Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001119585                                                           18    1135
XP_006710233                                                           17    2528
NP_001106849                                                           17    4312
NP_060663                                                              17    4312
XP_006725230                                                           17    4312
XP_006720283                                                           17    4312
NP_065869                                                              17    4312
NP_001258596                                                           16    5631
NP_898861                                                              16    5631
NP_001258597                                                           16    5631
NP_115498                                                              16    5631
NP_001258598                                                           16    5631
NP_877963                                                              16    5631
NP_002651                                                              16    5631
NP_003195                                                              16    5631
NP_001010876                                                           16    5631
NP_002214                                                              16    5631
XP_005260495                                                           16    5631
XP_005260064                                                           16    5631
XP_005260063                                                           16    5631
XP_005260062                                                           16    5631
XP_005260061                                                           16    5631
XP_005257472                                                           16    5631
XP_005257470                                                           16    5631
XP_005257469                                                           16    5631
XP_005257468                                                           16    5631
XP_005257467                                                           16    5631
XP_006719127                                                           16    5631
XP_006715290                                                           16    5631
XP_006715289                                                           16    5631
XP_005249504                                                           16    5631
NP_000616                                                              16    7355
NP_003185                                                              16    7355
NP_004647                                                              16    7355
NP_060098                                                              16    7355
NP_001120680                                                           16    7355
NP_060661                                                              16    7355
NP_777577                                                              16    7355
NP_653271                                                              16    7355
NP_001230208                                                           16    7355
NP_060023                                                              16    7355
NP_001271245                                                           16    7355
NP_005112                                                              16    7355
NP_001120686                                                           16    7355
XP_006724749                                                           16    7355
XP_006724748                                                           16    7355
XP_006724747                                                           16    7355
XP_005262346                                                           16    7355
XP_005262345                                                           16    7355
XP_005262344                                                           16    7355
XP_006719906                                                           16    7355
XP_005266498                                                           16    7355
XP_006714306                                                           16    7355
XP_006714305                                                           16    7355
XP_005263139                                                           16    7355
NP_001074320                                                           16    7355
NP_149042                                                              16    7355
NP_997244                                                              15    9605
NP_835230                                                              15    9605
NP_055336                                                              15    9605
NP_003571                                                              15    9605
NP_001138244                                                           15    9605
XP_006724927                                                           15    9605
XP_005274836                                                           15    9605
XP_005274835                                                           15    9605
XP_006724506                                                           15    9605
XP_005274487                                                           15    9605
XP_005274486                                                           15    9605
XP_006722610                                                           15    9605
XP_005269890                                                           15    9605
NP_996892                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ENNVLSP 7
          ENNVLSP
Sbjct: 28 ENNVLSP 34
>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ENNVLSP 7
          ENNVLSP
Sbjct: 28 ENNVLSP 34
>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ENNVLSP 7
          ENNVLSP
Sbjct: 28 ENNVLSP 34
>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  ENNVLSP 7
          ENNVLSP
Sbjct: 28 ENNVLSP 34
>XP_006710233
          Length = 359

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ENNVLSPF 8
           +N VLSPF
Sbjct: 141 DNGVLSPF 148
>NP_001106849
          Length = 1328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NNVLSPFA 9
           NN LSPF+
Sbjct: 302 NNNLSPFS 309
>NP_060663
          Length = 1268

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NNVLSPFA 9
           NN LSPF+
Sbjct: 302 NNNLSPFS 309
>XP_006725230
          Length = 2636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ENNVLSPF 8
           ++N+LSPF
Sbjct: 750 QHNMLSPF 757
>XP_006720283
          Length = 2636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ENNVLSPF 8
           ++N+LSPF
Sbjct: 750 QHNMLSPF 757
>NP_065869
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ENNVLSPF 8
           ++N+LSPF
Sbjct: 572 QHNMLSPF 579
>NP_001258596
          Length = 270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 181 ENTVLSP 187
>NP_898861
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 262 ENTVLSP 268
>NP_001258597
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 245 ENTVLSP 251
>NP_115498
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 262 ENTVLSP 268
>NP_001258598
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 227 ENTVLSP 233
>NP_877963
          Length = 1290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ENNVLSPFA 9
            EN  LSPF+
Sbjct: 1216 ENGDLSPFS 1224
>NP_002651
          Length = 1291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ENNVLSPFA 9
            EN  LSPF+
Sbjct: 1217 ENGDLSPFS 1225
>NP_003195
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 293 QNNLLSP 299
>NP_001010876
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ENNVLSPF 8
          E NVL+PF
Sbjct: 43 ELNVLAPF 50
>NP_002214
          Length = 2701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ENNVLSP 7
            E+N+LSP
Sbjct: 1155 ESNILSP 1161
>XP_005260495
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ENNVLSPFA 9
            EN  LSPF+
Sbjct: 1256 ENGDLSPFS 1264
>XP_005260064
          Length = 1699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ENNVLSPFA 9
           EN V SP A
Sbjct: 637 ENGVFSPLA 645
>XP_005260063
          Length = 1756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ENNVLSPFA 9
           EN V SP A
Sbjct: 637 ENGVFSPLA 645
>XP_005260062
          Length = 1832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ENNVLSPFA 9
           EN V SP A
Sbjct: 637 ENGVFSPLA 645
>XP_005260061
          Length = 1889

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ENNVLSPFA 9
           EN V SP A
Sbjct: 637 ENGVFSPLA 645
>XP_005257472
          Length = 731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 252 QNNLLSP 258
>XP_005257470
          Length = 742

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 263 QNNLLSP 269
>XP_005257469
          Length = 742

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 263 QNNLLSP 269
>XP_005257468
          Length = 761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 282 QNNLLSP 288
>XP_005257467
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 293 QNNLLSP 299
>XP_006719127
          Length = 1865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ENNVLSP 7
            E+N+LSP
Sbjct: 1155 ESNILSP 1161
>XP_006715290
          Length = 249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 160 ENTVLSP 166
>XP_006715289
          Length = 249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 160 ENTVLSP 166
>XP_005249504
          Length = 338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ENNVLSP 7
           EN VLSP
Sbjct: 249 ENTVLSP 255
>NP_000616
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NNVLSPF 8
           N VLSPF
Sbjct: 482 NYVLSPF 488
>NP_003185
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ENNVLSPFA 9
          +NN L P+A
Sbjct: 3  QNNSLPPYA 11
>NP_004647
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ENNVLSPFA 9
           E+ VLSP A
Sbjct: 566 EDGVLSPLA 574
>NP_060098
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          E N LSPF
Sbjct: 10 EGNRLSPF 17
>NP_001120680
          Length = 2002

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          E N LSPF
Sbjct: 10 EGNRLSPF 17
>NP_060661
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 270 KNNLLSP 276
>NP_777577
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVLSPFA 9
           NVL+P+A
Sbjct: 539 NVLAPYA 545
>NP_653271
          Length = 1454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENNVLSPF 8
           +NN L+PF
Sbjct: 394 DNNGLAPF 401
>NP_001230208
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVLSPFA 9
           NVL+P+A
Sbjct: 539 NVLAPYA 545
>NP_060023
          Length = 1556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VLSPFA 9
           VLSPFA
Sbjct: 863 VLSPFA 868
>NP_001271245
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVLSPFA 9
           NVL+P+A
Sbjct: 274 NVLAPYA 280
>NP_005112
          Length = 2174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VLSPFA 9
            VLSPFA
Sbjct: 1346 VLSPFA 1351
>NP_001120686
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVLSPFA 9
           NVL+P+A
Sbjct: 539 NVLAPYA 545
>XP_006724749
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_006724748
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_006724747
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_005262346
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_005262345
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_005262344
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>XP_006719906
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  ENNVLSP 7
          +NN+LSP
Sbjct: 77 KNNLLSP 83
>XP_005266498
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ENNVLSP 7
           +NN+LSP
Sbjct: 270 KNNLLSP 276
>XP_006714306
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          E N LSPF
Sbjct: 10 EGNRLSPF 17
>XP_006714305
          Length = 1902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          E N LSPF
Sbjct: 10 EGNRLSPF 17
>XP_005263139
          Length = 2002

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          E N LSPF
Sbjct: 10 EGNRLSPF 17
>NP_001074320
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>NP_149042
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ENNVLSP 7
          ENN+L P
Sbjct: 25 ENNMLQP 31
>NP_997244
          Length = 3169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    ENNVLSPF 8
            EN +++PF
Sbjct: 1547 ENKLITPF 1554
>NP_835230
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>NP_055336
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VLSPFA 9
           +LSPFA
Sbjct: 635 ILSPFA 640
>NP_003571
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   ENNVLSPF 8
           E+NV++P+
Sbjct: 117 EHNVVAPY 124
>NP_001138244
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   ENNVLSPF 8
           E+NV++P+
Sbjct: 148 EHNVVAPY 155
>XP_006724927
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_005274836
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_005274835
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_006724506
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_005274487
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_005274486
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NNVLSPF 8
           NN L PF
Sbjct: 285 NNCLDPF 291
>XP_006722610
          Length = 1967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NNVLSPFA 9
           NNV+ P A
Sbjct: 301 NNVVKPLA 308
>XP_005269890
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          EN +L PF
Sbjct: 44 ENKLLHPF 51
>NP_996892
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  ENNVLSPF 8
          EN +L PF
Sbjct: 52 ENKLLHPF 59
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.127    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 773,393
Number of extensions: 1655
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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