Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_006723199                                                           18    1135
XP_006723198                                                           18    1135
XP_006723197                                                           18    1135
XP_006723196                                                           18    1135
NP_056418                                                              18    1135
NP_001010848                                                           16    5631
NP_001159444                                                           16    5631
XP_005276355                                                           16    5631
XP_005269501                                                           16    5631
XP_005250801                                                           16    5631
XP_005276060                                                           16    5631
NP_005568                                                              16    7355
NP_001924                                                              16    7355
NP_055514                                                              16    7355
NP_510882                                                              16    7355
NP_114146                                                              16    7355
NP_001019552                                                           16    7355
NP_001019551                                                           16    7355
NP_001073890                                                           16    7355
XP_006722755                                                           16    7355
XP_005255769                                                           16    7355
XP_005255768                                                           16    7355
XP_005255767                                                           16    7355
XP_005255623                                                           16    7355
XP_006719007                                                           16    7355
XP_006716471                                                           16    7355
XP_005273714                                                           16    7355
NP_076936                                                              16    7355
NP_056078                                                              15    9605
NP_001155018                                                           15    9605
NP_001078945                                                           15    9605
NP_001275716                                                           15    9605
NP_001167587                                                           15    9605
NP_001167588                                                           15    9605
NP_001076437                                                           15    9605
NP_065904                                                              15    9605
NP_872378                                                              15    9605
NP_001028723                                                           15    9605
NP_001136336                                                           15    9605
XP_006723212                                                           15    9605
XP_006721417                                                           15    9605
XP_006721416                                                           15    9605
XP_005254315                                                           15    9605
XP_005254314                                                           15    9605
XP_006720509                                                           15    9605
XP_005254313                                                           15    9605
XP_005254312                                                           15    9605
NP_954586                                                              15    9605

>XP_006723199
          Length = 505

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  EGVAVASPR 9
          EGVAV +PR
Sbjct: 48 EGVAVTAPR 56



>XP_006723198
          Length = 587

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  EGVAVASPR 9
          EGVAV +PR
Sbjct: 48 EGVAVTAPR 56



>XP_006723197
          Length = 587

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  EGVAVASPR 9
          EGVAV +PR
Sbjct: 48 EGVAVTAPR 56



>XP_006723196
          Length = 587

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  EGVAVASPR 9
          EGVAV +PR
Sbjct: 48 EGVAVTAPR 56



>NP_056418
          Length = 531

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  EGVAVASPR 9
          EGVAV +PR
Sbjct: 48 EGVAVTAPR 56



>NP_001010848
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  EGVAVASP 8
          EG A ASP
Sbjct: 3  EGAAAASP 10



>NP_001159444
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  EGVAVASP 8
          EG A ASP
Sbjct: 3  EGAAAASP 10



>XP_005276355
          Length = 233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GVAVASP 8
          G+AVASP
Sbjct: 38 GLAVASP 44



>XP_005269501
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  EGVAVASP 8
          EG A ASP
Sbjct: 3  EGAAAASP 10



>XP_005250801
          Length = 233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GVAVASP 8
          G+AVASP
Sbjct: 38 GLAVASP 44



>XP_005276060
          Length = 233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GVAVASP 8
          G+AVASP
Sbjct: 38 GLAVASP 44



>NP_005568
          Length = 2040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 109 EGTAVAPP 116




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 223 EGTAVAPP 230




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 337 EGTAVAPP 344




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 451 EGTAVAPP 458




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 565 EGTAVAPP 572




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 679 EGTAVAPP 686




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 793 EGTAVAPP 800




 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG AVA P
Sbjct: 907 EGTAVAPP 914



>NP_001924
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VAVASPR 9
           VAVA+PR
Sbjct: 319 VAVATPR 325



>NP_055514
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EGVA A+P
Sbjct: 920 EGVAEAAP 927



>NP_510882
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EGVAVASPR 9
           +G+  ASPR
Sbjct: 125 DGIECASPR 133



>NP_114146
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          +G+  ASPR
Sbjct: 82 DGIECASPR 90



>NP_001019552
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          +G+  ASPR
Sbjct: 82 DGIECASPR 90



>NP_001019551
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          +G+  ASPR
Sbjct: 82 DGIECASPR 90



>NP_001073890
          Length = 1703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EGVAVASPR 9
           E VAVA P+
Sbjct: 362 EDVAVAEPK 370



>XP_006722755
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EGVAVASPR 9
           E VAVA P+
Sbjct: 362 EDVAVAEPK 370



>XP_005255769
          Length = 1808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EGVA A+P
Sbjct: 920 EGVAEAAP 927



>XP_005255768
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EGVA A+P
Sbjct: 920 EGVAEAAP 927



>XP_005255767
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EGVA A+P
Sbjct: 920 EGVAEAAP 927



>XP_005255623
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EGVAVASPR 9
           EG A  SPR
Sbjct: 298 EGTASVSPR 306



>XP_006719007
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          EGV + +PR
Sbjct: 6  EGVLIQTPR 14



>XP_006716471
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          +G+  ASPR
Sbjct: 82 DGIECASPR 90



>XP_005273714
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  EGVAVASPR 9
          +G+  ASPR
Sbjct: 82 DGIECASPR 90



>NP_076936
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EGVAVASPR 9
           EG A  SPR
Sbjct: 298 EGTASVSPR 306



>NP_056078
          Length = 3036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>NP_001155018
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EGVAVASPR 9
           EG A A PR
Sbjct: 195 EGAAPARPR 203



>NP_001078945
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG A+A+P
Sbjct: 286 EGAALATP 293



>NP_001275716
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG+ VA P
Sbjct: 380 EGIPVAQP 387



>NP_001167587
          Length = 3037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>NP_001167588
          Length = 2400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>NP_001076437
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG+ VA P
Sbjct: 425 EGIPVAQP 432



>NP_065904
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++ ASP
Sbjct: 499 EGLSAASP 506



>NP_872378
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EGVAVASPR 9
           EG  ++SP+
Sbjct: 231 EGTVISSPK 239



>NP_001028723
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EGVAVASP 8
           EG+ VA P
Sbjct: 375 EGIPVAQP 382



>NP_001136336
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG+ VA+P
Sbjct: 761 EGLGVATP 768



>XP_006723212
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   EGVAVASPR 9
           EG  ++SP+
Sbjct: 271 EGTVISSPK 279



>XP_006721417
          Length = 2497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG+ VA+P
Sbjct: 761 EGLGVATP 768



>XP_006721416
          Length = 2504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG+ VA+P
Sbjct: 744 EGLGVATP 751



>XP_005254315
          Length = 2576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>XP_005254314
          Length = 2605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>XP_006720509
          Length = 2646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>XP_005254313
          Length = 3057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>XP_005254312
          Length = 3058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG++V SP
Sbjct: 582 EGMSVGSP 589



>NP_954586
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EGVAVASP 8
           EG A+A+P
Sbjct: 286 EGAALATP 293



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.124    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 629,757
Number of extensions: 1480
Number of successful extensions: 55
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)