Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              22     134
XP_005265800                                                           22     134
XP_006714103                                                           22     134
XP_006714102                                                           22     134
NP_055811                                                              18    1935
XP_005247296                                                           18    1935
XP_006713604                                                           18    1935
XP_005247295                                                           18    1935
NP_001124432                                                           18    1935
NP_002600                                                              17    2528
XP_005268521                                                           17    2528
NP_001360                                                              17    3301
NP_005227                                                              17    3301
NP_000213                                                              17    3301
NP_001087241                                                           17    3301
XP_005248319                                                           17    3301
XP_005265799                                                           17    3301
XP_005265798                                                           17    3301
XP_005265797                                                           17    3301
NP_001245370                                                           16    5631
NP_001245371                                                           16    5631
NP_001245369                                                           16    5631
NP_001107566                                                           16    5631
NP_037446                                                              16    5631
NP_055246                                                              16    5631
NP_002802                                                              16    5631
XP_006717829                                                           16    5631
XP_006717828                                                           16    5631
NP_037361                                                              16    7355
NP_851999                                                              16    7355
NP_005791                                                              16    7355
NP_863651                                                              16    7355
NP_001151                                                              16    7355
NP_863658                                                              16    7355
NP_699197                                                              16    7355
NP_001185461                                                           16    7355
NP_001185462                                                           16    7355
XP_005266271                                                           16    7355
XP_006719814                                                           16    7355
XP_005266270                                                           16    7355
XP_006716659                                                           16    7355
XP_005251053                                                           16    7355
XP_005251052                                                           16    7355
XP_006716658                                                           16    7355
XP_005251051                                                           16    7355
XP_005251050                                                           16    7355
XP_006716657                                                           16    7355
XP_006716107                                                           16    7355
XP_006716106                                                           16    7355
NP_060472                                                              16    7355
NP_061116                                                              16    7355
NP_055313                                                              15    9605
NP_065099                                                              15    9605
NP_001244210                                                           15    9605
NP_689596                                                              15    9605
NP_003265                                                              15    9605
NP_004286                                                              15    9605
NP_775764                                                              15    9605
NP_001982                                                              15    9605
XP_006724110                                                           15    9605
XP_005261226                                                           15    9605
XP_006724109                                                           15    9605
XP_005261225                                                           15    9605
XP_005257203                                                           15    9605
XP_005257202                                                           15    9605
XP_005257201                                                           15    9605
XP_006715867                                                           15    9605
XP_005249971                                                           15    9605
XP_005247423                                                           15    9605
XP_005247422                                                           15    9605
XP_005247421                                                           15    9605
>NP_006197
          Length = 1089

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EHATSEVYE 9
           +HATSEVYE
Sbjct: 919 DHATSEVYE 927
>XP_005265800
          Length = 1089

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EHATSEVYE 9
           +HATSEVYE
Sbjct: 919 DHATSEVYE 927
>XP_006714103
          Length = 1111

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EHATSEVYE 9
           +HATSEVYE
Sbjct: 941 DHATSEVYE 949
>XP_006714102
          Length = 1114

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EHATSEVYE 9
           +HATSEVYE
Sbjct: 944 DHATSEVYE 952
>NP_055811
          Length = 1655

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EHATSEVYE 9
            +HAT+ VYE
Sbjct: 1230 KHATNTVYE 1238
>XP_005247296
          Length = 1673

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EHATSEVYE 9
            +HAT+ VYE
Sbjct: 1248 KHATNTVYE 1256
>XP_006713604
          Length = 1685

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EHATSEVYE 9
            +HAT+ VYE
Sbjct: 1260 KHATNTVYE 1268
>XP_005247295
          Length = 1705

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EHATSEVYE 9
            +HAT+ VYE
Sbjct: 1280 KHATNTVYE 1288
>NP_001124432
          Length = 1693

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EHATSEVYE 9
            +HAT+ VYE
Sbjct: 1268 KHATNTVYE 1276
>NP_002600
          Length = 1106

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HATSEVYE 9
           HA+ E+YE
Sbjct: 928 HASDEIYE 935
>XP_005268521
          Length = 1042

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HATSEVYE 9
           HA+ E+YE
Sbjct: 864 HASDEIYE 871
>NP_001360
          Length = 4624

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EHATSEVYE 9
            EH T EVY+
Sbjct: 3873 EHMTYEVYK 3881
>NP_005227
          Length = 916

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   HATSEVYE 9
           HAT+E++E
Sbjct: 807 HATAELFE 814
>NP_000213
          Length = 976

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EHA +E+Y+
Sbjct: 893 EHAPAEMYD 901
>NP_001087241
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EHA +E+Y+
Sbjct: 889 EHAPAEMYD 897
>XP_005248319
          Length = 4609

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EHATSEVYE 9
            EH T EVY+
Sbjct: 3858 EHMTYEVYK 3866
>XP_005265799
          Length = 973

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EHA +E+Y+
Sbjct: 890 EHAPAEMYD 898
>XP_005265798
          Length = 976

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EHA +E+Y+
Sbjct: 893 EHAPAEMYD 901
>XP_005265797
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EHA +E+Y+
Sbjct: 894 EHAPAEMYD 902
>NP_001245370
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EHATSEVY 8
          EH+ SE+Y
Sbjct: 77 EHSDSEMY 84
>NP_001245371
          Length = 299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EHATSEVY 8
          EH+ SE+Y
Sbjct: 77 EHSDSEMY 84
>NP_001245369
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EHATSEVY 8
          EH+ SE+Y
Sbjct: 77 EHSDSEMY 84
>NP_001107566
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EHATSEVY 8
          EH+ SE+Y
Sbjct: 77 EHSDSEMY 84
>NP_037446
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EHATSEVY 8
          EH+ SE+Y
Sbjct: 77 EHSDSEMY 84
>NP_055246
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           H T EVY+
Sbjct: 248 HVTEEVYK 255
>NP_002802
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EHATSEV 7
           EH TSE+
Sbjct: 156 EHVTSEI 162
>XP_006717829
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           H T EVY+
Sbjct: 248 HVTEEVYK 255
>XP_006717828
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           H T EVY+
Sbjct: 248 HVTEEVYK 255
>NP_037361
          Length = 1237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSEVY+
Sbjct: 559 EPETSEVYQ 567
>NP_851999
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 392 EHSTNEV 398
>NP_005791
          Length = 1092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HA SEV E
Sbjct: 845 HAASEVLE 852
>NP_863651
          Length = 1248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSEVY+
Sbjct: 570 EPETSEVYQ 578
>NP_001151
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSEVY+
Sbjct: 559 EPETSEVYQ 567
>NP_863658
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSEVY+
Sbjct: 570 EPETSEVYQ 578
>NP_699197
          Length = 3571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1    EHATSEVYE 9
            EH T  ++E
Sbjct: 2216 EHTTGRIFE 2224
>NP_001185461
          Length = 874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 400 EHSTNEV 406
>NP_001185462
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 399 EHSTNEV 405
>XP_005266271
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HA SEV E
Sbjct: 664 HAASEVLE 671
>XP_006719814
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HA SEV E
Sbjct: 839 HAASEVLE 846
>XP_005266270
          Length = 1092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HA SEV E
Sbjct: 845 HAASEVLE 852
>XP_006716659
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 400 EHSTNEV 406
>XP_005251053
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 330 EHSTNEV 336
>XP_005251052
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 332 EHSTNEV 338
>XP_006716658
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 400 EHSTNEV 406
>XP_005251051
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 392 EHSTNEV 398
>XP_005251050
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 399 EHSTNEV 405
>XP_006716657
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 400 EHSTNEV 406
>XP_006716107
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSE+YE
Sbjct: 116 EPMTSELYE 124
>XP_006716106
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSE+YE
Sbjct: 116 EPMTSELYE 124
>NP_060472
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EHATSEV 7
           EH+T+EV
Sbjct: 399 EHSTNEV 405
>NP_061116
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EHATSEVYE 9
           E  TSE+YE
Sbjct: 108 EPMTSELYE 116
>NP_055313
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HA +EVY
Sbjct: 388 HARAEVY 394
>NP_065099
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EHATSE 6
           EHAT+E
Sbjct: 179 EHATNE 184
>NP_001244210
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EH++ EV++
Sbjct: 519 EHSSEEVHQ 527
>NP_689596
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EHATSEVYE 9
           EH++ EV++
Sbjct: 519 EHSSEEVHQ 527
>NP_003265
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HAT E+Y
Sbjct: 463 HATIEMY 469
>NP_004286
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EHATSE 6
           +HATSE
Sbjct: 182 QHATSE 187
>NP_775764
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   EHATSEVYE 9
           EH  S  YE
Sbjct: 118 EHGDSSAYE 126
>NP_001982
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HAT  VY+
Sbjct: 313 HATPNVYK 320
>XP_006724110
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HAT E+Y
Sbjct: 463 HATIEMY 469
>XP_005261226
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HAT E+Y
Sbjct: 174 HATIEMY 180
>XP_006724109
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HAT E+Y
Sbjct: 463 HATIEMY 469
>XP_005261225
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HAT E+Y
Sbjct: 463 HATIEMY 469
>XP_005257203
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HAT  VY+
Sbjct: 273 HATPNVYK 280
>XP_005257202
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HAT  VY+
Sbjct: 279 HATPNVYK 286
>XP_005257201
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HATSEVYE 9
           HAT  VY+
Sbjct: 319 HATPNVYK 326
>XP_006715867
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  EHATSEVY 8
          EH  S++Y
Sbjct: 89 EHTPSQIY 96
>XP_005249971
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  EHATSEVY 8
          EH  S++Y
Sbjct: 89 EHTPSQIY 96
>XP_005247423
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HA +EVY
Sbjct: 360 HARAEVY 366
>XP_005247422
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HA +EVY
Sbjct: 360 HARAEVY 366
>XP_005247421
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HATSEVY 8
           HA +EVY
Sbjct: 388 HARAEVY 394
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.109    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,654
Number of extensions: 880
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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