Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001189394                                                           18    1135
NP_001189393                                                           18    1135
NP_001189395                                                           18    1135
NP_001189396                                                           18    1135
XP_005252420                                                           18    1135
XP_006717439                                                           18    1135
XP_005252419                                                           18    1135
XP_005252418                                                           18    1135
NP_008969                                                              17    2528
NP_001013859                                                           17    2528
NP_001013858                                                           17    2528
NP_003541                                                              17    2528
XP_005249935                                                           17    2528
XP_005249934                                                           17    2528
XP_006715851                                                           17    2528
XP_005249933                                                           17    2528
NP_008835                                                              17    3301
NP_001075109                                                           17    3301
NP_149020                                                              17    3301
XP_006724673                                                           17    3301
NP_056277                                                              17    4312
NP_060862                                                              16    5631
XP_005263172                                                           16    5631
NP_006615                                                              16    7355
NP_997644                                                              16    7355
NP_001189397                                                           16    7355
NP_036363                                                              16    7355
NP_001007258                                                           16    7355
NP_056950                                                              16    7355
XP_006721691                                                           16    7355
XP_005252417                                                           16    7355
XP_005252416                                                           16    7355
XP_005246055                                                           16    7355
XP_006710943                                                           16    7355
XP_006710942                                                           16    7355
XP_006710941                                                           16    7355
XP_005246054                                                           16    7355
XP_005246053                                                           16    7355
XP_006710940                                                           16    7355
XP_005246052                                                           16    7355
XP_005246051                                                           16    7355
XP_005246050                                                           16    7355
XP_005246049                                                           16    7355
NP_060719                                                              15    9605
NP_001258968                                                           15    9605
NP_001011649                                                           15    9605
NP_003591                                                              15    9605
NP_940838                                                              15    9605
NP_940837                                                              15    9605
NP_940839                                                              15    9605
NP_940835                                                              15    9605
NP_940836                                                              15    9605
NP_001257449                                                           15    9605
NP_055807                                                              15    9605
NP_000411                                                              15    9605
NP_005095                                                              15    9605
NP_001186384                                                           15    9605
NP_001106653                                                           15    9605
NP_001186385                                                           15    9605
NP_004897                                                              15    9605
NP_001257460                                                           15    9605
XP_005277045                                                           15    9605
XP_006723935                                                           15    9605
XP_005260591                                                           15    9605
XP_006723934                                                           15    9605
XP_005267488                                                           15    9605
XP_005267487                                                           15    9605
XP_006717248                                                           15    9605
XP_006717247                                                           15    9605
XP_006717246                                                           15    9605
XP_006717245                                                           15    9605
XP_006717244                                                           15    9605
XP_006717243                                                           15    9605
XP_006717242                                                           15    9605
XP_005250050                                                           15    9605
>NP_001189394
          Length = 517

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>NP_001189393
          Length = 548

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>NP_001189395
          Length = 547

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>NP_001189396
          Length = 514

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>XP_005252420
          Length = 547

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>XP_006717439
          Length = 548

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>XP_005252419
          Length = 548

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>XP_005252418
          Length = 548

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  ELALKKKNT 9
          E+++KKKNT
Sbjct: 91 EISIKKKNT 99
>NP_008969
          Length = 930

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKKKN
Sbjct: 775 LALKKKN 781
>NP_001013859
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 345 ELALKDKNS 353
>NP_001013858
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 345 ELALKDKNS 353
>NP_003541
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 345 ELALKDKNS 353
>XP_005249935
          Length = 671

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 298 ELALKDKNS 306
>XP_005249934
          Length = 671

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 298 ELALKDKNS 306
>XP_006715851
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 345 ELALKDKNS 353
>XP_005249933
          Length = 718

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           ELALK KN+
Sbjct: 345 ELALKDKNS 353
>NP_008835
          Length = 4128

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELALKKK
Sbjct: 159 ELALKKK 165
>NP_001075109
          Length = 4097

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELALKKK
Sbjct: 159 ELALKKK 165
>NP_149020
          Length = 1395

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELALKKKNT 9
           +L+LKKK+T
Sbjct: 746 QLSLKKKST 754
>XP_006724673
          Length = 1396

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ELALKKKNT 9
           +L+LKKK+T
Sbjct: 746 QLSLKKKST 754
>NP_056277
          Length = 719

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   ELALKKKN 8
           E+ALKKK+
Sbjct: 475 EIALKKKD 482
>NP_060862
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LKKKNT 9
           LKKKNT
Sbjct: 845 LKKKNT 850
>XP_005263172
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LKKKNT 9
           LKKKNT
Sbjct: 845 LKKKNT 850
>NP_006615
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALKKKNT 9
           ++KKKNT
Sbjct: 147 SIKKKNT 153
>NP_997644
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALKKKNT 9
           ++KKKNT
Sbjct: 147 SIKKKNT 153
>NP_001189397
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALKKKNT 9
           ++KKKNT
Sbjct: 147 SIKKKNT 153
>NP_036363
          Length = 1718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1421 ALKKKN 1426
>NP_001007258
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>NP_056950
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1421 ALKKKN 1426
>XP_006721691
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKK+N
Sbjct: 344 LALKKEN 350
>XP_005252417
          Length = 601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALKKKNT 9
           ++KKKNT
Sbjct: 147 SIKKKNT 153
>XP_005252416
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALKKKNT 9
           ++KKKNT
Sbjct: 147 SIKKKNT 153
>XP_005246055
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>XP_006710943
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>XP_006710942
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>XP_006710941
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>XP_005246054
          Length = 1517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1220 ALKKKN 1225
>XP_005246053
          Length = 1644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1347 ALKKKN 1352
>XP_006710940
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1421 ALKKKN 1426
>XP_005246052
          Length = 1692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1431 ALKKKN 1436
>XP_005246051
          Length = 1717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1420 ALKKKN 1425
>XP_005246050
          Length = 1718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1421 ALKKKN 1426
>XP_005246049
          Length = 1728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    ALKKKN 8
            ALKKKN
Sbjct: 1431 ALKKKN 1436
>NP_060719
          Length = 1893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>NP_001258968
          Length = 1663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>NP_001011649
          Length = 1814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>NP_003591
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_940838
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_940837
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_940839
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_940835
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_940836
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>NP_001257449
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKKK+
Sbjct: 596 LALKKKS 602
>NP_055807
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKKK+
Sbjct: 596 LALKKKS 602
>NP_000411
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ELALKKKN 8
           ELA K KN
Sbjct: 120 ELATKNKN 127
>NP_005095
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 727 ELALEKK 733
>NP_001186384
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 762 ELALEKK 768
>NP_001106653
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 727 ELALEKK 733
>NP_001186385
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 680 ELALEKK 686
>NP_004897
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 186 ELALQKK 192
>NP_001257460
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ELALKKK 7
           ELAL+KK
Sbjct: 186 ELALQKK 192
>XP_005277045
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ELALKKKN 8
           ELA K KN
Sbjct: 132 ELATKNKN 139
>XP_006723935
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>XP_005260591
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 113 ELASKQKN 120
>XP_006723934
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ELALKKKN 8
           ELA K+KN
Sbjct: 129 ELASKQKN 136
>XP_005267488
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKKK+
Sbjct: 596 LALKKKS 602
>XP_005267487
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LALKKKN 8
           LALKKK+
Sbjct: 596 LALKKKS 602
>XP_006717248
          Length = 1664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>XP_006717247
          Length = 1670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>XP_006717246
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>XP_006717245
          Length = 1861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>XP_006717244
          Length = 1867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 305 EIATEKKNS 313
>XP_006717243
          Length = 1889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 295 EIATEKKNS 303
>XP_006717242
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ELALKKKNT 9
           E+A +KKN+
Sbjct: 304 EIATEKKNS 312
>XP_005250050
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   ELALKKKN 8
           ELA K KN
Sbjct: 132 ELATKNKN 139
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.116    0.270 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 524,920
Number of extensions: 941
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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