Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              18    1135
NP_061122                                                              16    5631
NP_898884                                                              16    5631
NP_001138696                                                           16    5631
NP_001157876                                                           16    5631
XP_006720716                                                           16    5631
XP_006720715                                                           16    5631
XP_006720669                                                           16    5631
XP_006720668                                                           16    5631
XP_006720667                                                           16    5631
XP_006713666                                                           16    5631
XP_006713665                                                           16    5631
NP_001033729                                                           16    5631
NP_000630                                                              16    7355
NP_055281                                                              16    7355
NP_073594                                                              16    7355
NP_065897                                                              16    7355
XP_005248178                                                           16    7355
XP_005247773                                                           16    7355
XP_005247772                                                           16    7355
XP_006713795                                                           16    7355
XP_005247771                                                           16    7355
XP_005247770                                                           16    7355
XP_005247769                                                           16    7355
XP_006713794                                                           16    7355
XP_005247767                                                           16    7355
XP_005270810                                                           16    7355
NP_127493                                                              15    9605
NP_127494                                                              15    9605
NP_001157108                                                           15    9605
NP_001129476                                                           15    9605
NP_001509                                                              15    9605
NP_127492                                                              15    9605
NP_001116203                                                           15    9605
NP_056056                                                              15    9605
NP_001245389                                                           15    9605
NP_001245388                                                           15    9605
NP_006204                                                              15    9605
NP_065744                                                              15    9605
XP_005261319                                                           15    9605
XP_006724151                                                           15    9605
XP_006724150                                                           15    9605
XP_006724149                                                           15    9605
XP_006724148                                                           15    9605
XP_006724147                                                           15    9605
XP_006724146                                                           15    9605
XP_006724145                                                           15    9605
XP_006724144                                                           15    9605
XP_005250353                                                           15    9605
XP_006716008                                                           15    9605
XP_006716007                                                           15    9605
XP_006716006                                                           15    9605
XP_006716005                                                           15    9605
XP_006716004                                                           15    9605
XP_006716003                                                           15    9605
XP_006716002                                                           15    9605
XP_005250348                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ELREATS K
Sbjct: 746 ELREATSPK 754
>NP_061122
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>NP_898884
          Length = 1177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           LR+ATS+K
Sbjct: 428 LRDATSTK 435
>NP_001138696
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>NP_001157876
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>XP_006720716
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>XP_006720715
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>XP_006720669
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 397 ESREATSS 404
>XP_006720668
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 517 ESREATSS 524
>XP_006720667
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 517 ESREATSS 524
>XP_006713666
          Length = 1104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           LR+ATS+K
Sbjct: 355 LRDATSTK 362
>XP_006713665
          Length = 1175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           LR+ATS+K
Sbjct: 428 LRDATSTK 435
>NP_001033729
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ELREATSS 8
           E REATSS
Sbjct: 526 ESREATSS 533
>NP_000630
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELREATS 7
           ELRE+TS
Sbjct: 113 ELRESTS 119
>NP_055281
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELREATS 7
           ELREAT+
Sbjct: 238 ELREATA 244
>NP_073594
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 353 QIREATSER 361
>NP_065897
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ELREATS 7
          ELR+ATS
Sbjct: 90 ELRDATS 96
>XP_005248178
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ELREATS 7
          ELR+ATS
Sbjct: 90 ELRDATS 96
>XP_005247773
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 394 QIREATSER 402
>XP_005247772
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 394 QIREATSER 402
>XP_006713795
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 194 QIREATSER 202
>XP_005247771
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 194 QIREATSER 202
>XP_005247770
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 194 QIREATSER 202
>XP_005247769
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 194 QIREATSER 202
>XP_006713794
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 394 QIREATSER 402
>XP_005247767
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELREATSSK 9
           ++REATS +
Sbjct: 394 QIREATSER 402
>XP_005270810
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELREATS 7
           ELREAT+
Sbjct: 238 ELREATA 244
>NP_127493
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 795 IKESTSSK 802
>NP_127494
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 794 IKESTSSK 801
>NP_001157108
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 793 IKESTSSK 800
>NP_001129476
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>NP_001509
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 774 IKESTSSK 781
>NP_127492
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 815 IKESTSSK 822
>NP_001116203
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>NP_056056
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>NP_001245389
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ELREAT 6
          ELREAT
Sbjct: 66 ELREAT 71
>NP_001245388
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ELREAT 6
          ELREAT
Sbjct: 66 ELREAT 71
>NP_006204
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ELREAT 6
          ELREAT
Sbjct: 66 ELREAT 71
>NP_065744
          Length = 2113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ELREAT 6
            ELREAT
Sbjct: 1600 ELREAT 1605
>XP_005261319
          Length = 2002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724151
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724150
          Length = 2154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724149
          Length = 2168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724148
          Length = 2176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724147
          Length = 2187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724146
          Length = 2193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724145
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_006724144
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ELREAT 6
           ELREAT
Sbjct: 277 ELREAT 282
>XP_005250353
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 786 IKESTSSK 793
>XP_006716008
          Length = 988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 805 IKESTSSK 812
>XP_006716007
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 806 IKESTSSK 813
>XP_006716006
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 807 IKESTSSK 814
>XP_006716005
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 815 IKESTSSK 822
>XP_006716004
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 820 IKESTSSK 827
>XP_006716003
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 826 IKESTSSK 833
>XP_006716002
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 827 IKESTSSK 834
>XP_005250348
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LREATSSK 9
           ++E+TSSK
Sbjct: 827 IKESTSSK 834
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.284   0.0997    0.214 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 348,304
Number of extensions: 280
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package