Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_694574                                                              18    1935
XP_005256319                                                           18    1935
XP_006721414                                                           18    1935
NP_001013433                                                           17    2528
NP_060785                                                              17    2528
NP_361014                                                              17    2528
NP_001307                                                              17    2528
NP_061182                                                              17    3301
NP_001123509                                                           17    3301
XP_005247181                                                           17    4312
NP_039227                                                              17    4312
NP_039228                                                              17    4312
NP_001004466                                                           17    4312
NP_001004465                                                           17    4312
NP_001862                                                              17    4312
NP_000005                                                              16    5631
XP_006726604                                                           16    5631
XP_006726603                                                           16    5631
XP_006725215                                                           16    5631
XP_006719240                                                           16    5631
XP_006719237                                                           16    5631
XP_006719119                                                           16    5631
NP_653252                                                              16    7355
NP_001093900                                                           16    7355
NP_001406                                                              16    7355
XP_005251225                                                           16    7355
XP_006716483                                                           16    7355
XP_005251224                                                           16    7355
XP_006714348                                                           16    7355
XP_006714347                                                           16    7355
NP_001093896                                                           16    7355
NP_001093898                                                           16    7355
NP_066982                                                              16    7355
NP_001093897                                                           16    7355
NP_001093899                                                           16    7355
NP_001261                                                              15    9605
NP_002855                                                              15    9605
NP_003787                                                              15    9605
NP_001239570                                                           15    9605
XP_005259420                                                           15    9605
XP_005259419                                                           15    9605
XP_005271924                                                           15    9605
XP_005271923                                                           15    9605
>NP_694574
          Length = 896

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELKYNILVS 9
           E++YNILV+
Sbjct: 344 EMEYNILVN 352
>XP_005256319
          Length = 678

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELKYNILVS 9
           E++YNILV+
Sbjct: 344 EMEYNILVN 352
>XP_006721414
          Length = 810

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELKYNILVS 9
           E++YNILV+
Sbjct: 258 EMEYNILVN 266
>NP_001013433
          Length = 589

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELKYNILVS 9
           ELK NILVS
Sbjct: 470 ELKDNILVS 478
>NP_060785
          Length = 627

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELKYNILVS 9
           ELK NILVS
Sbjct: 508 ELKDNILVS 516
>NP_361014
          Length = 707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ELKYNILVS 9
           ELK NILVS
Sbjct: 588 ELKDNILVS 596
>NP_001307
          Length = 971

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELKYNILVS 9
           E+KY++LVS
Sbjct: 307 EVKYDLLVS 315
>NP_061182
          Length = 334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELKYNILVS 9
           +L YN+LVS
Sbjct: 245 DLAYNLLVS 253
>NP_001123509
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ELKYNILVS 9
           +L YN+LVS
Sbjct: 237 DLAYNLLVS 245
>XP_005247181
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ELKYNILVS 9
          EL+Y +L+S
Sbjct: 87 ELQYKVLIS 95
>NP_039227
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           L+YN+L+S
Sbjct: 130 LRYNVLMS 137
>NP_039228
          Length = 318

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           L+YN+L+S
Sbjct: 130 LRYNVLMS 137
>NP_001004466
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           L+YN+L+S
Sbjct: 130 LRYNVLMS 137
>NP_001004465
          Length = 316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           L+YN+L+S
Sbjct: 131 LRYNVLMS 138
>NP_001862
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ELKYNILVS 9
          EL+Y +L+S
Sbjct: 87 ELQYKVLIS 95
>NP_000005
          Length = 1474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LKYNIL 7
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>XP_006726604
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LKYNILV 8
           LKYN+L+
Sbjct: 107 LKYNVLL 113
>XP_006726603
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LKYNILV 8
            LKYN+L+
Sbjct: 1125 LKYNVLL 1131
>XP_006725215
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LKYNILV 8
            LKYN+L+
Sbjct: 1125 LKYNVLL 1131
>XP_006719240
          Length = 113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LKYNILV 8
          LKYN+L+
Sbjct: 21 LKYNVLL 27
>XP_006719237
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LKYNILV 8
            LKYN+L+
Sbjct: 1124 LKYNVLL 1130
>XP_006719119
          Length = 1512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LKYNIL 7
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>NP_653252
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELKYNILVS 9
           E +YN LVS
Sbjct: 688 EFRYNDLVS 696
>NP_001093900
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 459 EIKYNSMV 466
>NP_001406
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           +LKYNI V
Sbjct: 227 QLKYNIEV 234
>XP_005251225
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ELKYNILVS 9
          E +YN LVS
Sbjct: 73 EFRYNDLVS 81
>XP_006716483
          Length = 1367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELKYNILVS 9
           E +YN LVS
Sbjct: 592 EFRYNDLVS 600
>XP_005251224
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ELKYNILVS 9
           E +YN LVS
Sbjct: 664 EFRYNDLVS 672
>XP_006714348
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 421 EIKYNSMV 428
>XP_006714347
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 470 EIKYNSMV 477
>NP_001093896
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 551 EIKYNSMV 558
>NP_001093898
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 502 EIKYNSMV 509
>NP_066982
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 550 EIKYNSMV 557
>NP_001093897
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 550 EIKYNSMV 557
>NP_001093899
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ELKYNILV 8
           E+KYN +V
Sbjct: 501 EIKYNSMV 508
>NP_001261
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           LK+NIL++
Sbjct: 584 LKFNILLT 591
>NP_002855
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LKYNIL 7
            +KYNIL
Sbjct: 1334 MKYNIL 1339
>NP_003787
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ELKYNILV 8
          +L YNI+V
Sbjct: 71 KLSYNIMV 78
>NP_001239570
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ELKYNILV 8
          +L YNI+V
Sbjct: 53 KLSYNIMV 60
>XP_005259420
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ELKYNILV 8
          +L YNI+V
Sbjct: 71 KLSYNIMV 78
>XP_005259419
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ELKYNILV 8
          +L YNI+V
Sbjct: 53 KLSYNIMV 60
>XP_005271924
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           LK+NIL++
Sbjct: 584 LKFNILLT 591
>XP_005271923
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LKYNILVS 9
           LK+NIL++
Sbjct: 584 LKFNILLT 591
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.138    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 471,895
Number of extensions: 755
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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