Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              18    1935
NP_005913                                                              18    1935
XP_005267046                                                           18    1935
XP_005267045                                                           18    1935
NP_036553                                                              16    5631
NP_065928                                                              16    5631
XP_006722539                                                           16    5631
XP_005256527                                                           16    5631
NP_001129652                                                           16    5631
NP_055084                                                              16    7355
NP_001265055                                                           16    7355
NP_001265056                                                           16    7355
NP_001124177                                                           16    7355
NP_001124175                                                           16    7355
NP_001124176                                                           16    7355
NP_055730                                                              16    7355
NP_001242982                                                           16    7355
NP_001265054                                                           16    7355
NP_064450                                                              16    7355
NP_060009                                                              16    7355
XP_006721125                                                           16    7355
XP_006717494                                                           16    7355
XP_006717493                                                           16    7355
XP_006717492                                                           16    7355
XP_006717491                                                           16    7355
XP_006717490                                                           16    7355
XP_006717489                                                           16    7355
XP_006717488                                                           16    7355
XP_006717487                                                           16    7355
XP_006717486                                                           16    7355
XP_005262762                                                           16    7355
XP_005262761                                                           16    7355
XP_005273257                                                           16    7355
XP_006710739                                                           16    7355
XP_005270979                                                           16    7355
NP_056972                                                              16    7355
NP_001265524                                                           15    9605
NP_877577                                                              15    9605
NP_005907                                                              15    9605
NP_056265                                                              15    9605
NP_001036059                                                           15    9605
NP_115666                                                              15    9605
NP_005344                                                              15    9605
NP_001157888                                                           15    9605
XP_006724703                                                           15    9605
XP_005250405                                                           15    9605
XP_006715980                                                           15    9605
XP_005272170                                                           15    9605
NP_005889                                                              15    9605
NP_976240                                                              15    9605
>NP_006715
          Length = 1558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            E IQKSVRL
Sbjct: 1245 EAIQKSVRL 1253
>NP_005913
          Length = 1608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            E IQKSVRL
Sbjct: 1295 EAIQKSVRL 1303
>XP_005267046
          Length = 1554

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            E IQKSVRL
Sbjct: 1241 EAIQKSVRL 1249
>XP_005267045
          Length = 1604

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            E IQKSVRL
Sbjct: 1291 EAIQKSVRL 1299
>NP_036553
          Length = 1914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DIQKSVRL 9
           DI+KSV+L
Sbjct: 833 DIKKSVKL 840
>NP_065928
          Length = 4427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EDIQKSV 7
            EDIQKS+
Sbjct: 1514 EDIQKSL 1520
>XP_006722539
          Length = 75

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EDIQKSVR 8
          ED+QK+V+
Sbjct: 48 EDLQKNVK 55
>XP_005256527
          Length = 4427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EDIQKSV 7
            EDIQKS+
Sbjct: 1514 EDIQKSL 1520
>NP_001129652
          Length = 74

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  EDIQKSVR 8
          ED+QK+V+
Sbjct: 48 EDLQKNVK 55
>NP_055084
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_001265055
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_001265056
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_001124177
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_001124175
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_001124176
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_055730
          Length = 1710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QK+++
Sbjct: 954 EDLQKTIK 961
>NP_001242982
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QK+++
Sbjct: 953 EDLQKTIK 960
>NP_001265054
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>NP_064450
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DIQKSVRL 9
           DIQ+++RL
Sbjct: 198 DIQQAIRL 205
>NP_060009
          Length = 4116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            +D++K +RL
Sbjct: 2294 QDVEKCIRL 2302
>XP_006721125
          Length = 4070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    EDIQKSVRL 9
            +D++K +RL
Sbjct: 2248 QDVEKCIRL 2256
>XP_006717494
          Length = 1571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QK+++
Sbjct: 815 EDLQKTIK 822
>XP_006717493
          Length = 1610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QK+++
Sbjct: 854 EDLQKTIK 861
>XP_006717492
          Length = 1635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1316 EDLQKTIK 1323
>XP_006717491
          Length = 1677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QK+++
Sbjct: 921 EDLQKTIK 928
>XP_006717490
          Length = 1791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1035 EDLQKTIK 1042
>XP_006717489
          Length = 1945

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1316 EDLQKTIK 1323
>XP_006717488
          Length = 2031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1316 EDLQKTIK 1323
>XP_006717487
          Length = 2071

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1315 EDLQKTIK 1322
>XP_006717486
          Length = 2072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    EDIQKSVR 8
            ED+QK+++
Sbjct: 1316 EDLQKTIK 1323
>XP_005262762
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>XP_005262761
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           +D++KSV L
Sbjct: 260 DDVRKSVHL 268
>XP_005273257
          Length = 1726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DIQKSVRL 9
           DIQ+++RL
Sbjct: 198 DIQQAIRL 205
>XP_006710739
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QKS++
Sbjct: 525 EDLQKSLQ 532
>XP_005270979
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QKS++
Sbjct: 525 EDLQKSLQ 532
>NP_056972
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           ED+QKS++
Sbjct: 525 EDLQKSLQ 532
>NP_001265524
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           ED+ +++RL
Sbjct: 452 EDVNEAIRL 460
>NP_877577
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           ED+ +++RL
Sbjct: 452 EDVNEAIRL 460
>NP_005907
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           ED+ +++RL
Sbjct: 628 EDVNEAIRL 636
>NP_056265
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EDIQKSV 7
           +D+QKSV
Sbjct: 577 DDLQKSV 583
>NP_001036059
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EDIQKSV 7
           +D+QKSV
Sbjct: 446 DDLQKSV 452
>NP_115666
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDIQKSVRL 9
           EDIQ+S  L
Sbjct: 302 EDIQRSYTL 310
>NP_005344
          Length = 1161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   DIQKSVR 8
           DIQ SVR
Sbjct: 667 DIQSSVR 673
>NP_001157888
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DIQKSVRL 9
           DIQ +VRL
Sbjct: 116 DIQMAVRL 123
>XP_006724703
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DIQKSVRL 9
           DIQ +VRL
Sbjct: 116 DIQMAVRL 123
>XP_005250405
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EDIQKSVRL 9
           ED+ +++RL
Sbjct: 521 EDVNEAIRL 529
>XP_006715980
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EDIQKSV 7
           +D+QKSV
Sbjct: 577 DDLQKSV 583
>XP_005272170
          Length = 1058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDIQKSVRL 9
           EDIQ+S  L
Sbjct: 302 EDIQRSYTL 310
>NP_005889
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           +DIQK+++
Sbjct: 121 QDIQKTIK 128
>NP_976240
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   EDIQKSVR 8
           +DIQK+++
Sbjct: 121 QDIQKTIK 128
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.132    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 358,155
Number of extensions: 558
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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