Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              19     665
XP_006714104                                                           19     665
XP_005265800                                                           19     665
XP_006714103                                                           19     665
XP_006714102                                                           19     665
NP_002178                                                              17    3301
NP_001186068                                                           17    4312
NP_067032                                                              17    4312
NP_001186067                                                           17    4312
NP_112572                                                              17    4312
NP_004357                                                              16    7355
NP_001164560                                                           16    7355
NP_001164559                                                           16    7355
NP_001164558                                                           16    7355
NP_006511                                                              16    7355
XP_006713552                                                           16    7355
XP_006713551                                                           16    7355
NP_001186566                                                           15    9605
NP_001109                                                              15    9605
NP_001186564                                                           15    9605
NP_001186565                                                           15    9605
NP_005692                                                              15    9605
NP_001103224                                                           15    9605
NP_001036053                                                           15    9605
NP_001036046                                                           15    9605
XP_006719593                                                           15    9605
XP_006719591                                                           15    9605
XP_006715710                                                           15    9605
XP_006715709                                                           15    9605
XP_006715708                                                           15    9605
>NP_006197
          Length = 1089

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           E IVVTCAV
Sbjct: 229 ETIVVTCAV 237
>XP_006714104
          Length = 832

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           E IVVTCAV
Sbjct: 254 ETIVVTCAV 262
>XP_005265800
          Length = 1089

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           E IVVTCAV
Sbjct: 229 ETIVVTCAV 237
>XP_006714103
          Length = 1111

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           E IVVTCAV
Sbjct: 251 ETIVVTCAV 259
>XP_006714102
          Length = 1114

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           E IVVTCAV
Sbjct: 254 ETIVVTCAV 262
>NP_002178
          Length = 328

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM+V+TC
Sbjct: 44 EMVVLTC 50
>NP_001186068
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IVVTCAV 9
           +V+TCA+
Sbjct: 341 VVITCAI 347
>NP_067032
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IVVTCAV 9
           +V+TCA+
Sbjct: 341 VVITCAI 347
>NP_001186067
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IVVTCAV 9
           +V+TCA+
Sbjct: 341 VVITCAI 347
>NP_112572
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EMIVVTCAV 9
           EM+V+ C+V
Sbjct: 304 EMLVLVCSV 312
>NP_004357
          Length = 898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 238 EMLAAACAV 246
>NP_001164560
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 238 EMLAAACAV 246
>NP_001164559
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 194 EMLAAACAV 202
>NP_001164558
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 238 EMLAAACAV 246
>NP_006511
          Length = 116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VVTCAV 9
          +VTCAV
Sbjct: 65 IVTCAV 70
>XP_006713552
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 238 EMLAAACAV 246
>XP_006713551
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           EM+   CAV
Sbjct: 212 EMLAAACAV 220
>NP_001186566
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>NP_001109
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>NP_001186564
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>NP_001186565
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>NP_005692
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           E IVV C V
Sbjct: 118 EWIVVVCPV 126
>NP_001103224
          Length = 2215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2  MIVVTCAV 9
          M+++TC +
Sbjct: 7  MVILTCLI 14
>NP_001036053
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           E IVV C V
Sbjct: 118 EWIVVVCPV 126
>NP_001036046
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EMIVVTCAV 9
           E IVV C V
Sbjct: 118 EWIVVVCPV 126
>XP_006719593
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2  MIVVTCAV 9
          M+++TC +
Sbjct: 7  MVILTCLI 14
>XP_006719591
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2  MIVVTCAV 9
          M+++TC +
Sbjct: 7  MVILTCLI 14
>XP_006715710
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>XP_006715709
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
>XP_006715708
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EMIVVTC 7
          EM++V+C
Sbjct: 71 EMVLVSC 77
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.135    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 504,247
Number of extensions: 388
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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