Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     299
NP_001276866                                                           18    1135
NP_004439                                                              18    1135
NP_001276865                                                           18    1135
NP_001005862                                                           18    1135
XP_005257197                                                           18    1135
XP_006721828                                                           18    1135
NP_001036064                                                           18    1482
NP_005226                                                              18    1482
XP_005246434                                                           18    1482
XP_005246433                                                           18    1482
XP_005246432                                                           18    1482
XP_006712427                                                           18    1482
NP_689916                                                              17    3301
XP_006715953                                                           17    3301
XP_006715952                                                           17    3301
XP_005250250                                                           17    3301
XP_006715951                                                           17    3301
XP_005250248                                                           17    3301
NP_002289                                                              17    4312
XP_005266431                                                           17    4312
NP_689742                                                              16    5631
NP_001028217                                                           16    5631
NP_001253979                                                           16    5631
NP_001253980                                                           16    5631
NP_490595                                                              16    5631
XP_005263889                                                           16    5631
XP_006712890                                                           16    5631
XP_005263888                                                           16    5631
XP_005263887                                                           16    5631
XP_006712406                                                           16    5631
NP_001232                                                              16    5631
NP_937784                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_000405                                                              16    7355
NP_001186221                                                           16    7355
NP_001186220                                                           16    7355
NP_001788                                                              16    7355
XP_005255824                                                           16    7355
XP_005255823                                                           16    7355
XP_005255821                                                           16    7355
XP_005255820                                                           16    7355
XP_005255819                                                           16    7355
XP_005255818                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_631917                                                              16    7355
NP_001254479                                                           16    7355
NP_996879                                                              15    9605
NP_036325                                                              15    9605
NP_036590                                                              15    9605
NP_008957                                                              15    9605
XP_006725363                                                           15    9605
XP_005257034                                                           15    9605
XP_006710494                                                           15    9605
XP_006710492                                                           15    9605
XP_006710491                                                           15    9605
XP_006710490                                                           15    9605
XP_006710489                                                           15    9605
>NP_005219
          Length = 1210

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EKVKIPIAI 9
           EKVKIP+AI
Sbjct: 736 EKVKIPVAI 744
>NP_001276866
          Length = 1055

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 744 ENVKIPVAI 752
>NP_004439
          Length = 1255

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 744 ENVKIPVAI 752
>NP_001276865
          Length = 1240

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 729 ENVKIPVAI 737
>NP_001005862
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 714 ENVKIPVAI 722
>XP_005257197
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 714 ENVKIPVAI 722
>XP_006721828
          Length = 1336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 825 ENVKIPVAI 833
>NP_001036064
          Length = 1292

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 742 ETVKIPVAI 750
>NP_005226
          Length = 1308

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 742 ETVKIPVAI 750
>XP_005246434
          Length = 1282

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 732 ETVKIPVAI 740
>XP_005246433
          Length = 1298

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 732 ETVKIPVAI 740
>XP_005246432
          Length = 1307

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 757 ETVKIPVAI 765
>XP_006712427
          Length = 1323

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E VKIP+AI
Sbjct: 757 ETVKIPVAI 765
>NP_689916
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>XP_006715953
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>XP_006715952
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>XP_005250250
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>XP_006715951
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>XP_005250248
          Length = 1584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EKVKIPI 7
            EK+KIP+
Sbjct: 1542 EKIKIPV 1548
>NP_002289
          Length = 627

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EKVKIPI 7
           EK+K+P+
Sbjct: 431 EKIKVPV 437
>XP_005266431
          Length = 627

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   EKVKIPI 7
           EK+K+P+
Sbjct: 431 EKIKVPV 437
>NP_689742
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E+V+IP+ I
Sbjct: 475 ERVQIPVGI 483
>NP_001028217
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E+V+IP+ I
Sbjct: 475 ERVQIPVGI 483
>NP_001253979
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E+V+IP+ I
Sbjct: 475 ERVQIPVGI 483
>NP_001253980
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E+V+IP+ I
Sbjct: 447 ERVQIPVGI 455
>NP_490595
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 483 KMKIPIA 489
>XP_005263889
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 308 KMKIPIA 314
>XP_006712890
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 339 KMKIPIA 345
>XP_005263888
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 339 KMKIPIA 345
>XP_005263887
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 462 KMKIPIA 468
>XP_006712406
          Length = 785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           E+V+IP+ I
Sbjct: 475 ERVQIPVGI 483
>NP_001232
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KVKIPIA 8
           K+KIPIA
Sbjct: 483 KMKIPIA 489
>NP_937784
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKIPIAI 9
           VKIP+A+
Sbjct: 760 VKIPVAL 766
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     EKVKIPIA 8
             EK+ +P+A
Sbjct: 10282 EKIPVPVA 10289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1     EKVKIPIAI 9
             EKV +P+ +
Sbjct: 10365 EKVAVPVPV 10373
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    EKVKIPIA 8
            EK+ +P+A
Sbjct: 9355 EKIPVPVA 9362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    EKVKIPIAI 9
            EKV +P+ +
Sbjct: 9438 EKVAVPVPV 9446
>NP_000405
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           +KVK+ +AI
Sbjct: 476 DKVKVAVAI 484
>NP_001186221
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           +KVK+ +AI
Sbjct: 458 DKVKVAVAI 466
>NP_001186220
          Length = 761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           +KVK+ +AI
Sbjct: 501 DKVKVAVAI 509
>NP_001788
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255824
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255823
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255821
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255820
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255819
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_005255818
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EKVKIPIAI 9
           ++ K+P+AI
Sbjct: 468 QEAKVPVAI 476
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     EKVKIPIA 8
             EK+ +P+A
Sbjct: 10283 EKIPVPVA 10290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1     EKVKIPIAI 9
             EKV +P+ +
Sbjct: 10366 EKVAVPVPV 10374
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     EKVKIPIA 8
             EK+ +P+A
Sbjct: 10283 EKIPVPVA 10290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1     EKVKIPIAI 9
             EKV +P+ +
Sbjct: 10366 EKVAVPVPV 10374
>NP_631917
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EKVKIPI 7
           E+VKIP+
Sbjct: 233 ERVKIPL 239
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1     EKVKIPIA 8
             EK+ +P+A
Sbjct: 10599 EKIPVPVA 10606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1     EKVKIPIAI 9
             EKV +P+ +
Sbjct: 10682 EKVAVPVPV 10690
>NP_996879
          Length = 2223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EKVKIP 6
            EKVK+P
Sbjct: 2027 EKVKLP 2032
>NP_036325
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EKVKIPI 7
           EK+ IPI
Sbjct: 108 EKINIPI 114
>NP_036590
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EKVKIPIAI 9
          E+VK+ IA+
Sbjct: 24 EQVKVQIAV 32
>NP_008957
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EKVKIPIA 8
          E VK+P+A
Sbjct: 72 EYVKVPLA 79
>XP_006725363
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EKVKIPIA 8
          E VK+P+A
Sbjct: 72 EYVKVPLA 79
>XP_005257034
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EKVKIPIA 8
          E VK+P+A
Sbjct: 72 EYVKVPLA 79
>XP_006710494
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EKVKIP 6
           EKVK+P
Sbjct: 956 EKVKLP 961
>XP_006710492
          Length = 1351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EKVKIP 6
            EKVK+P
Sbjct: 1155 EKVKLP 1160
>XP_006710491
          Length = 1496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EKVKIP 6
            EKVK+P
Sbjct: 1300 EKVKLP 1305
>XP_006710490
          Length = 2158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EKVKIP 6
            EKVK+P
Sbjct: 1962 EKVKLP 1967
>XP_006710489
          Length = 2185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EKVKIP 6
            EKVK+P
Sbjct: 1989 EKVKLP 1994
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.143    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 556,304
Number of extensions: 824
Number of successful extensions: 65
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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