Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              19     665
NP_113655                                                              17    3301
NP_001245357                                                           17    3301
XP_006714863                                                           17    3301
XP_005268578                                                           17    3301
NP_775869                                                              17    4312
XP_006719420                                                           17    4312
NP_115763                                                              16    5631
NP_001171600                                                           16    5631
NP_036563                                                              16    5631
NP_001245355                                                           16    5631
XP_006722083                                                           16    5631
XP_005257654                                                           16    5631
XP_005257653                                                           16    5631
XP_005257652                                                           16    5631
XP_006717307                                                           16    5631
XP_006717306                                                           16    5631
XP_006717305                                                           16    5631
XP_005266153                                                           16    5631
XP_006717304                                                           16    5631
XP_006714862                                                           16    5631
NP_003077                                                              16    5631
NP_000283                                                              16    7355
NP_003593                                                              16    7355
NP_001268233                                                           16    7355
NP_001128683                                                           16    7355
XP_006724561                                                           16    7355
XP_005274607                                                           16    7355
XP_005274605                                                           16    7355
XP_006724560                                                           16    7355
XP_006724559                                                           16    7355
XP_006716216                                                           16    7355
XP_005250700                                                           16    7355
XP_006716215                                                           16    7355
NP_001014301                                                           16    7355
NP_694972                                                              15    9605
NP_733749                                                              15    9605
NP_056254                                                              15    9605
NP_056013                                                              15    9605
NP_001139679                                                           15    9605
NP_001139678                                                           15    9605
NP_001139677                                                           15    9605
NP_001139676                                                           15    9605
NP_001139675                                                           15    9605
NP_001193762                                                           15    9605
NP_874369                                                              15    9605
NP_006379                                                              15    9605
NP_874368                                                              15    9605
NP_002579                                                              15    9605
NP_115778                                                              15    9605
XP_006718484                                                           15    9605
XP_005271814                                                           15    9605
XP_005271810                                                           15    9605
XP_005271808                                                           15    9605
XP_005271807                                                           15    9605
NP_001139674                                                           15    9605
>NP_004110
          Length = 993

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   EMDLGLLS 8
           EMDLGLLS
Sbjct: 978 EMDLGLLS 985
>NP_113655
          Length = 959

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MDLGLLSA 9
           MDLGL++A
Sbjct: 570 MDLGLINA 577
>NP_001245357
          Length = 983

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MDLGLLSA 9
           MDLGL++A
Sbjct: 594 MDLGLINA 601
>XP_006714863
          Length = 921

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MDLGLLSA 9
           MDLGL++A
Sbjct: 532 MDLGLINA 539
>XP_005268578
          Length = 959

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   MDLGLLSA 9
           MDLGL++A
Sbjct: 570 MDLGLINA 577
>NP_775869
          Length = 921

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMDLGLLSA 9
           EM+L LLSA
Sbjct: 605 EMNLSLLSA 613
>XP_006719420
          Length = 949

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EMDLGLLSA 9
           EM+L LLSA
Sbjct: 634 EMNLSLLSA 642
>NP_115763
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  MDLGLLSA 9
          +DLGLLS+
Sbjct: 65 VDLGLLSS 72
>NP_001171600
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EMDLGLL 7
           +MDLGLL
Sbjct: 574 KMDLGLL 580
>NP_036563
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EMDLGLL 7
           +MDLGLL
Sbjct: 634 KMDLGLL 640
>NP_001245355
          Length = 945

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EMDLGLLSA 9
           ++DLGL++A
Sbjct: 555 DIDLGLINA 563
>XP_006722083
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  MDLGLLSA 9
          +DLGLLS+
Sbjct: 65 VDLGLLSS 72
>XP_005257654
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  MDLGLLSA 9
          +DLGLLS+
Sbjct: 65 VDLGLLSS 72
>XP_005257653
          Length = 1242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  MDLGLLSA 9
          +DLGLLS+
Sbjct: 65 VDLGLLSS 72
>XP_005257652
          Length = 1279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  MDLGLLSA 9
          +DLGLLS+
Sbjct: 65 VDLGLLSS 72
>XP_006717307
          Length = 873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MDLGLLS 8
           +DLGLLS
Sbjct: 673 LDLGLLS 679
>XP_006717306
          Length = 1441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    MDLGLLS 8
            +DLGLLS
Sbjct: 1241 LDLGLLS 1247
>XP_006717305
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    MDLGLLS 8
            +DLGLLS
Sbjct: 1269 LDLGLLS 1275
>XP_005266153
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    MDLGLLS 8
            +DLGLLS
Sbjct: 1269 LDLGLLS 1275
>XP_006717304
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    MDLGLLS 8
            +DLGLLS
Sbjct: 1269 LDLGLLS 1275
>XP_006714862
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   EMDLGLLSA 9
           ++DLGL++A
Sbjct: 566 DIDLGLINA 574
>NP_003077
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    MDLGLLS 8
            +DLGLLS
Sbjct: 1269 LDLGLLS 1275
>NP_000283
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           E+D GLLS
Sbjct: 254 EIDAGLLS 261
>NP_003593
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MDLGLLS 8
           M+LGLLS
Sbjct: 95  MELGLLS 101
>NP_001268233
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 65 MELGLLS 71
>NP_001128683
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 90 MELGLLS 96
>XP_006724561
          Length = 1061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EMDLGLLS 8
          E+D GLLS
Sbjct: 72 EIDAGLLS 79
>XP_005274607
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           E+D GLLS
Sbjct: 254 EIDAGLLS 261
>XP_005274605
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           E+D GLLS
Sbjct: 254 EIDAGLLS 261
>XP_006724560
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           E+D GLLS
Sbjct: 254 EIDAGLLS 261
>XP_006724559
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           E+D GLLS
Sbjct: 254 EIDAGLLS 261
>XP_006716216
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 90 MELGLLS 96
>XP_005250700
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MDLGLLS 8
           M+LGLLS
Sbjct: 95  MELGLLS 101
>XP_006716215
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MDLGLLS 8
           M+LGLLS
Sbjct: 95  MELGLLS 101
>NP_001014301
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DLGLLSA 9
          DLGLLS+
Sbjct: 53 DLGLLSS 59
>NP_694972
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 955 DLGLLS 960
>NP_733749
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_056254
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EMDLGLLS 8
           EM+ GLLS
Sbjct: 177 EMERGLLS 184
>NP_056013
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    DLGLLS 8
            DLGLLS
Sbjct: 1197 DLGLLS 1202
>NP_001139679
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_001139678
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_001139677
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_001139676
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_001139675
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
>NP_001193762
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 389 DLGLLS 394
>NP_874369
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 441 DLGLLS 446
>NP_006379
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 408 DLGLLS 413
>NP_874368
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 356 DLGLLS 361
>NP_002579
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  MDLGLLSA 9
          +DLG LSA
Sbjct: 56 LDLGSLSA 63
>NP_115778
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  MDLGLLSA 9
          +DLG LSA
Sbjct: 56 LDLGSLSA 63
>XP_006718484
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 417 DLGLLS 422
>XP_005271814
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   DLGLLS 8
           DLGLLS
Sbjct: 983 DLGLLS 988
>XP_005271810
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    DLGLLS 8
            DLGLLS
Sbjct: 1212 DLGLLS 1217
>XP_005271808
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    DLGLLS 8
            DLGLLS
Sbjct: 1254 DLGLLS 1259
>XP_005271807
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    DLGLLS 8
            DLGLLS
Sbjct: 1269 DLGLLS 1274
>NP_001139674
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MDLGLLS 8
          M+LGLLS
Sbjct: 46 MNLGLLS 52
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.136    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 466,350
Number of extensions: 626
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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