Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     390
NP_066124                                                              20     390
XP_006717999                                                           20     390
NP_078925                                                              17    2528
NP_001177987                                                           16    7355
NP_001177988                                                           16    7355
NP_005011                                                              16    7355
NP_001177986                                                           16    7355
NP_001177985                                                           16    7355
NP_443161                                                              16    7355
NP_001104740                                                           16    7355
NP_891992                                                              16    7355
NP_054872                                                              16    7355
NP_006368                                                              16    7355
NP_001747                                                              16    7355
NP_001073890                                                           16    7355
XP_006722755                                                           16    7355
XP_005255329                                                           16    7355
XP_006720940                                                           16    7355
XP_005255327                                                           16    7355
XP_006716779                                                           16    7355
XP_005249826                                                           16    7355
XP_005249825                                                           16    7355
XP_006710380                                                           16    7355
XP_005245788                                                           16    7355
XP_006710379                                                           16    7355
XP_006710378                                                           16    7355
NP_002205                                                              15    9605
NP_005132                                                              15    9605
NP_001171670                                                           15    9605
NP_000915                                                              15    9605
NP_001245241                                                           15    9605
NP_000889                                                              15    9605
NP_006130                                                              15    9605
NP_005010                                                              15    9605
NP_001159447                                                           15    9605
NP_001003683                                                           15    9605
NP_001245242                                                           15    9605
NP_919301                                                              15    9605
NP_001275698                                                           15    9605
XP_005272665                                                           15    9605
XP_005272664                                                           15    9605
XP_005271739                                                           15    9605
XP_005249809                                                           15    9605
XP_005249808                                                           15    9605
XP_006712642                                                           15    9605
XP_005246693                                                           15    9605
XP_006712641                                                           15    9605
XP_006712640                                                           15    9605
XP_006712639                                                           15    9605
XP_006712638                                                           15    9605
XP_006712637                                                           15    9605
XP_005246692                                                           15    9605
NP_003469                                                              15    9605
>NP_065681
          Length = 1072

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLYVDQ A
Sbjct: 38 EKLYVDQAA 46
>NP_066124
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLYVDQ A
Sbjct: 38 EKLYVDQAA 46
>XP_006717999
          Length = 1207

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EKLYVDQTA 9
           EKLYVDQ A
Sbjct: 131 EKLYVDQAA 139
>NP_078925
          Length = 593

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLYVDQT 8
           +LYVDQT
Sbjct: 432 RLYVDQT 438
>NP_001177987
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   EKLYVDQT 8
           E +Y+D+T
Sbjct: 133 ESVYIDET 140
>NP_001177988
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 73 ESVYIDET 80
>NP_005011
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 73 ESVYIDET 80
>NP_001177986
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 73 ESVYIDET 80
>NP_001177985
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 73 ESVYIDET 80
>NP_443161
          Length = 1412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EKLYVDQT 8
            EKLY+D +
Sbjct: 1243 EKLYLDMS 1250
>NP_001104740
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EKLYVD 6
           EK+YVD
Sbjct: 211 EKMYVD 216
>NP_891992
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EKLYVD 6
           EK+YVD
Sbjct: 172 EKMYVD 177
>NP_054872
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLY+++ A
Sbjct: 89 EKLYINRIA 97
>NP_006368
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLYVDQTA 9
           K+Y D+TA
Sbjct: 775 KVYFDETA 782
>NP_001747
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EKLYVDQT 8
           E  YVD+T
Sbjct: 219 ENFYVDET 226
>NP_001073890
          Length = 1703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLYVDQTA 9
           K+Y D+TA
Sbjct: 851 KVYYDETA 858
>XP_006722755
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLYVDQTA 9
           K+Y D+TA
Sbjct: 851 KVYYDETA 858
>XP_005255329
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLY+++ A
Sbjct: 89 EKLYINRIA 97
>XP_006720940
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLY+++ A
Sbjct: 89 EKLYINRIA 97
>XP_005255327
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  EKLYVDQTA 9
          EKLY+++ A
Sbjct: 89 EKLYINRIA 97
>XP_006716779
          Length = 2399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KLYVDQTA 9
            K+Y D+TA
Sbjct: 1583 KVYFDETA 1590
>XP_005249826
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 35 ESVYIDET 42
>XP_005249825
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   EKLYVDQT 8
           E +Y+D+T
Sbjct: 133 ESVYIDET 140
>XP_006710380
          Length = 1398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EKLYVDQT 8
            EKLY+D +
Sbjct: 1229 EKLYLDMS 1236
>XP_005245788
          Length = 1434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EKLYVDQT 8
            EKLY+D +
Sbjct: 1265 EKLYLDMS 1272
>XP_006710379
          Length = 1452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EKLYVDQT 8
            EKLY+D +
Sbjct: 1265 EKLYLDMS 1272
>XP_006710378
          Length = 1478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    EKLYVDQT 8
            EKLY+D +
Sbjct: 1264 EKLYLDMS 1271
>NP_002205
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YVDQTA 9
           YVDQT+
Sbjct: 669 YVDQTS 674
>NP_005132
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLYVDQT 8
           +LY+D+T
Sbjct: 180 QLYIDET 186
>NP_001171670
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLYVDQT 8
           +LY+D+T
Sbjct: 121 QLYIDET 127
>NP_000915
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 68 EAVYIDET 75
>NP_001245241
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 68 EAVYIDET 75
>NP_000889
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LYVDQT 8
           +Y+DQT
Sbjct: 236 IYIDQT 241
>NP_006130
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EKLYVDQT 8
           + LYV+QT
Sbjct: 100 QNLYVNQT 107
>NP_005010
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>NP_001159447
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 48 EAVYIDET 55
>NP_001003683
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>NP_001245242
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 48 EAVYIDET 55
>NP_919301
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EKLYVDQ 7
           E+LYVD+
Sbjct: 511 EELYVDR 517
>NP_001275698
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 27 EAVYIDET 34
>XP_005272665
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LYVDQT 8
           +Y+DQT
Sbjct: 220 IYIDQT 225
>XP_005272664
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LYVDQT 8
           +Y+DQT
Sbjct: 220 IYIDQT 225
>XP_005271739
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EKLYVDQT 8
           EK Y+D T
Sbjct: 144 EKAYLDST 151
>XP_005249809
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YVDQTA 9
           YVDQT+
Sbjct: 534 YVDQTS 539
>XP_005249808
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YVDQTA 9
           YVDQT+
Sbjct: 534 YVDQTS 539
>XP_006712642
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_005246693
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 48 EAVYIDET 55
>XP_006712641
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_006712640
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_006712639
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_006712638
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_006712637
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>XP_005246692
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  EKLYVDQT 8
          E +Y+D+T
Sbjct: 64 EAVYIDET 71
>NP_003469
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EKLYVDQT 8
           EK Y+D T
Sbjct: 203 EKAYLDST 210
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.124    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,795
Number of extensions: 979
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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