Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001262                                                              20     390
NP_001261                                                              20     509
XP_005271924                                                           20     509
XP_005271923                                                           20     509
NP_058633                                                              18    1482
XP_006724562                                                           18    1482
XP_005274609                                                           18    1482
NP_001120                                                              16    5631
NP_071401                                                              16    5631
NP_001273561                                                           16    5631
NP_001273560                                                           16    5631
XP_006719923                                                           16    5631
XP_006719922                                                           16    5631
XP_005266558                                                           16    5631
XP_006719921                                                           16    5631
XP_005266556                                                           16    5631
XP_005266555                                                           16    5631
XP_006719920                                                           16    5631
XP_005266554                                                           16    5631
XP_005266553                                                           16    5631
XP_006719919                                                           16    5631
XP_005266551                                                           16    5631
XP_005266550                                                           16    5631
XP_005266549                                                           16    5631
XP_006719918                                                           16    5631
XP_005266548                                                           16    5631
NP_008986                                                              15    9605
NP_001182068                                                           15    9605
NP_073600                                                              15    9605
NP_001128567                                                           15    9605
NP_001159751                                                           15    9605
NP_055686                                                              15    9605
NP_001120932                                                           15    9605
NP_056201                                                              15    9605
NP_002903                                                              15    9605
NP_001273361                                                           15    9605
NP_001273360                                                           15    9605
NP_001231902                                                           15    9605
NP_001231901                                                           15    9605
NP_775267                                                              15    9605
NP_775268                                                              15    9605
NP_005727                                                              15    9605
NP_775266                                                              15    9605
NP_004094                                                              15    9605
NP_001271270                                                           15    9605
NP_078613                                                              15    9605
NP_001019800                                                           15    9605
NP_001019799                                                           15    9605
NP_001847                                                              15    9605
NP_003899                                                              15    9605
NP_003864                                                              15    9605
NP_009201                                                              15    9605
XP_005260662                                                           15    9605
XP_006721237                                                           15    9605
XP_006717660                                                           15    9605
XP_006717589                                                           15    9605
XP_006717588                                                           15    9605
XP_006717587                                                           15    9605
XP_006717586                                                           15    9605
XP_006717585                                                           15    9605
XP_006717584                                                           15    9605
XP_005273505                                                           15    9605
XP_005273504                                                           15    9605
XP_005250693                                                           15    9605
XP_005267148                                                           15    9605
XP_005267147                                                           15    9605
XP_006715607                                                           15    9605
XP_006715606                                                           15    9605
XP_005270538                                                           15    9605
NP_004176                                                              15    9605
>NP_001262
          Length = 1828

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            EIRRFIK Y
Sbjct: 1135 EIRRFIKAY 1143
>NP_001261
          Length = 1710

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            EIRRFIK Y
Sbjct: 1130 EIRRFIKSY 1138
>XP_005271924
          Length = 1710

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            EIRRFIK Y
Sbjct: 1130 EIRRFIKSY 1138
>XP_005271923
          Length = 1798

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            EIRRFIK Y
Sbjct: 1130 EIRRFIKSY 1138
>NP_058633
          Length = 1462

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            +IRRFIK Y
Sbjct: 1333 DIRRFIKKY 1341
>XP_006724562
          Length = 1326

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            +IRRFIK Y
Sbjct: 1197 DIRRFIKKY 1205
>XP_005274609
          Length = 1468

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EIRRFIKIY 9
            +IRRFIK Y
Sbjct: 1339 DIRRFIKKY 1347
>NP_001120
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRRFIKIY 9
           + RFI+IY
Sbjct: 516 VARFIRIY 523
>NP_071401
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 597 RFIKVY 602
>NP_001273561
          Length = 983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 597 RFIKVY 602
>NP_001273560
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 602 RFIKVY 607
>XP_006719923
          Length = 734

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 324 RFIKVY 329
>XP_006719922
          Length = 942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_005266558
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 597 RFIKVY 602
>XP_006719921
          Length = 983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 597 RFIKVY 602
>XP_005266556
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_005266555
          Length = 998

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_006719920
          Length = 999

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_005266554
          Length = 1000

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_005266553
          Length = 1007

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 597 RFIKVY 602
>XP_006719919
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 602 RFIKVY 607
>XP_005266551
          Length = 1012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 602 RFIKVY 607
>XP_005266550
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 607 RFIKVY 612
>XP_005266549
          Length = 1019

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>XP_006719918
          Length = 1021

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 611 RFIKVY 616
>XP_005266548
          Length = 1022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFIK+Y
Sbjct: 612 RFIKVY 617
>NP_008986
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EIRRFIK 7
           EI++FIK
Sbjct: 968 EIKKFIK 974
>NP_001182068
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EIRRFIKIY 9
           ++ RF KI+
Sbjct: 218 QVERFFKIF 226
>NP_073600
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RRFIKIY 9
            +RFI IY
Sbjct: 1002 KRFISIY 1008
>NP_001128567
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RRFIKIY 9
            +RFI IY
Sbjct: 1002 KRFISIY 1008
>NP_001159751
          Length = 1201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RF+K+Y
Sbjct: 265 RFLKVY 270
>NP_055686
          Length = 1198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RF+K+Y
Sbjct: 265 RFLKVY 270
>NP_001120932
          Length = 1202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RF+K+Y
Sbjct: 265 RFLKVY 270
>NP_056201
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EIRRFIKIY 9
           ++ RF KI+
Sbjct: 218 QVERFFKIF 226
>NP_002903
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RRFIKIY 9
           R F+KIY
Sbjct: 120 RHFMKIY 126
>NP_001273361
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  RRFIKIY 9
          R F+KIY
Sbjct: 42 RHFMKIY 48
>NP_001273360
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  RRFIKIY 9
          R F+KIY
Sbjct: 42 RHFMKIY 48
>NP_001231902
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>NP_001231901
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>NP_775267
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>NP_775268
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>NP_005727
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   EIRRFIKIY 9
           ++ RF+++Y
Sbjct: 189 DVSRFLRLY 197
>NP_775266
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>NP_004094
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>NP_001271270
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRFIKI 8
           RRF+KI
Sbjct: 159 RRFVKI 164
>NP_078613
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IRRFIKI 8
           +RRF+K+
Sbjct: 229 VRRFLKL 235
>NP_001019800
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>NP_001019799
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>NP_001847
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EIRRFIK 7
            EI+RFI+
Sbjct: 1438 EIKRFIR 1444
>NP_003899
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRRFIKIY 9
           +RR+IK Y
Sbjct: 271 LRRYIKEY 278
>NP_003864
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>NP_009201
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRFIKI 8
           RRF+KI
Sbjct: 106 RRFVKI 111
>XP_005260662
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRRFIKIY 9
           +RR+IK Y
Sbjct: 252 LRRYIKEY 259
>XP_006721237
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  EIRRFIKIY 9
          ++ RF KI+
Sbjct: 76 QVERFFKIF 84
>XP_006717660
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EIRRFIK 7
           EI++FIK
Sbjct: 947 EIKKFIK 953
>XP_006717589
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_006717588
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_006717587
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_006717586
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_006717585
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_006717584
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RFIKIY 9
           RFI+IY
Sbjct: 560 RFIRIY 565
>XP_005273505
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>XP_005273504
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EIRRFIK 7
           E+RRF K
Sbjct: 182 ELRRFFK 188
>XP_005250693
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EIRRFIKIY 9
           E+R F+K Y
Sbjct: 339 EVRLFLKNY 347
>XP_005267148
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RRFIKIY 9
           R F+KIY
Sbjct: 120 RHFMKIY 126
>XP_005267147
          Length = 2689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RRFIKIY 9
           R F+KIY
Sbjct: 120 RHFMKIY 126
>XP_006715607
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  RRFIKIY 9
          R F+KIY
Sbjct: 42 RHFMKIY 48
>XP_006715606
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RRFIKIY 9
           R F+KIY
Sbjct: 120 RHFMKIY 126
>XP_005270538
          Length = 1588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    EIRRFIK 7
            EI+RFI+
Sbjct: 1422 EIKRFIR 1428
>NP_004176
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IRRFIKI 8
           +RRF+K+
Sbjct: 210 VRRFLKL 216
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.349    0.167    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 399,043
Number of extensions: 691
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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