Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     390
NP_001277143                                                           20     390
NP_001077383                                                           20     390
NP_001320                                                              20     390
NP_073713                                                              20     390
XP_005269629                                                           20     390
XP_005269628                                                           20     390
XP_005269627                                                           20     390
XP_005269626                                                           20     390
XP_006717706                                                           20     390
XP_005269625                                                           20     390
XP_005269624                                                           20     390
XP_006717705                                                           20     390
XP_005269622                                                           20     390
XP_005269621                                                           20     390
XP_006717704                                                           20     390
XP_005269619                                                           20     390
XP_005269618                                                           20     390
NP_001319                                                              17    3301
NP_001012632                                                           17    3301
XP_005272320                                                           17    3301
XP_005272319                                                           17    3301
XP_005272318                                                           17    3301
NP_001182657                                                           16    5631
NP_004162                                                              16    5631
NP_001239581                                                           16    5631
NP_065803                                                              16    5631
NP_057149                                                              16    5631
NP_001129516                                                           16    5631
XP_005253124                                                           16    5631
XP_006718340                                                           16    5631
XP_005253123                                                           16    5631
XP_005250428                                                           16    5631
NP_113622                                                              16    5631
NP_997320                                                              16    7355
NP_932068                                                              16    7355
NP_001073341                                                           16    7355
NP_003579                                                              16    7355
XP_006725230                                                           16    7355
XP_006724848                                                           16    7355
XP_006724847                                                           16    7355
XP_005262538                                                           16    7355
XP_006720283                                                           16    7355
XP_005253612                                                           16    7355
XP_005273720                                                           16    7355
NP_065869                                                              16    7355
NP_085128                                                              15    9605
NP_060855                                                              15    9605
NP_001264198                                                           15    9605
NP_057693                                                              15    9605
NP_055501                                                              15    9605
NP_002694                                                              15    9605
NP_001258540                                                           15    9605
NP_001258539                                                           15    9605
NP_003756                                                              15    9605
NP_065105                                                              15    9605
NP_001258538                                                           15    9605
XP_005259501                                                           15    9605
XP_005267805                                                           15    9605
XP_005267804                                                           15    9605
XP_005271472                                                           15    9605
XP_005271471                                                           15    9605
XP_005271470                                                           15    9605
XP_005271469                                                           15    9605
NP_003384                                                              15    9605
NP_689800                                                              15    9605
NP_001009894                                                           15    9605
NP_006773                                                              15    9605
>NP_001277144
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>NP_001277143
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>NP_001077383
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>NP_001320
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 721 ETLGLIGF 728
>XP_005269629
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269628
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269627
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269626
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_006717706
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269625
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269624
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_006717705
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269622
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269621
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_006717704
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269619
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>XP_005269618
          Length = 445

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ETLGLIGF 9
           ETLGLIGF
Sbjct: 181 ETLGLIGF 188
>NP_001319
          Length = 440

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           ETLG+IG
Sbjct: 175 ETLGIIG 181
>NP_001012632
          Length = 429

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           ETLG+IG
Sbjct: 164 ETLGIIG 170
>XP_005272320
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           ETLG+IG
Sbjct: 164 ETLGIIG 170
>XP_005272319
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           ETLG+IG
Sbjct: 164 ETLGIIG 170
>XP_005272318
          Length = 441

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           ETLG+IG
Sbjct: 175 ETLGIIG 181
>NP_001182657
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 234 LGLIGF 239
>NP_004162
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 243 LGLIGF 248
>NP_001239581
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 234 LGLIGF 239
>NP_065803
          Length = 1215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EETLGLIG 8
           E+TLGL G
Sbjct: 911 EKTLGLAG 918
>NP_057149
          Length = 137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EETLGLIGF 9
          E+ LGL GF
Sbjct: 88 EKLLGLAGF 96
>NP_001129516
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TLGLIGF 9
           TLGL GF
Sbjct: 226 TLGLAGF 232
>XP_005253124
          Length = 571

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 240 LGLIGF 245
>XP_006718340
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 248 LGLIGF 253
>XP_005253123
          Length = 590

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGLIGF
Sbjct: 259 LGLIGF 264
>XP_005250428
          Length = 126

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EETLGLIG 8
          E+T GL+G
Sbjct: 16 EQTTGLVG 23
>NP_113622
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TLGLIGF 9
           TLGL GF
Sbjct: 226 TLGLAGF 232
>NP_997320
          Length = 4471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EETLGLIG 8
            E+TL LIG
Sbjct: 1464 EKTLSLIG 1471
>NP_932068
          Length = 113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EETLGLIG 8
          EE+ GL+G
Sbjct: 92 EESAGLVG 99
>NP_001073341
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EETLGLIGF 9
           E+TL  +GF
Sbjct: 104 EDTLEFVGF 112
>NP_003579
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EETLGLIGF 9
           E+TL  +GF
Sbjct: 122 EDTLEFVGF 130
>XP_006725230
          Length = 2636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EETLGL 6
            EETLGL
Sbjct: 2021 EETLGL 2026
>XP_006724848
          Length = 900

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EETLGLIGF 9
           E+TL  +GF
Sbjct: 109 EDTLEFVGF 117
>XP_006724847
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EETLGLIGF 9
           E+TL  +GF
Sbjct: 109 EDTLEFVGF 117
>XP_005262538
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EETLGLIGF 9
           E+TL  +GF
Sbjct: 122 EDTLEFVGF 130
>XP_006720283
          Length = 2636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EETLGL 6
            EETLGL
Sbjct: 2021 EETLGL 2026
>XP_005253612
          Length = 4589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    EETLGLIG 8
            E+TL LIG
Sbjct: 1582 EKTLSLIG 1589
>XP_005273720
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LGLIGF 9
          LGL+GF
Sbjct: 91 LGLVGF 96
>NP_065869
          Length = 2458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EETLGL 6
            EETLGL
Sbjct: 1843 EETLGL 1848
>NP_085128
          Length = 2136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EETLGLIG 8
           +ETLG+ G
Sbjct: 416 QETLGMSG 423
>NP_060855
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TLGLIGF 9
           T+GL+G+
Sbjct: 388 TVGLVGY 394
>NP_001264198
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EETLGLIG 8
           E+T+GL G
Sbjct: 646 EDTVGLCG 653
>NP_057693
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TLGLIG 8
           TLGL+G
Sbjct: 134 TLGLVG 139
>NP_055501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EETLGLI 7
           E+TLGL+
Sbjct: 473 EKTLGLV 479
>NP_002694
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TLGLIG 8
          TLGL+G
Sbjct: 34 TLGLVG 39
>NP_001258540
          Length = 200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EETLGLI 7
          EET+G++
Sbjct: 65 EETIGIV 71
>NP_001258539
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EETLGLI 7
          EET+G++
Sbjct: 65 EETIGIV 71
>NP_003756
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EETLGLI 7
          EET+G++
Sbjct: 65 EETIGIV 71
>NP_065105
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TLGLIG 8
           TLGL+G
Sbjct: 134 TLGLVG 139
>NP_001258538
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  EETLGLI 7
          EET+G++
Sbjct: 65 EETIGIV 71
>XP_005259501
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EETLGLI 7
           E+TLGL+
Sbjct: 473 EKTLGLV 479
>XP_005267805
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TLGLIG 8
           TLGL+G
Sbjct: 134 TLGLVG 139
>XP_005267804
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TLGLIG 8
           TLGL+G
Sbjct: 134 TLGLVG 139
>XP_005271472
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLGLI 7
           ETLGLI
Sbjct: 201 ETLGLI 206
>XP_005271471
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLGLI 7
           ETLGLI
Sbjct: 201 ETLGLI 206
>XP_005271470
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLGLI 7
           ETLGLI
Sbjct: 170 ETLGLI 175
>XP_005271469
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLGLI 7
           ETLGLI
Sbjct: 183 ETLGLI 188
>NP_003384
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ETLGLIG 8
           +TLGL+G
Sbjct: 260 KTLGLLG 266
>NP_689800
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ETLGLI 7
           ETLGLI
Sbjct: 201 ETLGLI 206
>NP_001009894
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EETLGLIG 8
           E+TL LIG
Sbjct: 191 EQTLELIG 198
>NP_006773
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LGLIGF 9
           LGL+GF
Sbjct: 271 LGLLGF 276
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.154    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 525,621
Number of extensions: 1080
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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