Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_689911                                                              17    4312
NP_001098664                                                           17    4312
NP_001098665                                                           17    4312
NP_001098663                                                           17    4312
XP_005268276                                                           17    4312
NP_004265                                                              17    4312
NP_005742                                                              16    5631
NP_671714                                                              16    5631
NP_005115                                                              16    5631
NP_001265138                                                           16    5631
NP_001265139                                                           16    5631
NP_001985                                                              16    5631
NP_001098998                                                           16    5631
NP_945346                                                              16    5631
NP_071910                                                              16    5631
XP_005269148                                                           16    5631
XP_005269149                                                           16    5631
XP_005269147                                                           16    5631
XP_005269146                                                           16    5631
XP_005269144                                                           16    5631
XP_006719624                                                           16    5631
XP_005269143                                                           16    5631
XP_006715890                                                           16    5631
XP_005250160                                                           16    5631
XP_005250159                                                           16    5631
XP_006715354                                                           16    5631
XP_005249564                                                           16    5631
XP_006715353                                                           16    5631
XP_005245011                                                           16    5631
XP_005245010                                                           16    5631
NP_060580                                                              16    7355
NP_001136037                                                           16    7355
NP_001129512                                                           16    7355
NP_079087                                                              16    7355
XP_005256100                                                           16    7355
XP_005256099                                                           16    7355
XP_006719430                                                           16    7355
XP_006719429                                                           16    7355
XP_006719428                                                           16    7355
XP_005253933                                                           16    7355
XP_005274356                                                           16    7355
XP_005274355                                                           16    7355
XP_006718754                                                           16    7355
XP_006718753                                                           16    7355
NP_001084                                                              16    7355
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_001121782                                                           15    9605
NP_004675                                                              15    9605
NP_620416                                                              15    9605
NP_001188394                                                           15    9605
NP_005091                                                              15    9605
NP_653080                                                              15    9605
NP_620552                                                              15    9605
NP_001247415                                                           15    9605
NP_932355                                                              15    9605
NP_003436                                                              15    9605
NP_001018126                                                           15    9605
NP_001247417                                                           15    9605
NP_653244                                                              15    9605
NP_001247416                                                           15    9605
XP_005259272                                                           15    9605
XP_005266833                                                           15    9605
XP_005266831                                                           15    9605
XP_005266830                                                           15    9605
XP_005267292                                                           15    9605
XP_005267291                                                           15    9605
XP_005267290                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1959 EIYADKKSM 1967
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EIYADEKSM 9
           EIYAD+KSM
Sbjct: 611 EIYADKKSM 619
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1611 EIYADKKSM 1619
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1953 EIYADKKSM 1961
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1959 EIYADKKSM 1967
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1959 EIYADKKSM 1967
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    EIYADEKSM 9
            EIYAD+KSM
Sbjct: 1959 EIYADKKSM 1967
>NP_689911
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           E++ADE S+
Sbjct: 252 EVFADESSV 260
>NP_001098664
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           E++ADE S+
Sbjct: 252 EVFADESSV 260
>NP_001098665
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           E++ADE S+
Sbjct: 252 EVFADESSV 260
>NP_001098663
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           E++ADE S+
Sbjct: 252 EVFADESSV 260
>XP_005268276
          Length = 2320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   YADEKS 8
           YADEKS
Sbjct: 736 YADEKS 741
>NP_004265
          Length = 2319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   YADEKS 8
           YADEKS
Sbjct: 736 YADEKS 741
>NP_005742
          Length = 3907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            YADEK++
Sbjct: 1927 YADEKTL 1933
>NP_671714
          Length = 3899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            YADEK++
Sbjct: 1927 YADEKTL 1933
>NP_005115
          Length = 1475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_001265138
          Length = 1506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_001265139
          Length = 1433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_001985
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          E+YA+EK
Sbjct: 17 ELYAEEK 23
>NP_001098998
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           +IY DEK++
Sbjct: 329 DIYQDEKTI 337
>NP_945346
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EIYADEKSM 9
           +IY DEK++
Sbjct: 329 DIYQDEKTI 337
>NP_071910
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           E+Y+DE+S
Sbjct: 102 EMYSDEES 109
>XP_005269148
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 55 EMYSDEES 62
>XP_005269149
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 55 EMYSDEES 62
>XP_005269147
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 55 EMYSDEES 62
>XP_005269146
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 55 EMYSDEES 62
>XP_005269144
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 61 EMYSDEES 68
>XP_006719624
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 80 EMYSDEES 87
>XP_005269143
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EIYADEKS 8
          E+Y+DE+S
Sbjct: 80 EMYSDEES 87
>XP_006715890
          Length = 3860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            YADEK++
Sbjct: 1880 YADEKTL 1886
>XP_005250160
          Length = 3939

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            YADEK++
Sbjct: 1959 YADEKTL 1965
>XP_005250159
          Length = 3952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            YADEK++
Sbjct: 1959 YADEKTL 1965
>XP_006715354
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>XP_005249564
          Length = 1457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>XP_006715353
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IYADEKS 8
          +YADE+S
Sbjct: 87 VYADEES 93
>XP_005245011
          Length = 629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          E+YA+EK
Sbjct: 17 ELYAEEK 23
>XP_005245010
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          E+YA+EK
Sbjct: 17 ELYAEEK 23
>NP_060580
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EIYADEKSM 9
          E Y DEKS+
Sbjct: 43 EKYPDEKSV 51
>NP_001136037
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 9  DIYADEE 15
>NP_001129512
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 9  DIYADEE 15
>NP_079087
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 52 DIYADEE 58
>XP_005256100
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EIYADEKSM 9
          E Y DEKS+
Sbjct: 43 EKYPDEKSV 51
>XP_005256099
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EIYADEKSM 9
          E Y DEKS+
Sbjct: 43 EKYPDEKSV 51
>XP_006719430
          Length = 2256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    EIYADEKS 8
            E+YAD++S
Sbjct: 2015 EMYADKES 2022
>XP_006719429
          Length = 2395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    EIYADEKS 8
            E+YAD++S
Sbjct: 2154 EMYADKES 2161
>XP_006719428
          Length = 2458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    EIYADEKS 8
            E+YAD++S
Sbjct: 2217 EMYADKES 2224
>XP_005253933
          Length = 2458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    EIYADEKS 8
            E+YAD++S
Sbjct: 2217 EMYADKES 2224
>XP_005274356
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 9  DIYADEE 15
>XP_005274355
          Length = 505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 52 DIYADEE 58
>XP_006718754
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 52 DIYADEE 58
>XP_006718753
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  EIYADEK 7
          +IYADE+
Sbjct: 52 DIYADEE 58
>NP_001084
          Length = 2458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    EIYADEKS 8
            E+YAD++S
Sbjct: 2217 EMYADKES 2224
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            +ADEKS+
Sbjct: 1115 HADEKSL 1121
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YADEKSM 9
            +ADEKS+
Sbjct: 1115 HADEKSL 1121
>NP_001121782
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EIYADEKSM 9
           +IY DEK +
Sbjct: 559 KIYLDEKRL 567
>NP_004675
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EIYADEKSM 9
           +IY DEK +
Sbjct: 559 KIYLDEKRL 567
>NP_620416
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 81 ELYFDEK 87
>NP_001188394
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 81 ELYFDEK 87
>NP_005091
          Length = 1782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YADEKS 8
            YADEK+
Sbjct: 1270 YADEKT 1275
>NP_653080
          Length = 1684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YADEKS 8
            YADEK+
Sbjct: 1172 YADEKT 1177
>NP_620552
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 80 ELYFDEK 86
>NP_001247415
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 168 QLYSEEKS 175
>NP_932355
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 168 QLYSEEKS 175
>NP_003436
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 168 QLYSEEKS 175
>NP_001018126
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EIYADEKS 8
           E+Y+DE S
Sbjct: 308 ELYSDELS 315
>NP_001247417
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 179 QLYSEEKS 186
>NP_653244
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   EIYADEKSM 9
           +IYAD++++
Sbjct: 122 DIYADDETV 130
>NP_001247416
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 168 QLYSEEKS 175
>XP_005259272
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EIYADEKS 8
           ++Y++EKS
Sbjct: 168 QLYSEEKS 175
>XP_005266833
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 81 ELYFDEK 87
>XP_005266831
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 81 ELYFDEK 87
>XP_005266830
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EIYADEK 7
          E+Y DEK
Sbjct: 81 ELYFDEK 87
>XP_005267292
          Length = 1677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YADEKS 8
            YADEK+
Sbjct: 1165 YADEKT 1170
>XP_005267291
          Length = 1684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YADEKS 8
            YADEK+
Sbjct: 1172 YADEKT 1177
>XP_005267290
          Length = 1782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    YADEKS 8
            YADEK+
Sbjct: 1270 YADEKT 1275
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.120    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 570,501
Number of extensions: 1179
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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