Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           21     229
NP_055903                                                              21     229
NP_001093591                                                           17    2528
NP_001093590                                                           17    2528
NP_001032401                                                           17    2528
NP_055508                                                              17    2528
NP_003289                                                              17    3301
NP_001138890                                                           17    3301
XP_006724234                                                           17    3301
XP_005261462                                                           17    3301
XP_006714747                                                           17    3301
XP_006714745                                                           17    3301
XP_006713383                                                           17    3301
XP_005265485                                                           17    3301
NP_001257368                                                           16    5631
NP_005708                                                              16    5631
NP_056432                                                              16    5631
XP_005254357                                                           16    5631
NP_000319                                                              16    7355
NP_008995                                                              16    7355
NP_001019831                                                           16    7355
NP_065068                                                              16    7355
NP_055699                                                              16    7355
NP_001017392                                                           16    7355
NP_060733                                                              16    7355
NP_112240                                                              16    7355
XP_005272690                                                           16    7355
XP_006724601                                                           16    7355
XP_005252307                                                           16    7355
XP_006713877                                                           16    7355
XP_006713876                                                           16    7355
XP_006713875                                                           16    7355
XP_006713874                                                           16    7355
XP_006713873                                                           16    7355
XP_006712103                                                           16    7355
XP_006712102                                                           16    7355
XP_005245414                                                           16    7355
NP_001136273                                                           15    9605
NP_001136272                                                           15    9605
NP_005973                                                              15    9605
NP_938024                                                              15    9605
NP_004124                                                              15    9605
NP_036584                                                              15    9605
NP_060034                                                              15    9605
NP_078873                                                              15    9605
NP_001166988                                                           15    9605
NP_065803                                                              15    9605
NP_006258                                                              15    9605
NP_001166987                                                           15    9605
NP_001275882                                                           15    9605
NP_065191                                                              15    9605
NP_001275880                                                           15    9605
NP_004960                                                              15    9605
NP_149095                                                              15    9605
NP_001243359                                                           15    9605
XP_005262529                                                           15    9605
XP_006720342                                                           15    9605
XP_006719539                                                           15    9605
XP_005269826                                                           15    9605
XP_005269823                                                           15    9605
XP_005264064                                                           15    9605
XP_005264063                                                           15    9605
XP_005264062                                                           15    9605
XP_005264061                                                           15    9605
XP_005264060                                                           15    9605
XP_005264059                                                           15    9605
XP_005264497                                                           15    9605
XP_005264496                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ENTTDNSSA 9
           ENTTDN+SA
Sbjct: 213 ENTTDNNSA 221
>NP_055903
          Length = 1723

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ENTTDNSSA 9
           ENTTDN+SA
Sbjct: 213 ENTTDNNSA 221
>NP_001093591
          Length = 765

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           ENTT NSS+
Sbjct: 160 ENTTFNSSS 168
>NP_001093590
          Length = 811

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           ENTT NSS+
Sbjct: 206 ENTTFNSSS 214
>NP_001032401
          Length = 736

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           ENTT NSS+
Sbjct: 131 ENTTFNSSS 139
>NP_055508
          Length = 883

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           ENTT NSS+
Sbjct: 278 ENTTFNSSS 286
>NP_003289
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           NTTD+SS+
Sbjct: 340 NTTDSSSS 347
>NP_001138890
          Length = 2481

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ENTTDNSS 8
            ENT +NSS
Sbjct: 1267 ENTVENSS 1274
>XP_006724234
          Length = 2363

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ENTTDNSS 8
            ENT +NSS
Sbjct: 1149 ENTVENSS 1156
>XP_005261462
          Length = 2473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ENTTDNSS 8
            ENT +NSS
Sbjct: 1267 ENTVENSS 1274
>XP_006714747
          Length = 365

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ENTTDNS 7
           E+TTDNS
Sbjct: 355 ESTTDNS 361
>XP_006714745
          Length = 396

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ENTTDNS 7
           E+TTDNS
Sbjct: 386 ESTTDNS 392
>XP_006713383
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           NTTD+SS+
Sbjct: 340 NTTDSSSS 347
>XP_005265485
          Length = 596

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           NTTD+SS+
Sbjct: 321 NTTDSSSS 328
>NP_001257368
          Length = 154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E+ +DNSSA
Sbjct: 118 ESPSDNSSA 126
>NP_005708
          Length = 151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E+ +DNSSA
Sbjct: 115 ESPSDNSSA 123
>NP_056432
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           +NT  NSSA
Sbjct: 247 KNTNQNSSA 255
>XP_005254357
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           +NT  NSSA
Sbjct: 247 KNTNQNSSA 255
>NP_000319
          Length = 815

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           E T D+SSA
Sbjct: 684 ERTNDDSSA 692
>NP_008995
          Length = 1289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TDNSSA 9
           TDNSSA
Sbjct: 817 TDNSSA 822
>NP_001019831
          Length = 2986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2514 TDNSSA 2519
>NP_065068
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ENTTDNSS 8
           EN+T+NS+
Sbjct: 313 ENSTNNST 320
>NP_055699
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENTTDN 6
           EN+TDN
Sbjct: 808 ENSTDN 813
>NP_001017392
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENTTDN 6
           EN+TDN
Sbjct: 808 ENSTDN 813
>NP_060733
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    NTTDNSS 8
            NTT+NS+
Sbjct: 997  NTTENST 1003
>NP_112240
          Length = 153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           E  T+NSSA
Sbjct: 117 EKPTENSSA 125
>XP_005272690
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           E T D+SSA
Sbjct: 573 ERTNDDSSA 581
>XP_006724601
          Length = 1020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           E T D+SSA
Sbjct: 889 ERTNDDSSA 897
>XP_005252307
          Length = 153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENTTDNSSA 9
           E  T+NSSA
Sbjct: 117 EKPTENSSA 125
>XP_006713877
          Length = 2956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2484 TDNSSA 2489
>XP_006713876
          Length = 2966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2494 TDNSSA 2499
>XP_006713875
          Length = 2975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2503 TDNSSA 2508
>XP_006713874
          Length = 2979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2507 TDNSSA 2512
>XP_006713873
          Length = 2988

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TDNSSA 9
            TDNSSA
Sbjct: 2516 TDNSSA 2521
>XP_006712103
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTTDNSS 8
           NTT+NS+
Sbjct: 737 NTTENST 743
>XP_006712102
          Length = 1313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTTDNSS 8
           NTT+NS+
Sbjct: 875 NTTENST 881
>XP_005245414
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ENTTDNSS 8
           EN+T+NS+
Sbjct: 313 ENSTNNST 320
>NP_001136273
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENTTDN 6
           ENTTD+
Sbjct: 565 ENTTDD 570
>NP_001136272
          Length = 3144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENTTDN 6
           ENTTD+
Sbjct: 565 ENTTDD 570
>NP_005973
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           ENT +N+S+
Sbjct: 188 ENTENNNSS 196
>NP_938024
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENTTDN 6
           ENTTD+
Sbjct: 565 ENTTDD 570
>NP_004124
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  NTTDN 6
          NTTDN
Sbjct: 39 NTTDN 43
>NP_036584
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENTTDNS 7
           EN +DNS
Sbjct: 127 ENNSDNS 133
>NP_060034
          Length = 2551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NTTDN 6
           NTTDN
Sbjct: 619 NTTDN 623
>NP_078873
          Length = 876

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NTTDNSSA 9
           NTT  SSA
Sbjct: 849 NTTSRSSA 856
>NP_001166988
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NTTDNSSA 9
           NTT  SSA
Sbjct: 814 NTTSRSSA 821
>NP_065803
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENTTDNSS 8
           E TT+NS+
Sbjct: 841 EETTENST 848
>NP_006258
          Length = 3224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2701 ENTADN 2706
>NP_001166987
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NTTDNSSA 9
           NTT  SSA
Sbjct: 831 NTTSRSSA 838
>NP_001275882
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E TT+NS++
Sbjct: 181 EKTTNNSTS 189
>NP_065191
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E TT+NS++
Sbjct: 215 EKTTNNSTS 223
>NP_001275880
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E TT+NS++
Sbjct: 215 EKTTNNSTS 223
>NP_004960
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  TTDNSSA 9
          TTD SSA
Sbjct: 82 TTDKSSA 88
>NP_149095
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>NP_001243359
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>XP_005262529
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NTTDNSSA 9
           NTT  SSA
Sbjct: 848 NTTSRSSA 855
>XP_006720342
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NTTDNSSA 9
           ++TDNSS+
Sbjct: 188 DSTDNSSS 195
>XP_006719539
          Length = 2246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   NTTDN 6
           NTTDN
Sbjct: 619 NTTDN 623
>XP_005269826
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  TTDNSSA 9
          TTD SSA
Sbjct: 82 TTDKSSA 88
>XP_005269823
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  TTDNSSA 9
          TTD SSA
Sbjct: 82 TTDKSSA 88
>XP_005264064
          Length = 2282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 1751 ENTADN 1756
>XP_005264063
          Length = 3136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2605 ENTADN 2610
>XP_005264062
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2701 ENTADN 2706
>XP_005264061
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2701 ENTADN 2706
>XP_005264060
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2727 ENTADN 2732
>XP_005264059
          Length = 3258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    ENTTDN 6
            ENT DN
Sbjct: 2727 ENTADN 2732
>XP_005264497
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E TT+NS++
Sbjct: 215 EKTTNNSTS 223
>XP_005264496
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENTTDNSSA 9
           E TT+NS++
Sbjct: 96  EKTTNNSTS 104
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.268   0.0878    0.201 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 591,600
Number of extensions: 1389
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 19 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.3 bits)
S2: 28 (15.4 bits)

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