1723
>NP_001034841
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  PHLMLE 7
          PH++LE
Sbjct: 33 PHILLE 38
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.151    0.469 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 713,572
Number of extensions: 1052
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package