Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_110390                                                              18    1935
XP_006724753                                                           18    1935
XP_006724752                                                           18    1935
XP_006724751                                                           18    1935
NP_001182036                                                           17    2528
NP_112218                                                              17    2528
NP_001182035                                                           17    2528
NP_001017388                                                           17    2528
NP_001182037                                                           17    2528
XP_006714095                                                           17    2528
XP_006714094                                                           17    2528
XP_006711547                                                           17    3301
NP_000085                                                              17    4312
NP_060009                                                              17    4312
XP_003960325                                                           17    4312
XP_006721125                                                           17    4312
XP_003119208                                                           17    4312
XP_003119825                                                           17    4312
NP_060626                                                              16    5631
NP_056193                                                              16    5631
NP_001460                                                              16    5631
NP_001275906                                                           16    5631
NP_001275905                                                           16    5631
NP_001275907                                                           16    5631
NP_940880                                                              16    5631
NP_001164120                                                           16    7355
NP_001164121                                                           16    7355
NP_112483                                                              16    7355
NP_001177875                                                           16    7355
XP_005262364                                                           16    7355
XP_005262358                                                           16    7355
XP_006714949                                                           16    7355
XP_006714945                                                           16    7355
XP_006714943                                                           16    7355
XP_006714942                                                           16    7355
XP_006714941                                                           16    7355
XP_006714940                                                           16    7355
XP_006714939                                                           16    7355
XP_006714938                                                           16    7355
NP_001001391                                                           15    9605
NP_001001389                                                           15    9605
NP_001001390                                                           15    9605
NP_000601                                                              15    9605
NP_001189484                                                           15    9605
NP_001189485                                                           15    9605
NP_941374                                                              15    9605
NP_065682                                                              15    9605
NP_001036128                                                           15    9605
NP_001036130                                                           15    9605
NP_001036129                                                           15    9605
NP_001252522                                                           15    9605
NP_001252521                                                           15    9605
NP_001252523                                                           15    9605
NP_004565                                                              15    9605
NP_031382                                                              15    9605
NP_079203                                                              15    9605
XP_006722160                                                           15    9605
XP_006722159                                                           15    9605
XP_005253297                                                           15    9605
XP_005253296                                                           15    9605
XP_005253295                                                           15    9605
XP_005253292                                                           15    9605
XP_005253291                                                           15    9605
XP_005253290                                                           15    9605
XP_006718452                                                           15    9605
XP_006718451                                                           15    9605
XP_005253289                                                           15    9605
XP_005253288                                                           15    9605
XP_005250289                                                           15    9605
>NP_110390
          Length = 282

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDRRETG 7
           EDR+ETG
Sbjct: 200 EDRKETG 206
>XP_006724753
          Length = 272

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDRRETG 7
           EDR+ETG
Sbjct: 190 EDRKETG 196
>XP_006724752
          Length = 273

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDRRETG 7
           EDR+ETG
Sbjct: 191 EDRKETG 197
>XP_006724751
          Length = 283

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDRRETG 7
           EDR+ETG
Sbjct: 201 EDRKETG 207
>NP_001182036
          Length = 811

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 759 KDRRKCGLF 767
>NP_112218
          Length = 811

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 759 KDRRKCGLF 767
>NP_001182035
          Length = 811

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 759 KDRRKCGLF 767
>NP_001017388
          Length = 811

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 759 KDRRKCGLF 767
>NP_001182037
          Length = 797

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 745 KDRRKCGLF 753
>XP_006714095
          Length = 797

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 745 KDRRKCGLF 753
>XP_006714094
          Length = 797

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EDRRETGLF 9
           +DRR+ GLF
Sbjct: 745 KDRRKCGLF 753
>XP_006711547
          Length = 572

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EDRRETGL 8
          +DRR TGL
Sbjct: 31 QDRRATGL 38
>NP_000085
          Length = 2944

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           E RRETGL
Sbjct: 447 EWRRETGL 454
>NP_060009
          Length = 4116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DRRETGLF 9
            DRR  GLF
Sbjct: 2121 DRRRKGLF 2128
>XP_003960325
          Length = 207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR ETG+
Sbjct: 107 EDRPETGV 114
>XP_006721125
          Length = 4070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DRRETGLF 9
            DRR  GLF
Sbjct: 2075 DRRRKGLF 2082
>XP_003119208
          Length = 207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR ETG+
Sbjct: 107 EDRPETGV 114
>XP_003119825
          Length = 207

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR ETG+
Sbjct: 107 EDRPETGV 114
>NP_060626
          Length = 4363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRRETGLF 9
            +R+E GLF
Sbjct: 1587 ERKENGLF 1594
>NP_056193
          Length = 4388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRRETGLF 9
            +R+E GLF
Sbjct: 1587 ERKENGLF 1594
>NP_001460
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRRETGLF 9
           D R+TG+F
Sbjct: 192 DLRDTGIF 199
>NP_001275906
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRRETGLF 9
           D R+TG+F
Sbjct: 151 DLRDTGIF 158
>NP_001275905
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRRETGLF 9
           D R+TG+F
Sbjct: 192 DLRDTGIF 199
>NP_001275907
          Length = 559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRRETGLF 9
           D R+TG+F
Sbjct: 142 DLRDTGIF 149
>NP_940880
          Length = 832

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EDRRETG 7
           EDR++TG
Sbjct: 675 EDRQQTG 681
>NP_001164120
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDRRETGLF 9
           EDR E G F
Sbjct: 586 EDRMEVGPF 594
>NP_001164121
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDRRETGLF 9
           EDR E G F
Sbjct: 544 EDRMEVGPF 552
>NP_112483
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDRRETGLF 9
           EDR E G F
Sbjct: 603 EDRMEVGPF 611
>NP_001177875
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDRRETG 7
           ED R+TG
Sbjct: 139 EDERQTG 145
>XP_005262364
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDRRETGLF 9
           EDR E G F
Sbjct: 301 EDRMEVGPF 309
>XP_005262358
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EDRRETGLF 9
           EDR E G F
Sbjct: 603 EDRMEVGPF 611
>XP_006714949
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDRRETG 7
           ED R+TG
Sbjct: 139 EDERQTG 145
>XP_006714945
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDRRETG 7
           ED R+TG
Sbjct: 139 EDERQTG 145
>XP_006714943
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EDRRETG 7
          ED R+TG
Sbjct: 26 EDERQTG 32
>XP_006714942
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EDRRETG 7
          ED R+TG
Sbjct: 26 EDERQTG 32
>XP_006714941
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EDRRETG 7
          ED R+TG
Sbjct: 26 EDERQTG 32
>XP_006714940
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EDRRETG 7
          ED R+TG
Sbjct: 26 EDERQTG 32
>XP_006714939
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  EDRRETG 7
          ED R+TG
Sbjct: 26 EDERQTG 32
>XP_006714938
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   EDRRETG 7
           ED R+TG
Sbjct: 139 EDERQTG 145
>NP_001001391
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 311 EDRKPSGL 318
>NP_001001389
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 649 EDRKPSGL 656
>NP_001001390
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 443 EDRKPSGL 450
>NP_000601
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 692 EDRKPSGL 699
>NP_001189484
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 379 EDRKPSGL 386
>NP_001189485
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 290 EDRKPSGL 297
>NP_941374
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRRETGL 8
           DR+ TGL
Sbjct: 128 DRKSTGL 134
>NP_065682
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DRRETGL 8
          DR+ TGL
Sbjct: 51 DRKSTGL 57
>NP_001036128
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRRETGL 8
           DR+ TGL
Sbjct: 107 DRKSTGL 113
>NP_001036130
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DRRETGL 8
          DR+ TGL
Sbjct: 51 DRKSTGL 57
>NP_001036129
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DRRETGL 8
          DR+ TGL
Sbjct: 51 DRKSTGL 57
>NP_001252522
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRRETGL 8
           DR+ TGL
Sbjct: 120 DRKSTGL 126
>NP_001252521
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRRETGL 8
           DR+ TGL
Sbjct: 130 DRKSTGL 136
>NP_001252523
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DRRETGL 8
          DR+ TGL
Sbjct: 51 DRKSTGL 57
>NP_004565
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  EDRRETGL 8
          EDR E G+
Sbjct: 14 EDRTEAGI 21
>NP_031382
          Length = 1761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDRRET 6
            ED+RET
Sbjct: 1204 EDKRET 1209
>NP_079203
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRETGLF 9
           R+ETGL+
Sbjct: 160 RKETGLW 166
>XP_006722160
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRETGLF 9
           R+ETGL+
Sbjct: 160 RKETGLW 166
>XP_006722159
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRETGLF 9
           R+ETGL+
Sbjct: 160 RKETGLW 166
>XP_005253297
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 485 EDRKPSGL 492
>XP_005253296
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 528 EDRKPSGL 535
>XP_005253295
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 530 EDRKPSGL 537
>XP_005253292
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 650 EDRKPSGL 657
>XP_005253291
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 652 EDRKPSGL 659
>XP_005253290
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 653 EDRKPSGL 660
>XP_006718452
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 685 EDRKPSGL 692
>XP_006718451
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 691 EDRKPSGL 698
>XP_005253289
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 692 EDRKPSGL 699
>XP_005253288
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EDRRETGL 8
           EDR+ +GL
Sbjct: 693 EDRKPSGL 700
>XP_005250289
          Length = 1761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    EDRRET 6
            ED+RET
Sbjct: 1204 EDKRET 1209
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.145    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 590,322
Number of extensions: 921
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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