Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     299
NP_001087241                                                           20     299
XP_005265799                                                           20     299
XP_005265798                                                           20     299
XP_005265797                                                           20     299
NP_055478                                                              18    1135
XP_005271413                                                           18    1135
XP_005271412                                                           18    1135
XP_005271411                                                           18    1135
NP_054722                                                              17    3301
XP_005256326                                                           17    3301
NP_079408                                                              17    4312
NP_055619                                                              17    4312
XP_005256942                                                           17    4312
XP_005256941                                                           17    4312
XP_006721675                                                           17    4312
XP_006721673                                                           17    4312
XP_006721672                                                           17    4312
XP_005256939                                                           17    4312
XP_005256938                                                           17    4312
XP_006714089                                                           17    4312
XP_006714088                                                           17    4312
XP_005262715                                                           17    4312
NP_001138390                                                           16    7355
NP_001138386                                                           16    7355
NP_001138387                                                           16    7355
NP_000132                                                              16    7355
NP_075259                                                              16    7355
NP_001138388                                                           16    7355
NP_001138391                                                           16    7355
NP_001138385                                                           16    7355
NP_075418                                                              16    7355
NP_000923                                                              16    7355
NP_001012745                                                           16    7355
NP_006403                                                              16    7355
NP_789792                                                              16    7355
NP_001020279                                                           16    7355
NP_002276                                                              16    7355
NP_060371                                                              16    7355
XP_006719528                                                           16    7355
XP_005253963                                                           16    7355
XP_005253962                                                           16    7355
XP_005274109                                                           16    7355
XP_006718281                                                           16    7355
XP_006717776                                                           16    7355
XP_006717775                                                           16    7355
XP_006717774                                                           16    7355
XP_006717773                                                           16    7355
XP_006717772                                                           16    7355
XP_006717771                                                           16    7355
XP_005264002                                                           16    7355
XP_005264000                                                           16    7355
XP_006712586                                                           16    7355
XP_005263999                                                           16    7355
NP_001171812                                                           16    7355
NP_001137291                                                           16    7355
NP_000775                                                              15    9605
NP_938205                                                              15    9605
NP_001633                                                              15    9605
NP_055817                                                              15    9605
NP_296373                                                              15    9605
NP_001230228                                                           15    9605
NP_061743                                                              15    9605
NP_114476                                                              15    9605
NP_037413                                                              15    9605
XP_005260739                                                           15    9605
XP_005273758                                                           15    9605
XP_006718820                                                           15    9605
NP_005458                                                              15    9605
NP_001135748                                                           15    9605
NP_001135749                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EDYAEAALY 9
           ED+AEAALY
Sbjct: 695 EDHAEAALY 703
>NP_001087241
          Length = 972

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EDYAEAALY 9
           ED+AEAALY
Sbjct: 691 EDHAEAALY 699
>XP_005265799
          Length = 973

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EDYAEAALY 9
           ED+AEAALY
Sbjct: 692 EDHAEAALY 700
>XP_005265798
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EDYAEAALY 9
           ED+AEAALY
Sbjct: 696 EDHAEAALY 704
>XP_005265797
          Length = 977

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EDYAEAALY 9
           ED+AEAALY
Sbjct: 696 EDHAEAALY 704
>NP_055478
          Length = 1064

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    EDYAEAALY 9
            EDY E ALY
Sbjct: 1051 EDYIEPALY 1059
>XP_005271413
          Length = 973

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EDYAEAALY 9
           EDY E ALY
Sbjct: 960 EDYIEPALY 968
>XP_005271412
          Length = 1064

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    EDYAEAALY 9
            EDY E ALY
Sbjct: 1051 EDYIEPALY 1059
>XP_005271411
          Length = 1064

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    EDYAEAALY 9
            EDY E ALY
Sbjct: 1051 EDYIEPALY 1059
>NP_054722
          Length = 1227

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           EDY EAA+
Sbjct: 721 EDYVEAAV 728
>XP_005256326
          Length = 1192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           EDY EAA+
Sbjct: 686 EDYVEAAV 693
>NP_079408
          Length = 1342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    EDYAEAALY 9
            EDY   ALY
Sbjct: 1008 EDYQSIALY 1016
>NP_055619
          Length = 967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 951 EDYAEA 956
>XP_005256942
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 652 EDYAEA 657
>XP_005256941
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 652 EDYAEA 657
>XP_006721675
          Length = 668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 652 EDYAEA 657
>XP_006721673
          Length = 967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 951 EDYAEA 956
>XP_006721672
          Length = 967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 951 EDYAEA 956
>XP_005256939
          Length = 967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 951 EDYAEA 956
>XP_005256938
          Length = 967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           EDYAEA
Sbjct: 951 EDYAEA 956
>XP_006714089
          Length = 1281

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    EDYAEAALY 9
            EDY   ALY
Sbjct: 1008 EDYQSIALY 1016
>XP_006714088
          Length = 1283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDYAEAALY 9
           EDY   ALY
Sbjct: 949 EDYQSIALY 957
>XP_005262715
          Length = 1320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDYAEAALY 9
           EDY   ALY
Sbjct: 986 EDYQSIALY 994
>NP_001138390
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 259 DYLEIAIY 266
>NP_001138386
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 262 DYLEIAIY 269
>NP_001138387
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 285 DYLEIAIY 292
>NP_000132
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 374 DYLEIAIY 381
>NP_075259
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 375 DYLEIAIY 382
>NP_001138388
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 259 DYLEIAIY 266
>NP_001138391
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 286 DYLEIAIY 293
>NP_001138385
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 375 DYLEIAIY 382
>NP_075418
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 285 DYLEIAIY 292
>NP_000923
          Length = 1234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           +DYAEA +
Sbjct: 853 QDYAEALI 860
>NP_001012745
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EDYAEAALY 9
          E YA+ ALY
Sbjct: 25 EFYAKVALY 33
>NP_006403
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EDYAEAALY 9
          E YA+ ALY
Sbjct: 25 EFYAKVALY 33
>NP_789792
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DYAEAALY 9
           D+AE +LY
Sbjct: 199 DWAEGSLY 206
>NP_001020279
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DYAEAAL 8
            +YAEAAL
Sbjct: 1028 NYAEAAL 1034
>NP_002276
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DYAEAAL 8
            +YAEAAL
Sbjct: 1003 NYAEAAL 1009
>NP_060371
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DYAEAALY 9
          +Y EAA+Y
Sbjct: 70 NYQEAAIY 77
>XP_006719528
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DYAEAALY 9
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>XP_005253963
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 DYAEAALY 9
         +Y EAA+Y
Sbjct: 2 NYQEAAIY 9
>XP_005253962
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DYAEAALY 9
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>XP_005274109
          Length = 1234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           +DYAEA +
Sbjct: 853 QDYAEALI 860
>XP_006718281
          Length = 983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DYAEAALY 9
          D+AE +LY
Sbjct: 89 DWAEGSLY 96
>XP_006717776
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 393 DYLEIAIY 400
>XP_006717775
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 279 DYLEIAIY 286
>XP_006717774
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 305 DYLEIAIY 312
>XP_006717773
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 394 DYLEIAIY 401
>XP_006717772
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 393 DYLEIAIY 400
>XP_006717771
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DYAEAALY 9
           DY E A+Y
Sbjct: 394 DYLEIAIY 401
>XP_005264002
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DYAEAAL 8
           +YAEAAL
Sbjct: 672 NYAEAAL 678
>XP_005264000
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DYAEAAL 8
            +YAEAAL
Sbjct: 1003 NYAEAAL 1009
>XP_006712586
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DYAEAAL 8
            +YAEAAL
Sbjct: 1055 NYAEAAL 1061
>XP_005263999
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    DYAEAAL 8
            +YAEAAL
Sbjct: 1055 NYAEAAL 1061
>NP_001171812
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           +DYAEA +
Sbjct: 786 QDYAEALI 793
>NP_001137291
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DYAEAALY 9
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>NP_000775
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEAALY 9
           AEAALY
Sbjct: 169 AEAALY 174
>NP_938205
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 573 DDYAEA 578
>NP_001633
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           ED+ EAA+
Sbjct: 247 EDFTEAAV 254
>NP_055817
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EDYAEAALY 9
           E Y E A+Y
Sbjct: 193 ESYLEGAVY 201
>NP_296373
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   EDYAEAALY 9
           E Y E A+Y
Sbjct: 193 ESYLEGAVY 201
>NP_001230228
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           ED+ EAA+
Sbjct: 257 EDFTEAAV 264
>NP_061743
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   DYAEAALY 9
           DY E A Y
Sbjct: 308 DYEETAFY 315
>NP_114476
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   DYAEAALY 9
           DY E A Y
Sbjct: 308 DYEETAFY 315
>NP_037413
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 573 DDYAEA 578
>XP_005260739
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 573 DDYAEA 578
>XP_005273758
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 534 QDYAEA 539
>XP_006718820
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 555 QDYAEA 560
>NP_005458
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   EDYAEA 6
           +DYAEA
Sbjct: 588 QDYAEA 593
>NP_001135748
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           ED+ EAA+
Sbjct: 247 EDFTEAAV 254
>NP_001135749
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDYAEAAL 8
           ED+ EAA+
Sbjct: 247 EDFTEAAV 254
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.125    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 451,477
Number of extensions: 524
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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