Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     509
NP_056377                                                              18    1482
NP_061939                                                              18    1935
NP_065915                                                              17    2528
XP_005246765                                                           17    2528
NP_003676                                                              17    3301
XP_005259725                                                           17    3301
NP_115979                                                              17    4312
NP_001005366                                                           17    4312
XP_005254013                                                           17    4312
XP_005254012                                                           17    4312
XP_005254011                                                           17    4312
NP_055448                                                              17    4312
NP_001275582                                                           16    5631
NP_004850                                                              16    5631
NP_009029                                                              16    5631
NP_001826                                                              16    5631
NP_001005333                                                           16    5631
NP_001005332                                                           16    5631
XP_006724391                                                           16    5631
XP_005261338                                                           16    5631
XP_005277858                                                           16    5631
XP_006724390                                                           16    5631
XP_006724389                                                           16    5631
XP_005277857                                                           16    5631
XP_005257069                                                           16    5631
NP_008917                                                              16    5631
NP_079197                                                              16    7355
NP_803879                                                              16    7355
NP_803881                                                              16    7355
NP_001258992                                                           16    7355
NP_110428                                                              16    7355
NP_001229291                                                           16    7355
NP_001258991                                                           16    7355
NP_001092270                                                           16    7355
NP_001258990                                                           16    7355
NP_001099001                                                           16    7355
NP_065870                                                              16    7355
NP_001156001                                                           16    7355
XP_005262260                                                           16    7355
XP_005262259                                                           16    7355
XP_006724671                                                           16    7355
XP_006724670                                                           16    7355
XP_005248808                                                           16    7355
XP_005248807                                                           16    7355
XP_005248806                                                           16    7355
XP_005248805                                                           16    7355
XP_005248804                                                           16    7355
XP_005248803                                                           16    7355
XP_005248802                                                           16    7355
XP_005248801                                                           16    7355
XP_005248800                                                           16    7355
NP_001245                                                              15    9605
NP_477352                                                              15    9605
NP_002641                                                              15    9605
XP_005261692                                                           15    9605
XP_005261691                                                           15    9605
XP_006717377                                                           15    9605
XP_006717376                                                           15    9605
XP_005272289                                                           15    9605
XP_006717375                                                           15    9605
XP_006716779                                                           15    9605
NP_003925                                                              15    9605
NP_000929                                                              15    9605
>NP_005179
          Length = 906

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           EM KNILRE
Sbjct: 886 EMAKNILRE 894
>NP_056377
          Length = 489

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKNI+RE
Sbjct: 191 EAVKNIIRE 199
>NP_061939
          Length = 1249

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EMVKNILRE 9
            EMVK ILRE
Sbjct: 1045 EMVKVILRE 1053
>NP_065915
          Length = 653

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           EMV NILR+
Sbjct: 247 EMVGNILRD 255
>XP_005246765
          Length = 653

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           EMV NILR+
Sbjct: 247 EMVGNILRD 255
>NP_003676
          Length = 711

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           EMV +ILRE
Sbjct: 297 EMVMDILRE 305
>XP_005259725
          Length = 747

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           EMV +ILRE
Sbjct: 297 EMVMDILRE 305
>NP_115979
          Length = 1336

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKN+L+E
Sbjct: 546 EGVKNVLKE 554
>NP_001005366
          Length = 1265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKN+L+E
Sbjct: 515 EGVKNVLKE 523
>XP_005254013
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKN+L+E
Sbjct: 509 EGVKNVLKE 517
>XP_005254012
          Length = 1305

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKN+L+E
Sbjct: 515 EGVKNVLKE 523
>XP_005254011
          Length = 1334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           E VKN+L+E
Sbjct: 546 EGVKNVLKE 554
>NP_055448
          Length = 1173

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           ++ KNILRE
Sbjct: 518 KLYKNILRE 526
>NP_001275582
          Length = 1679

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 761 ERVKNFLKE 769
>NP_004850
          Length = 1675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 757 ERVKNFLKE 765
>NP_009029
          Length = 1640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 757 ERVKNFLKE 765
>NP_001826
          Length = 1583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 757 ERVKNFLKE 765
>NP_001005333
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           EM+++I+RE
Sbjct: 552 EMLRDIIRE 560
>NP_001005332
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           EM+++I+RE
Sbjct: 496 EMLRDIIRE 504
>XP_006724391
          Length = 1567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 778 ERVKNFLKE 786
>XP_005261338
          Length = 1570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 778 ERVKNFLKE 786
>XP_005277858
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 778 ERVKNFLKE 786
>XP_006724390
          Length = 1623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 740 ERVKNFLKE 748
>XP_006724389
          Length = 1653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 778 ERVKNFLKE 786
>XP_005277857
          Length = 1661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 778 ERVKNFLKE 786
>XP_005257069
          Length = 1682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           E VKN L+E
Sbjct: 757 ERVKNFLKE 765
>NP_008917
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           EM+++I+RE
Sbjct: 496 EMLRDIIRE 504
>NP_079197
          Length = 589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMVKN+  E
Sbjct: 462 EMVKNLRME 470
>NP_803879
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_803881
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001258992
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_110428
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001229291
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001258991
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001092270
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001258990
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>NP_001099001
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1257 EMIHNLLR 1264
>NP_065870
          Length = 1302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1240 EMIHNLLR 1247
>NP_001156001
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1453 EMIHNLLR 1460
>XP_005262260
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMVKN+  E
Sbjct: 447 EMVKNLRME 455
>XP_005262259
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMVKN+  E
Sbjct: 462 EMVKNLRME 470
>XP_006724671
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>XP_006724670
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EMVKNILRE 9
           +M+K+++RE
Sbjct: 438 DMLKDVIRE 446
>XP_005248808
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1059 EMIHNLLR 1066
>XP_005248807
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1120 EMIHNLLR 1127
>XP_005248806
          Length = 1317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1255 EMIHNLLR 1262
>XP_005248805
          Length = 1345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1283 EMIHNLLR 1290
>XP_005248804
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1316 EMIHNLLR 1323
>XP_005248803
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1393 EMIHNLLR 1400
>XP_005248802
          Length = 1515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1453 EMIHNLLR 1460
>XP_005248801
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1479 EMIHNLLR 1486
>XP_005248800
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EMVKNILR 8
            EM+ N+LR
Sbjct: 1479 EMIHNLLR 1486
>NP_001245
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EMVKNILRE 9
           ++++N LRE
Sbjct: 180 DVIRNFLRE 188
>NP_477352
          Length = 2102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VKNILRE 9
            ++N+LRE
Sbjct: 1370 IRNVLRE 1376
>NP_002641
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VKNILRE 9
           ++N+LRE
Sbjct: 122 IRNVLRE 128
>XP_005261692
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VKNILRE 9
            ++N+LRE
Sbjct: 1398 IRNVLRE 1404
>XP_005261691
          Length = 2099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VKNILRE 9
            ++N+LRE
Sbjct: 1367 IRNVLRE 1373
>XP_006717377
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EMVKNILRE 9
          EMV  I+RE
Sbjct: 31 EMVLEIIRE 39
>XP_006717376
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMV  I+RE
Sbjct: 139 EMVLEIIRE 147
>XP_005272289
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMV  I+RE
Sbjct: 226 EMVLEIIRE 234
>XP_006717375
          Length = 571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMV  I+RE
Sbjct: 225 EMVLEIIRE 233
>XP_006716779
          Length = 2399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    KNILRE 9
            KN+LRE
Sbjct: 1156 KNVLRE 1161
>NP_003925
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EMVKNILRE 9
           EMV  I+RE
Sbjct: 226 EMVLEIIRE 234
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MVKNILRE 9
           M KN+L+E
Sbjct: 407 MFKNLLKE 414
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.135    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,417
Number of extensions: 780
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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