Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055877                                                              18    1482
NP_001275656                                                           18    1482
XP_006717794                                                           18    1482
XP_005269715                                                           18    1482
XP_006717793                                                           18    1482
XP_005269713                                                           18    1482
NP_919290                                                              17    3301
NP_149985                                                              17    3301
NP_006724                                                              17    3301
XP_005262168                                                           17    3301
NP_004713                                                              17    4312
XP_006716238                                                           17    4312
XP_005250746                                                           17    4312
NP_004481                                                              16    5631
NP_055865                                                              16    5631
XP_006715091                                                           16    5631
XP_005249012                                                           16    5631
XP_006712520                                                           16    5631
XP_005246534                                                           16    5631
NP_689846                                                              16    7355
NP_001018123                                                           16    7355
NP_079198                                                              16    7355
NP_001172106                                                           16    7355
NP_001138923                                                           16    7355
NP_004678                                                              16    7355
XP_006722231                                                           16    7355
XP_005257843                                                           16    7355
XP_005257842                                                           16    7355
XP_005257841                                                           16    7355
NP_000029                                                              15    9605
NP_001120983                                                           15    9605
NP_001120982                                                           15    9605
NP_001836                                                              15    9605
NP_003144                                                              15    9605
NP_006294                                                              15    9605
NP_001171549                                                           15    9605
NP_001171550                                                           15    9605
NP_116195                                                              15    9605
NP_758519                                                              15    9605
NP_000751                                                              15    9605
NP_724781                                                              15    9605
NP_055608                                                              15    9605
NP_001171551                                                           15    9605
NP_001171552                                                           15    9605
NP_001020368                                                           15    9605
XP_006719638                                                           15    9605
XP_006719637                                                           15    9605
XP_006719636                                                           15    9605
XP_006716845                                                           15    9605
XP_005251541                                                           15    9605
XP_006716843                                                           15    9605
XP_005251540                                                           15    9605
XP_005249907                                                           15    9605
XP_006715835                                                           15    9605
XP_005249905                                                           15    9605
XP_005249904                                                           15    9605
XP_006713424                                                           15    9605
XP_005265572                                                           15    9605
XP_005270552                                                           15    9605
XP_005270550                                                           15    9605
XP_005270549                                                           15    9605
NP_003991                                                              15    9605
>NP_055877
          Length = 1664

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>NP_001275656
          Length = 1400

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>XP_006717794
          Length = 1194

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>XP_005269715
          Length = 1230

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>XP_006717793
          Length = 1603

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>XP_005269713
          Length = 1646

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           EN+SPF S+
Sbjct: 141 ENLSPFDSI 149
>NP_919290
          Length = 909

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF S
Sbjct: 177 ENVAPFHS 184
>NP_149985
          Length = 549

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           EN+ PFR
Sbjct: 151 ENVEPFR 157
>NP_006724
          Length = 756

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           EN+ PFR
Sbjct: 212 ENVKPFR 218
>XP_005262168
          Length = 756

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           EN+ PFR
Sbjct: 212 ENVKPFR 218
>NP_004713
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  ENISPF 6
          EN+SPF
Sbjct: 72 ENVSPF 77
>XP_006716238
          Length = 419

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  ENISPF 6
          EN+SPF
Sbjct: 79 ENVSPF 84
>XP_005250746
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  ENISPF 6
          EN+SPF
Sbjct: 79 ENVSPF 84
>NP_004481
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           ++ISP RS+
Sbjct: 363 QSISPMRSI 371
>NP_055865
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           ENIS FR+
Sbjct: 340 ENISAFRN 347
>XP_006715091
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           ENIS FR+
Sbjct: 284 ENISAFRN 291
>XP_005249012
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           ENIS FR+
Sbjct: 340 ENISAFRN 347
>XP_006712520
          Length = 340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           ++ISP RS+
Sbjct: 163 QSISPMRSI 171
>XP_005246534
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ENISPFRSV 9
           ++ISP RS+
Sbjct: 276 QSISPMRSI 284
>NP_689846
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI P+R
Sbjct: 807 ENIHPYR 813
>NP_001018123
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI P+R
Sbjct: 807 ENIHPYR 813
>NP_079198
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENISPF 6
           ENI+PF
Sbjct: 211 ENIAPF 216
>NP_001172106
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ENISPF 6
           ENI+PF
Sbjct: 211 ENIAPF 216
>NP_001138923
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SPFRSV 9
           SPFRS+
Sbjct: 140 SPFRSI 145
>NP_004678
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++ FRS
Sbjct: 205 ENVASFRS 212
>XP_006722231
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++ FRS
Sbjct: 205 ENVASFRS 212
>XP_005257843
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++ FRS
Sbjct: 205 ENVASFRS 212
>XP_005257842
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++ FRS
Sbjct: 209 ENVASFRS 216
>XP_005257841
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++ FRS
Sbjct: 219 ENVASFRS 226
>NP_000029
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ENISPFRS 8
            E +SP+RS
Sbjct: 1097 ECVSPYRS 1104
>NP_001120983
          Length = 2825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ENISPFRS 8
            E +SP+RS
Sbjct: 1079 ECVSPYRS 1086
>NP_001120982
          Length = 2843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ENISPFRS 8
            E +SP+RS
Sbjct: 1097 ECVSPYRS 1104
>NP_001836
          Length = 1669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    ENISPFRS 8
            ENI PF S
Sbjct: 1539 ENIRPFIS 1546
>NP_003144
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>NP_006294
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF +
Sbjct: 307 ENLAPFNT 314
>NP_001171549
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>NP_001171550
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>NP_116195
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 548 ENIKPF 553
>NP_758519
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 492 ENIRPFQ 498
>NP_000751
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 492 ENIRPFQ 498
>NP_724781
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 492 ENIRPFQ 498
>NP_055608
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 288 ENIEPF 293
>NP_001171551
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 477 ENIQPF 482
>NP_001171552
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 477 ENIQPF 482
>NP_001020368
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  ENISPF 6
          ENI PF
Sbjct: 39 ENIDPF 44
>XP_006719638
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>XP_006719637
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>XP_006719636
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 587 ENIQPF 592
>XP_006716845
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ISPFRS 8
           +SPFRS
Sbjct: 185 LSPFRS 190
>XP_005251541
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ISPFRS 8
           +SPFRS
Sbjct: 185 LSPFRS 190
>XP_006716843
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ISPFRS 8
           +SPFRS
Sbjct: 185 LSPFRS 190
>XP_005251540
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ISPFRS 8
           +SPFRS
Sbjct: 185 LSPFRS 190
>XP_005249907
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF +
Sbjct: 229 ENLAPFNT 236
>XP_006715835
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF +
Sbjct: 263 ENLAPFNT 270
>XP_005249905
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF +
Sbjct: 267 ENLAPFNT 274
>XP_005249904
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ENISPFRS 8
           EN++PF +
Sbjct: 300 ENLAPFNT 307
>XP_006713424
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 548 ENIKPF 553
>XP_005265572
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   ENISPF 6
           ENI PF
Sbjct: 548 ENIKPF 553
>XP_005270552
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 360 ENIRPFQ 366
>XP_005270550
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 492 ENIRPFQ 498
>XP_005270549
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ENISPFR 7
           ENI PF+
Sbjct: 470 ENIRPFQ 476
>NP_003991
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  ENISPF 6
          ENI PF
Sbjct: 49 ENIDPF 54
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.132    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,930
Number of extensions: 504
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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